Reliability of frozen section examination in identifying poor prognostic indicators in stage I endometrial adenocarcinoma.

abstract：OBJECTIVE:To evaluate c-erbB2 gene amplification in a series of primary uterine serous carcinoma (USC) cell lines. To assess the efficacy of AZD8055, a novel dual mTORC1/2 inhibitor against primary HER2/neu amplified vs HER2/neu not amplified USC cell lines. METHODS:Twenty-two primary USC cell lines were evaluated for...

journal_title：Gynecologic oncology

authors： English DP,Roque DM,Carrara L,Lopez S,Bellone S,Cocco E,Bortolomai I,Schwartz PE,Rutherford T,Santin AD

更新日期：2013-12-01 00:00:00

abstract：:Forty-three patients with ovarian cancer were entered on this trial and treated with intravenous (iv) cyclophosphamide (C) and doxorubicin (A), and intraperitoneal (ip) cisplatin (DDP), every 21 days for eight cycles. Following iv hydration, the cisplatin was administered through an intraperitoneal catheter in 2 L of ...

journal_title：Gynecologic oncology

authors： Morgan RJ Jr,Braly P,Cecchi G,Leong L,Shibata S,Margolin K,Somlo G,McNamara M,Longmate J,Schinke S,Raschko J,Nagasawa S,Kogut N,Parker P,Stein A,Cho J,Smith E,Coluzzi P,Najera L,Johnson D,Womack E,Doroshow JH

更新日期：1999-12-01 00:00:00

abstract：:An epidemiologic study of multiple primary malignant neoplasms in endometrial cancer patients in Israel is presented. During the 7-year period of the study, 104 patients (10.3%) out of 1007 patients diagnosed as having endometrial cancer had another primary cancer. There was a significant difference in the incidence o...

journal_title：Gynecologic oncology

authors： Schwartz Z,Ohel G,Birkenfeld A,Anteby SO,Schenker JG

更新日期：1985-09-01 00:00:00

abstract：:Sentinel node mapping is increasingly being utilized for endometrial cancer staging. However, only limited evidence supporting the adoption of sentinel node mapping instead of conventional lymphadenectomy is still available. Here, we aimed to review the current evidence comparing sentinel node mapping and lymphadenect...

journal_title：Gynecologic oncology

authors： Bogani G,Murgia F,Ditto A,Raspagliesi F

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Practitioners and researchers require an outcome measure that accurately identifies the range of common treatment-induced changes in sexual function and well-being experienced by women after cervical or endometrial cancer. This systematic review critically appraised the measurement properties and clinical ut...

journal_title：Gynecologic oncology

authors： White ID,Sangha A,Lucas G,Wiseman T

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Serous borderline ovarian tumors (SBOT) are slow growing, noninvasive ovarian epithelial neoplasms, which tend to recur as low-grade invasive carcinomas (LGC) with a much worse prognosis. We investigated the molecular basis of this progression. METHODS:We established cultures of three SBOTs and one LGC from ...

journal_title：Gynecologic oncology

authors： Woo MM,Salamanca CM,Symowicz J,Stack MS,Miller DM,Leung PC,Gilks CB,Auersperg N

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:For many years, BRCA mutational status has only been considered as a predictor of ovarian cancer susceptibility and as a prognostic factor. Nonetheless, in the era of precision medicine, it has also become a predictive biomarker of response to platinum-based-chemotherapy and, more recently, to PARP-inhibitors...

journal_title：Gynecologic oncology

authors： Marchetti C,Minucci A,D'Indinosante M,Ergasti R,Arcieri M,Capoluongo ED,Pietragalla A,Caricato C,Scambia G,Fagotti A

更新日期：2020-09-01 00:00:00

abstract：:The ovary is a relatively frequent site of metastasis from malignant neoplasia arising elsewhere in the body, the majority of these originating from the GI tract. The best known tumor of this type is signet-ring cell adenocarcinoma (Krukenberg tumor) of gastric origin. The gall bladder and bile ducts are rare sources ...

journal_title：Gynecologic oncology

authors： Lashgari M,Behmaram B,Hoffman JS,Garcia J

更新日期：1992-11-01 00:00:00

abstract：:Mullerian Inhibiting Substance (MIS), a fetal testicular product that causes regression of the Mullerian duct in the male mammalian embryo, was evaluated for its antitumor effect on the premise that a substance active against this genital precursor in the fetus might also be active against tumors derived from these ti...

journal_title：Gynecologic oncology

authors： Fuller AF Jr,Krane IM,Budzik GP,Donahoe PK

更新日期：1985-10-01 00:00:00

abstract：:One hundred and three patients treated with CAP chemotherapy were evaluated to determine the relationship between low prechemotherapy serum albumin (less than 3 g/dl) and low WBC nadir (less than 2000 cells/mm3). Additionally, the relationship of serum albumin to renal toxicity (delta serum creatinine) was examined. L...

journal_title：Gynecologic oncology

authors： Belinson JL,Jarrell MA,McClure M,Kulig PM,Badger GJ

更新日期：1990-04-01 00:00:00

abstract：:Sizes of the largest metastatic nodes were evaluated as a prognostic factor in 152 patients with Stage IB to IIB cervical carcinomas treated by radical hysterectomy and postoperative irradiation. Of the 152 cases, the largest positive nodes were less than 10 mm in 24 (16%), 10-20 mm in 74 (49%), greater than or equal ...

journal_title：Gynecologic oncology

authors： Inoue T,Chihara T,Morita K

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer. METHODS:We identified 118 patients with locally advanced cervical cancer (stages I...

journal_title：Gynecologic oncology

authors： Nugent EK,Case AS,Hoff JT,Zighelboim I,DeWitt LL,Trinkhaus K,Mutch DG,Thaker PH,Massad LS,Rader JS

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:We evaluated the use of positron emission tomography (PET) with fluorine-18-labeled fluoro-2-deoxy-d-glucose (FDG) in follow-up study after radiation therapy in patients with uterine cervical carcinoma. MATERIALS AND METHODS:Thirty-two studies in 25 patients were reviewed. Twenty patients were treated with ext...

journal_title：Gynecologic oncology

authors： Sakurai H,Suzuki Y,Nonaka T,Ishikawa H,Shioya M,Kiyohara H,Katoh H,Nakayama Y,Hasegawa M,Nakano T

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To determine if tumor-free distance (TFD) from the uterine serosa predicts surgicopathologic factors and outcome in surgically staged endometrial cancer, and to compare TFD with the traditional estimate of depth of myometrial invasion (DOI). METHODS:Patients who underwent complete surgical staging for primar...

journal_title：Gynecologic oncology

authors： Schwab KV,O'Malley DM,Fowler JM,Copeland LJ,Cohn DE

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study is to develop a risk-scoring system for predicting lymph node and distant metastasis in endometrial carcinoma. METHODS:A total of 1166 patients, treated at a single institution between 1-2007 and 12-2013, were included in the study. The association of stage IIIC-IV disease with demograp...

journal_title：Gynecologic oncology

authors： Tuomi T,Pasanen A,Luomaranta A,Leminen A,Bützow R,Loukovaara M

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Endometrial cancer (EC) is a rare condition in young women. The objective of this study was to evaluate the risk of pelvic lymph node (LN) metastasis in young women with EC who are candidates for conservative management. METHODS:Using the SEER database, a population-based analysis was conducted to identify w...

journal_title：Gynecologic oncology

authors： Gonthier C,Douhnai D,Koskas M

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS:...

journal_title：Gynecologic oncology

authors： Maxwell GL,Allard J,Gadisetti CV,Litzi T,Casablanca Y,Chandran U,Darcy KM,Levine DA,Berchuck A,Hamilton CA,Conrads TP,Risinger JI

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:We evaluated the clinical relevance of catenins, cadherins and cell cycle regulators in stage IV or recurrent endometrial carcinoma in a multi-center phase II trial (GOG protocol #119). METHODS:Tissue microarrays of metastatic or recurrent (n=42) tumor were developed and immunohistochemistry was performed. A...

journal_title：Gynecologic oncology

authors： Singh M,Darcy KM,Brady WE,Clubwala R,Weber Z,Rittenbach JV,Akalin A,Whitney CW,Zaino R,Ramirez NC,Leslie KK

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to establish a reference 24-hour urine human chorionic gonadotropin (hCG) regression curve in patients with complete hydatidiform mole (CHM) as diagnostic tool in the prediction of persistent trophoblastic disease (PTD). METHODS:From 2004 to 2011, 312 cases suitable for this study w...

journal_title：Gynecologic oncology

authors： van Cromvoirt SM,Thomas CM,Quinn MA,McNally OM,Bekkers RL

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To update the demographic data, treatment details and outcomes for GTN patients with brain metastases managed with the modern treatment protocols at the UK centre for gestational trophoblast neoplasia at Charing Cross Hospital in London. METHODS:The hospital database and pharmacy records were reviewed to ide...

journal_title：Gynecologic oncology

authors： Savage P,Kelpanides I,Tuthill M,Short D,Seckl MJ

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To determine the antitumor activity and toxicity profile of gemcitabine as second-line chemotherapy in patients with recurrent or persistent uterine leiomyosarcoma (LMS). METHODS:Intravenous gemcitabine was administered over 30 min at a dose of 1000 mg/m(2) on days 1, 8, 15, with cycles repeated every 28 day...

journal_title：Gynecologic oncology

authors： Look KY,Sandler A,Blessing JA,Lucci JA 3rd,Rose PG,Gynecologic Oncology Group (GOG) Study.

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:Many gynecologic oncology (GO) patients in Virginia are low income and their care is supplemented by Disproportionate Share Hospital (DSH) funds. Our objective is to estimate how many new GO patients may lose access to care if the state forgoes Medicaid expansion. METHODS:New patients referred to the GO serv...

journal_title：Gynecologic oncology

authors： Courtney-Brooks M,Pelkofski EB,Engelhard CL,Duska LR

更新日期：2013-08-01 00:00:00

abstract：:Fourteen patients with refractory or metastatic adenocarcinoma of the endometrium were treated with continuous infusion vinblastine. No patient had a response. One patient had stable disease. Although well tolerated, vinblastine sulfate given by this method has no activity in this malignancy. ...

journal_title：Gynecologic oncology

authors： Kavanagh JJ,Saul PB,Wharton JT,Rutledge FN

更新日期：1987-02-01 00:00:00

abstract：:In epithelial ovarian cancer, solitary metastasis to and recurrences in the parenchyma of the spleen are rare in the absence of apparent disease in other sites. We report four patients who developed isolated, solitary splenic parenchymal recurrences of their epithelial ovarian adenocarcinomas and underwent a splenecto...

journal_title：Gynecologic oncology

authors： Farias-Eisner R,Braly P,Berek JS

更新日期：1993-03-01 00:00:00

abstract：:Endocrine and clinicopathologic findings in a 77-year-old woman with ovarian mucinous adenofibroma of borderline malignancy are reported. The preoperative levels of testosterone, androstenedione, estrone, and estradiol in her peripheral blood were 91 ng/ml, 3.78 ng/ml, 82 pg/ml, and 35 pg/ml, respectively, abnormally ...

journal_title：Gynecologic oncology

authors： Tohya T,Mizutani H,Katabuchi H,Miyazaki K,Okamura H

更新日期：1994-08-01 00:00:00

abstract：:Endometrial adenocarcinoma in young women below the age of 45 years and in a functioning endometrium is rare. We present the case of a 41-year-old woman, who without clinical risk factors, was found to have a focal well-differentiated endometrial adenocarcinoma in the background of a histologically secretory endometri...

journal_title：Gynecologic oncology

authors： Pai UL,Razi A,Selim MA,Petrelli M

更新日期：1993-05-01 00:00:00

abstract：:The purpose of this study was to evaluate the differences of blood supply in benign and malignant breast tumors by color Doppler flow measurements. The study included 471 patients, 133 with carcinomas, 325 with benign breast lesions, and 13 with mastitis. An ATL UM9/HDI was used with an electronic 10-MHz linear array ...

journal_title：Gynecologic oncology

authors： Madjar H,Sauerbrei W,Prömpeler HJ,Wolfarth R,Gufler H

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Primary non-gestational choriocarcinoma of the female genital tract has been described in the ovaries and is very unusual in other genital sites. CASE:Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a patient, 32, single, without previous sexual contact nor antecedent pregnancy, ad...

journal_title：Gynecologic oncology

authors： Maestá I,Michelin OC,Traiman P,Hokama P,Rudge MV

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Ovarian carcinomas that originate from fallopian epithelial cells are suggested to arise due to repeated exposure to ovulatory follicular fluid (FF). Mechanistic explanation(s) for how this occurs are unknown. Here, we sought to understand if FF exposure to fallopian epithelial cells could induce DNA damage a...

journal_title：Gynecologic oncology

authors： Brachova P,Alvarez NS,Van Voorhis BJ,Christenson LK

更新日期：2017-06-01 00:00:00

abstract：:Angiogenesis is a proven clinical target for the treatment of advanced epithelial ovarian cancer. Vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) offer patients potential new treatment regimens as they can be given as monotherapy, in combination with poly(ADP-ribose) polymerase (PAR...

journal_title：Gynecologic oncology

authors： Liu J,Nicum S,Reichardt P,Croitoru K,Illek B,Schmidinger M,Rogers C,Whalen C,Jayson GC

更新日期：2018-07-01 00:00:00