Abstract:
:It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA receptor antagonist MK-801. Second training was then given to amnestic animals with either the same conditioning stimulus (retraining) or a new one (novel training). Retraining with the same stimulus failed to produce efficient memory at all the examined between-training and training-to-test intervals, while a new conditioned stimulus was learned successfully. We suggest that this memory reacquisition deficit may result from the failure of associative memory co-allocation mechanisms.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Tiunova AA,Bezryadnov DV,Gaeva DR,Solodovnikov VS,Anokhin KVdoi
10.1016/j.bbr.2020.112695subject
Has Abstractpub_date
2020-07-15 00:00:00pages
112695eissn
0166-4328issn
1872-7549pii
S0166-4328(20)30394-6journal_volume
390pub_type
杂志文章abstract::Injections of carbachol (CCh) through a chronic cannula into the midbrain periaqueductal grey region (PAG) of the cat induced an emotional-defensive response (EDR) which was evaluated by duration and number of growls in a 30-min experimental session. That response was examined before and after injection of kainic acid...
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