Abstract：
:Studies of extinction in preweanling rats have failed to find ABA-renewal in a fear conditioning paradigm. This result supports the hypothesis postulating ontogenetic qualitative differences in experimental extinction. A similar result in adult rats led to the conclusion that ABA-renewal requires contexts A and B to differ in several types of features, including odor cues. Recently we reported experimental evidence of the renewal of an extinguished taste aversion response in infant rats employing contexts which differ in their odor content. The present study examines the possibility of renewing an extinguished fear response in infant rats when contexts A and B do not include (Experiment 1) or include (Experiment 2) an explicit odor. Results showed absence of renewal when using standard contexts (without explicit odors, Experiment 1). However, when contexts A and B varied also in their odor content, the ABA-renewal procedure was effective in reinstating the extinguished CR (Experiment 2). Thus, it can be concluded that the sensory content of the context determines the observation of renewal in the infant rat, a result that is coherent with previous observations in the adult rat. As a whole, these results challenge our understanding of extinction as a learning process that is qualitatively different in preweanling rats than in later stages of ontogeny.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Revillo DA,Molina JC,Paglini MG,Arias Cdoi
10.1016/j.bbr.2013.07.027subject
Has Abstractpub_date
2013-09-15 00:00:00pages
173-7eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00426-9journal_volume
253pub_type
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