Abstract:
:Theta activity has been related to the processing of spatial information and the formation of hippocampus-dependent memory. The medial septum (MS) plays an important role in the control and coordination of theta activity, as well as in the modulation of learning. It has been established that increased serotonergic activity may desynchronize theta activity, while reduced serotonergic activity produces continuous and persistent theta activity in the hippocampus. We investigate whether serotonin acting on the medial septum could modify spatial learning and the functional relationship between septo-hippocampal and septo-mammillary theta activity. The serotonin was depleted (5HT-D) from the medial septum by the injection of 5,7 DHT (5,7- dihydroxytryptamine). Theta activity was recorded in the dorsal hippocampus, MS and mammillary nuclei (SUM, MM) of Sprague-Dawley male rats during spatial learning in the Morris water maze. Spatial learning was facilitated, and the frequency of the hippocampal theta activity during the first days of training increased (to 8.5Hz) in the 5HT-D group, unlike the vehicle group. Additionally, the coherence between the MS-hippocampus and the MS-mammillary nuclei was higher during the second day of the test compared to the vehicle group. We demonstrated that septal serotonin depletion facilitates the acquisition of spatial information in association with a higher functional coupling of the medial septum with the hippocampus and mammillary nuclei. Serotonin, acting in the medial septum, modulates hippocampal theta activity and spatial learning.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Gutiérrez-Guzmán BE,Hernández-Pérez JJ,Olvera-Cortés MEdoi
10.1016/j.bbr.2016.11.017subject
Has Abstractpub_date
2017-02-15 00:00:00pages
73-86eissn
0166-4328issn
1872-7549pii
S0166-4328(16)31038-5journal_volume
319pub_type
杂志文章abstract::Behavioral and neurobiological parallels between rabbits and humans in eyeblink classical conditioning (EBCC) make this paradigm potentially useful for preclinical and clinical trials. The known involvement of hippocampal pyramidal cells in EBCC in rabbits led us to evaluate the nootropic compound, nefiracetam. In Exp...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)86065-2
更新日期:1997-02-01 00:00:00
abstract::Stress elicits relapse to cocaine seeking in humans and in animal models. Cyclic AMP response element binding protein (CREB) is required for swim stress-induced reinstatement of cocaine conditioned place preference. However, the role of CREB in other stress-induced reinstatement models has not been examined. To determ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.02.026
更新日期:2013-06-01 00:00:00
abstract::Our observation that male rat's innate fear response differed with hormonal status, as well as the higher prevalence of fear and anxiety disorders in human females led to the current investigation of the impact of phases of the estrus cycle on innate fear responding. Female rats in different phases of the cycle were e...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.01.019
更新日期:2009-07-19 00:00:00
abstract::Serotonin (5-HT) acts as a neurogenic compound in the developing brain; however serotonin altering drugs such as SSRIs are often prescribed to pregnant and lactating mothers. Early agonism of 5-HT receptors could alter the development of serotonergic circuitry, altering neurotransmission and behaviors mediated by 5-HT...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.07.043
更新日期:2013-09-15 00:00:00
abstract::Voice disorders manifest in the early stages of Parkinson disease (PD), suggesting the vulnerability of the laryngeal sensorimotor system to mild alterations in dopamine signaling. Previous research has demonstrated that manipulations of central dopamine result in acoustic changes in rat ultrasonic vocalization (USV) ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.06.006
更新日期:2013-09-01 00:00:00
abstract::Panic attacks present a high comorbidity with agoraphobia, separation anxiety and generalized anxiety disorder. Nevertheless, while panic attacks have been frequently equated to fear, the relationship of panic disorder with specific phobias remains uncertain. The combination of experimental models of panic and phobias...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.11.042
更新日期:2009-05-16 00:00:00
abstract::Voluntary wheel running in rodents is associated with a number of adaptive behavioral and physiological effects including improved learning, reduction in stress-associated behaviors, neurogenesis, angiogenesis, increases in neurotrophic factors, and changes in several signaling molecules. Exercise has also been report...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.07.036
更新日期:2009-01-30 00:00:00
abstract::The dopamine D2 receptor (D2R) system has been implicated in emotional processing which is often impaired in neuropsychiatric disorders. The long (D2L) and the short (D2S) isoforms of D2R are generated by alternative splicing of the same gene. To study differential roles of the two D2R isoforms, D2L-deficient mice (D2...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.09.007
更新日期:2008-12-22 00:00:00
abstract::Conditioned opiate reward (COR) is rapidly acquired and slowly extinguished. The slow rate of extinction of the salience of drug-related cues contributes to drug craving and relapse. The gamma-aminobutyric acid receptor type B (GABA(B)) agonist, baclofen, attenuates the unconditioned rewarding actions of several drugs...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.10.013
更新日期:2010-03-05 00:00:00
abstract::The outcome of behavioral interactions between organisms can have significant fitness implications. Therefore, it is of great theoretical and practical importance to understand the mechanisms that modify different agonistic behaviors. Changes in central monoamines, such as serotonin (5-HT), contribute to modifying the...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.10.050
更新日期:2014-02-01 00:00:00
abstract::Sleep deprivation (SD) has been reported to induce transient cognitive impairment in functional domains commonly affected in dementia, including memory. Indeed, sleep disturbance has been proposed as an early marker for Alzheimer's disease (AD). SD emulates many aging-related modifications, including important memory ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112066
更新日期:2019-11-05 00:00:00
abstract::According to our previous work, mice of the same strain and age show striking inter-individual differences in behaviour when exposed to a T-maze test. Further, the animals exploring the maze slowly (slow mice) or staying at the starting point (freezing behaviour), which show high levels of emotionality/anxiety in othe...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00449-1
更新日期:2002-08-21 00:00:00
abstract::The mediodorsal nucleus of the thalamus was lesioned in cats, which had learned a spatial delayed-alternation task. Lesions were carried out with kainic acid or ibotenic acid. From altogether 29 cats, 9 cats with bilateral and 6 cats with unilateral lesions of the mediodorsal nucleus together with a control group of 4...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90004-3
更新日期:1982-03-01 00:00:00
abstract::Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant heritability. Individual differences to these responses have been observed across species from rodents to humans. The use of closely related C57B...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112698
更新日期:2020-07-15 00:00:00
abstract::Brain-process foundations of deceptive behaviour have become a subject of intensive study both in fundamental and applied neuroscience. Recently, utilization of transcranial magnetic stimulation has enhanced methodological rigour in this research because in addition to correlational studies causal effects of the disti...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.07.028
更新日期:2011-11-20 00:00:00
abstract::The effects of cerebellar lesions on a classically conditioned eyeblink response was examined using Dutch Belted rabbits as subjects. Results confirmed our previous findings, using New Zealand White rabbits, that cerebellar cortical lesions do not abolish conditioned responding if the interpositus is intact. However, ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90014-0
更新日期:1994-03-31 00:00:00
abstract::Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive deterioration and neuropsychiatric symptoms. Sensorimotor gating deficit has been identified in neuropsychiatric diseases. The aim of the present study was to evaluate the possible sensorimotor gating deficit and its correlation to memo...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.05.007
更新日期:2012-07-15 00:00:00
abstract::The role of the olfactory inputs transmitted by the medial olfactory pathways --i.e. anterior limb of the anterior commissure and medial forebrain bundle-was studied in rats submitted either to a bilateral lesion of the anterior commissure (bAC group) or to a bilateral transection of the lateral olfactory tract follow...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(82)90017-1
更新日期:1982-12-01 00:00:00
abstract::Cancer patients often suffer long-lasting affective and cognitive impairments as a result of chemotherapy treatment. Previous work in our lab has shown deficits in learning and memory and hippocampal cell proliferation in mice lasting up to 20 weeks following acute administration of thioTEPA. In this study, the effect...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.08.046
更新日期:2013-01-01 00:00:00
abstract::S-100 beta, a gene triplicated in Down Syndrome (DS), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. We have been studying an animal model of DS, based on overexpression of this gene. In the current study, we report on the social behaviors of th...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00373-x
更新日期:2003-05-15 00:00:00
abstract::Rearing rats in isolation produces behavioural and neurochemical alterations similar to those observed in schizophrenia. Cannabinoids have also been implicated in inducing psychotic symptoms. In this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid CB(1) recept...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.07.009
更新日期:2006-01-06 00:00:00
abstract::Anxiety was assessed in rats treated with 5mg/kg of PCP bid for 7 days. One week after withdrawal, measures were collected in the light/dark apparatus and during exposure to a cat odor. PCP decreased time spent in the lit area and number of contacts with a cat collar. PCP thus amplified rats' fear of unprotected envir...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.10.017
更新日期:2007-01-25 00:00:00
abstract::We examined the directionality of static and dynamic motor effects on cell discharge recorded during arm movements in motor cortex and area 5. Movements of 8 directions were performed by rhesus monkeys in a two-dimensional space ('movement task'). Static effects were determined using a static hold task in the same wor...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(85)90071-3
更新日期:1985-11-01 00:00:00
abstract::The hippocampus is essentially involved in learning and memory, and is known to be a target for androgen actions. Androgen receptors are densely expressed in CA1 of rat hippocampus, and mediate the effects of testosterone (T) on learning and memory. T depletion or administration can modulate neural function and cognit...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.10.017
更新日期:2008-03-17 00:00:00
abstract::Rivastigmine (RVT) is a reversible inhibitor of cholinesterase approved worldwide for the treatment of cognitive dysfunctions, especially in Alzheimer's disease. Most previous pre-clinical studies have examined the effects of RVT treatment in a wide variety of pathological research models. Nonetheless, the effects of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112077
更新日期:2019-12-30 00:00:00
abstract::Increased proinflammatory cytokines, such as interleukin (IL)-1β, may play an important role in the etiology of depression because they cause the hypothalamic-pituitary-adrenal axis to release glucocorticoids (GC) and induce dysfunction of serotonin and norepinephrine neurotransmission. Sustained increase in GC may ac...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.03.033
更新日期:2018-07-16 00:00:00
abstract::An approximation of the membrane resistance - input resistance - was measured with double-barrelled micropipettes in hindlimb motoneurons during wakefulness and the states of sleep in chronically implanted, restrained cats. During postural atonia in rapid-eye-movement (REM) sleep, motoneurons had a sustained hyperpola...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(81)90060-7
更新日期:1981-03-01 00:00:00
abstract::Unit activity in the medial septal area of the rat was studied during pavlovian appetitive differential conditioning. The firing pattern of cells in the medial septum is that of suppression to presentation of the conditioned excitor and no significant increase to the presentation of the conditioned inhibitor. This pat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(89)80017-8
更新日期:1989-05-01 00:00:00
abstract::The amygdala (AM) and the periaqueductal gray (PAG) represent the rostral and the caudal pole, respectively, of a longitudinally organized neural system, that is responsible for the integration of behavioral and physiological manifestations of defensive reactions against innate and learned threats. Microinjection of b...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(93)90097-a
更新日期:1993-12-20 00:00:00
abstract::It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA rece...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112695
更新日期:2020-07-15 00:00:00