Memory reacquisition deficit: Chicks fail to relearn pharmacologically disrupted associative response.

Abstract:

:It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA receptor antagonist MK-801. Second training was then given to amnestic animals with either the same conditioning stimulus (retraining) or a new one (novel training). Retraining with the same stimulus failed to produce efficient memory at all the examined between-training and training-to-test intervals, while a new conditioned stimulus was learned successfully. We suggest that this memory reacquisition deficit may result from the failure of associative memory co-allocation mechanisms.

journal_name

Behav Brain Res

authors

Tiunova AA,Bezryadnov DV,Gaeva DR,Solodovnikov VS,Anokhin KV

doi

10.1016/j.bbr.2020.112695

subject

Has Abstract

pub_date

2020-07-15 00:00:00

pages

112695

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(20)30394-6

journal_volume

390

pub_type

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