Abstract：
:Spontaneous alternation was examined in young rats following microinjections of antinicotinic agents into one of the 4 hippocampal sites: anterodorsal, or posteroventral dentate gyrus, hippocampal gyrus, or entorhinal cortex. In control and saline-injected animals, the alternation rate was shown to grow suddenly from 40 to 80% between days 15 and 17 (the adult level being 85-90%), to regress partly (to 55%) between days 20 and 30, and return to a near-adult level (75%) by day 40. Meanwhile fear responses to environment (defecation and vocalization) emerged between days 20 and 25, increased to a maximum until day 30, and returned to the typically low adult level by day 40. Injections of mecamylamine (5, 20 micrograms) or hexamethonium (5, 20 micrograms) into any of the 4 sites significantly reduced the rate of alternation from as early as day 10 on, but were no longer effective from day 30 on; on the other hand, they did not alter the level of defecation, but had a tendency to lower the level of vocalization on day 30 only. These results indicate that hippocampal nicotinic cholinergic mechanisms play a role in spontaneous alternation and appear to be involved in the control of one fear reaction (vocalization) until day 30.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Blozovski D,Hess Cdoi
10.1016/s0166-4328(89)80142-1subject
Has Abstractpub_date
1989-12-01 00:00:00pages
209-20issue
3eissn
0166-4328issn
1872-7549pii
S0166-4328(89)80142-1journal_volume
35pub_type
杂志文章abstract：:Many studies of creative cognition with a neuroimaging component now exist; what do they say about where and how creativity arises in the brain? We reviewed 45 brain-imaging studies of creative cognition. We found little clear evidence of overlap in their results. Nearly as many different tests were used as there were...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/j.bbr.2010.05.015
更新日期：2010-12-25 00:00:00
abstract：:In this brief review, we present the evidence for the regulation of the mesolimbic dopamine system by 5-HT3 and 5-HT4 receptors. A range of studies show good evidence that 5-HT3 receptor antagonists reduce raised mesolimbic dopamine activity by blocking 5-HT3 receptors in terminal parts of the mesolimbic dopamine syst...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(96)00063-0
更新日期：1996-01-01 00:00:00
abstract：:Social isolation rearing (isolated condition, IC) is used as a model of early life stress in rodents. Rats raised in this condition are often compared to rats raised in an environmentally enriched condition (EC). However, EC rats are repeatedly exposed to forced novelty, another classic stressor in rodents. These stud...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2015.01.049
更新日期：2015-04-15 00:00:00
abstract：:The ventral pallidum (VP) is a critical element of the mesocorticolimbic system that is inter-connected with motor and limbic structures and may be considered as an interface between motivational and effector neural signals. Dopamine is important in behavioral output of the VP, and dysfunctioning its dopamine quantity...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.10.041
更新日期：2012-02-01 00:00:00
abstract：:To assess the role of endogenous peptides involved in stress responsivity in the development of diet-induced obesity (DIO), selectively bred DIO and diet-resistant (DR) male were weaned onto a low fat (4.5%) chow diet at 3 weeks of age and then fed either chow or a 31% fat by energy content (high energy (HE)) diet for...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2004.03.019
更新日期：2004-10-05 00:00:00
abstract：:Physical exercise could be a protective factor against the development of substance use disorders; however, a number of preclinical studies report reward-enhancing effects of exercise for various drugs of abuse. We examined the effects of chronic wheel-running on brain reward sensitivity, reaction to novelty, reward-f...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2020.112831
更新日期：2020-09-15 00:00:00
abstract：:The effects of upper lumbar level intrathecal injection of yohimbine, an alpha2-noradrenergic antagonist, on overground locomotion in intact rats was studied. This treatment caused dose-dependent impairment of hindlimb locomotor movement, which varied from transient hindlimb paralysis at a dose of 200 microg/20 microl...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.08.040
更新日期：2006-12-15 00:00:00
abstract：:Animal navigation to hidden goals (place navigation) ranks among the most intensively studied types of behaviour because it requires brain representations of environments in the form of cognitive maps, demonstrated to depend on hippocampal function. Intact function of muscarinic receptors in the brain was originally a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.02.012
更新日期：2005-06-20 00:00:00
abstract：:Diabetes mellitus, which causes hyperglycemia, affects the central nervous system and can impairs cognitive functions, such as memory. The aim of this study was to investigate the effects of hyperglycemia on memory as well as on the activity of acethylcholinesterase. Hyperglycemia was induced in adult zebrafish by imm...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.033
更新日期：2014-11-01 00:00:00
abstract：:The early detection of minor brain dysfunctions resulting from perinatal hypoxia is very important since the prognosis of the affected children can be substantially improved by a prompt treatment. Therefore, this paper deals with the influence of an early postnatal hypoxia on the postnatal development of spontaneous h...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(93)90148-j
更新日期：1993-12-31 00:00:00
abstract：:Neglect in human and non-human primates has been demonstrated following unilateral lesions of both posterior parietal and prefrontal areas. While it has now been well established that a unilateral lesion of the rodent analog of dorsolateral prefrontal cortex, medial agranular cortex (AGm), results in neglect, the effe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(93)90070-7
更新日期：1993-04-30 00:00:00
abstract：:Mildronate (3-(2,2,2-trimethylhydrazinium) propionate) is an inhibitor of l-carnitine biosynthesis and an anti-ischemic drug. In the present study, we investigated the effects of mildronate in rats following focal cerebral ischemia. Male Wistar rats were subjected to transient occlusion of the middle cerebral artery (...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.03.027
更新日期：2011-09-12 00:00:00
abstract：:Prenatal restraint stress (PS) has been suggested as an attractive chronic model of anxiety. Here, we characterized the behavioral and autonomic responsivity to acute stress exposure in adult PS subjects. In Wistar rats, locomotor activity, as well as spontaneous behavior in an established animal model of anxiety, the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00273-5
更新日期：2003-03-18 00:00:00
abstract：:In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(96)02261-9
更新日期：1997-07-01 00:00:00
abstract：:Experimental and clinical studies have generally shown that the neural mechanisms for face processing in man are (1) designed to deal with the configuration of upright faces and (2) located predominantly in the right cerebral hemisphere. Monkeys would seem to process faces in a different manner to humans since they ap...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90029-0
更新日期：1988-08-01 00:00:00
abstract：:These experiments examined the mnemonic functions of hippocampus and dorsal striatum in Pavlovian aversive conditioning. Rats were trained in a single session by presenting three paired tones and footshocks. Immediately after training, they were given microinjections of D-amphetamine or vehicle into either dorsal hipp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00402-3
更新日期：2003-06-16 00:00:00
abstract：:Synthetic cathinones share potent sympathomimetic properties with amphetamines due to their shared phenethylamine backbone. Despite recent work focused on understanding the behavioral effects of synthetic cathinones, a systematic comparison of neuropharmacology, behavior, and physiological effects with other stimulant...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2019.112368
更新日期：2020-02-03 00:00:00
abstract：:Voluntary wheel running in rodents is associated with a number of adaptive behavioral and physiological effects including improved learning, reduction in stress-associated behaviors, neurogenesis, angiogenesis, increases in neurotrophic factors, and changes in several signaling molecules. Exercise has also been report...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.07.036
更新日期：2009-01-30 00:00:00
abstract：:We developed a method to quantify the probability of a target neuron discharge following synchronous or asynchronous discharges among a pair of reference neurons. To illustrate this method, we simultaneously recorded three neurons having overlapping receptive fields in the somatosensory system: two reference neurons i...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00165-1
更新日期：2002-09-20 00:00:00
abstract：:The ability to cope successfully with stress is known as 'resilience', and those with resilience are not prone to developing depression. One preclinical animal model for depression is the chronic mild stress (CMS) model. There are CMS-resilient (do not manifest anhedonia) and CMS-susceptible (manifest anhedonia) rats....
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2018.11.017
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. METHODS:Memory performance was eval...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.02.003
更新日期：2013-05-15 00:00:00
abstract：:Studies of extinction in preweanling rats have failed to find ABA-renewal in a fear conditioning paradigm. This result supports the hypothesis postulating ontogenetic qualitative differences in experimental extinction. A similar result in adult rats led to the conclusion that ABA-renewal requires contexts A and B to d...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2013.07.027
更新日期：2013-09-15 00:00:00
abstract：:Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar ra...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.08.052
更新日期：2014-12-15 00:00:00
abstract：:The behavioural effects of hippocampal lesions have been extensively documented in rats. However, paradigms developed for rats cannot be assumed to transfer straightforwardly to mice; the behaviour of the two species differs in many respects. Mice are currently the species of choice for targeted genetic manipulations....
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00401-6
更新日期：2002-05-14 00:00:00
abstract：:The current study examined sex differences in initial and subsequent strategies in solving a navigational problem within a virtual reality environment. We tested 163 undergraduates on a virtual T-maze task that included probe trials designed to assess whether participants were responding using either a place or respon...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.04.037
更新日期：2016-07-15 00:00:00
abstract：:Development and characterization of animal models of depression are essential for fully understanding the pathogenesis of depression in humans. We made and analyzed a mouse model exhibiting social deficit and hyperphagia-like behavior using a subchronic and mild social defeat stress (sCSDS) paradigm. The body weight, ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.05.040
更新日期：2014-08-15 00:00:00
abstract：:Dysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low inte...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.01.053
更新日期：2017-05-15 00:00:00
abstract：:The effect of exogenous melatonin (MEL) on the circadian system in nocturnal species has been extensively studied, but little is known about its chronobiotic effect in diurnal mammals. The present study investigated the effect of exogenous MEL on the circadian locomotor activity rhythm in the diurnal rodent Arvicanthi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(01)00411-9
更新日期：2002-06-15 00:00:00
abstract：:Classical conditioning theories of addiction suggest that stimuli associated with rewards acquire incentive salience, inducing emotional and attentional conditioned responses. It is not clear whether those responses occur without contingency awareness (CA), i.e. are based on explicit or implicit learning processes. Ex...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.12.015
更新日期：2018-04-02 00:00:00
abstract：:The current study was performed to assess the effects of inorganic mercury (mercuric chloride - HgCl(2)) on the development of offsprings from intoxicated-mother during pregnancy. In this respect, pregnant rats were chronically treated with HgCl(2) at 50 ppm (Hg50) and 100 ppm (Hg100) in drinking water. After parturit...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2012.06.005
更新日期：2012-09-01 00:00:00
