Abstract：
:Development and characterization of animal models of depression are essential for fully understanding the pathogenesis of depression in humans. We made and analyzed a mouse model exhibiting social deficit and hyperphagia-like behavior using a subchronic and mild social defeat stress (sCSDS) paradigm. The body weight, food and water intake of mice were monitored during a test period, and their behaviors and serum components were analyzed at two stages: immediately after the sCSDS period and 1 month after the sCSDS. The body weight and food intake of defeated mice were significantly higher than control mice at the sCSDS period, and these differences were sustained until 1 month after the sCSDS, whereas the water intake of defeated mice was significantly higher than control mice for the period of sCSDS only. Behavioral analyses revealed that the defeated mice exhibit significant social aversion to unfamiliar mice in a social interaction test and a trend of anxiety-like behavior in an elevated-plus maze test. Possibly due to polydipsia-like symptoms, defeated mice had significantly lower levels of albumin and blood urea nitrogen than control mice immediately after the sCSDS period but not at 1 month after sCSDS. The present study revealed that our sCSDS mice keep much more water in their body than control mice. This study reports the first step toward an understanding of the mechanisms of stress-induced overhydration, over-eating and resultant weight gain.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Goto T,Kubota Y,Tanaka Y,Iio W,Moriya N,Toyoda Adoi
10.1016/j.bbr.2014.05.040subject
Has Abstractpub_date
2014-08-15 00:00:00pages
339-48eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00343-Xjournal_volume
270pub_type
杂志文章abstract：:Maternal care is the newborns' first experience of social interaction, which affects their development and social competence throughout life. For the first time, we investigated the involvement of the endocannabinoid system (ECS) in mother-infant interaction in mice. We found that blocking the dam's CB1 receptors (CB1...
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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