Abstract：
:The effects of upper lumbar level intrathecal injection of yohimbine, an alpha2-noradrenergic antagonist, on overground locomotion in intact rats was studied. This treatment caused dose-dependent impairment of hindlimb locomotor movement, which varied from transient hindlimb paralysis at a dose of 200 microg/20 microl to transient trunk instability at 50 microg/20 microl. Repetitive (every 48 h) injections of yohimbine at high (200 microg/20 microl) and medium (100 microg/20 microl) doses caused tachyphylaxis, which usually led to a lack of reaction to the third injection. This phenomenon was not observed after repetitive injections of the low (50 microg/20 microl) dose of the drug. These results show that the noradrenergic system is involved in the control of locomotion, since intrathecal administration of a specific antagonist affects this activity in intact rats.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Majczyński H,Cabaj A,Sławińska U,Górska Tdoi
10.1016/j.bbr.2006.08.040subject
Has Abstractpub_date
2006-12-15 00:00:00pages
315-22issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(06)00496-7journal_volume
175pub_type
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