Abstract：
:Maternal care is the newborns' first experience of social interaction, which affects their development and social competence throughout life. For the first time, we investigated the involvement of the endocannabinoid system (ECS) in mother-infant interaction in mice. We found that blocking the dam's CB1 receptors (CB1R) by the antagonist/inverse agonist rimonabant (SR141716) during postpartum days 1-8 affected maternal behavior as well as the social and emotional characteristics of the offspring as adults. Pups of rimonabant treated dams (RTD) had lower body weight during the first week of life and emitted fewer ultrasonic vocalizations (USVs) than vehicle treated dams (VTD). RTD crouched less over their pups and exhibited delayed pup retrieval. In Y-maze preference tests conducted at weaning age, females and males of both groups preferred their dam over milk. Males and females of RTD preferred dam over pup and pup over milk as opposed to the control group. At the age of 2.5 months, males of RTD displayed less motor activity. In the social behavior test, RTD male and female offspring were both more active, showing higher levels of active social interaction and rearing. These results indicate that the ECS is crucial for establishment of maternal behavior during the first postpartum week, with a long-term impact on the offspring's socio-emotional development.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Schechter M,Pinhasov A,Weller A,Fride Edoi
10.1016/j.bbr.2011.10.016subject
Has Abstractpub_date
2012-01-15 00:00:00pages
481-92issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(11)00734-0journal_volume
226pub_type
杂志文章abstract：:Action observation elicits changes in primary motor cortex known as motor resonance, a phenomenon thought to underpin several functions, including our ability to understand and imitate others' actions. Motor resonance is modulated not only by the observer's motor expertise, but also their gaze behaviour. The aim of th...
journal_title：Behavioural brain research
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abstract：:Rats with lesions in either the fornix or the thalamic nucleus medialis dorsalis were unimpaired on the acquisition of two object discrimination tasks. The same animals were then tested on a concurrent learning task in which various object discriminations were presented at different rates during the same session. This...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 临床试验,杂志文章
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更新日期：2002-07-18 00:00:00
abstract：:Synthetic cathinones share potent sympathomimetic properties with amphetamines due to their shared phenethylamine backbone. Despite recent work focused on understanding the behavioral effects of synthetic cathinones, a systematic comparison of neuropharmacology, behavior, and physiological effects with other stimulant...
journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.035
更新日期：2010-12-06 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-04-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-4328(93)90045-r
更新日期：1993-03-31 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(82)90004-3
更新日期：1982-03-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2006.04.004
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)83333-5
更新日期：1997-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(99)00038-8
更新日期：1999-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(95)00148-4
更新日期：1996-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-08-05 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1996-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-08-05 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1997-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2004-08-12 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
abstract：:Stressful life events and chronic stress are implicated in the development of depressive disorder in humans. Neuropeptide Y (NPY) and galanin have been shown to modulate the stress response, and exert antidepressant-like effects in rodents. To further investigate these neuropeptides in depression-like behaviour, NPY a...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.08.044
更新日期：2011-01-20 00:00:00
abstract：:Although both the presupplementary motor area (pre-SMA) and the right inferior frontal gyrus (rIFG) have been demonstrated to be critical for response inhibition, there is still considerable disagreement over the roles they play in the process. In the present study, we investigated the causal relations of the pre-SMA ...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2015.08.024
更新日期：2016-01-01 00:00:00
