Abstract:
:Simultaneous presentation of alternating innocuous warm and cold stimuli induces in most humans a painful sensation called thermal grill illusion (TGI). Here, pain is elicited although nociceptors are not activated. Upon back-translation of behavioural correlates from humans to animals, we found that neither cats nor rodents show adverse reactions when exposed to TGI stimulation. These results question that a TGI observed as a pain-related change in behaviour can be elicited in animals. While distinct neuronal patterns as previously reported may be measurable in animals upon TGI stimulation, their translational meaning towards the sensation elicited in humans is unclear.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Boettger MK,Ditze G,Bär KJ,Krüdewagen EM,Schaible HGdoi
10.1016/j.bbr.2016.07.020subject
Has Abstractpub_date
2016-10-15 00:00:00pages
172-176eissn
0166-4328issn
1872-7549pii
S0166-4328(16)30448-Xjournal_volume
313pub_type
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