Abstract：
:The present study aimed at determining whether or not the comprehension of symbolic gestures, and corresponding-in-meaning words, makes use of cortical circuits involved in movement execution control. Participants were presented with videos of an actress producing meaningful or meaningless gestures, pronouncing corresponding-in-meaning words or pseudo-words; they were required to judge whether the signal was meaningful or meaningless. Single pulse TMS was applied to forearm primary motor cortex area 150-200 ms after the point when the stimulus meaning could be understood. MEPs were significantly greater when processing meaningless signals as compared to a baseline condition presenting a still-and-silent actress. In contrast, this was not the case for meaningful signals whose motor activation did not differ from that for the baseline stimulus. MEPs were significantly greater for meaningless than meaningful signals and no significant difference was found between gesture and speech. On the basis of these results, we hypothesized that the observation-of/listening-to meaningless signals recruits motor areas. In contrast, this did not occur when the signals were meaningful. Overall, the data suggest that the processes related to comprehension of symbolic gestures and communicative words do not involve primary motor area and probably use brain areas involved in semantics.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Campione GC,De Stefani E,Innocenti A,De Marco D,Gough PM,Buccino G,Gentilucci Mdoi
10.1016/j.bbr.2013.11.025subject
Has Abstractpub_date
2014-02-01 00:00:00pages
297-301eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00712-2journal_volume
259pub_type
杂志文章abstract：:Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. Besides psychiatric, motor and cognitive symptoms, HD patients suffer from sleep disturbances. In order to screen a rat model transgenic for HD (tgHD rats) for sleep-wake cycle dysregulation, we monitored their c...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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