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Impairments in spatial memory retention of GFAP-apoE4 female mice.

Abstract：

:The human apolipoprotein E isoforms, apoE2, apoE3, and apoE4, have differential effects on brain function. Compared to apoE3, apoE4 increases the risk of age-related cognitive decline in humans and female mice expressing apoE in neurons. Here, we show impaired spatial memory retention in female mice expressing apoE4 in astrocytes compared to those expressing apoE3 in astrocytes or lacking apoE. Thus, apoE4 impairs cognition whether expressed in neurons or astrocytes.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

van Meer P,Acevedo S,Raber J

doi

10.1016/j.bbr.2006.10.024

subject

Has Abstract

pub_date

2007-01-25 00:00:00

pages

372-5

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(06)00583-3

journal_volume

176

pub_type

杂志文章

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