Abstract：
:Resting-state networks dissociate in the early stage of Alzheimer's disease (AD). The posterior cingulate cortex (PCC) in AD brain is vulnerable to isolation from the rest of brain. However, it remains unclear how this functional connectivity is related to PCC changes. We employed resting-state functional MRI (fMRI) to examine brain regions with a functional connection to PCC in a mild AD group compared with matched control subjects. PCC connectivity was gathered by investigating synchronic low frequency fMRI signal fluctuations with a temporal correlation method. We found asymmetric PCC-left hippocampus, right dorsal-lateral prefrontal cortex and right thalamus connectivity disruption. In addition, some other regions such as the bilateral visual cortex, the infero-temporal cortex, the posterior orbital frontal cortex, the ventral medial prefrontal cortex and the precuneus showed decreased functional connectivity to the PCC. There were also some regions, primarily in the left frontal-parietal cortices, that showed increased connectivity. These regions included the medial prefrontal cortex, bilateral dorsal-lateral prefrontal cortex, the left basal ganglia and the left primary motor cortex. Impairments to memory, high vision-related functions and olfaction in AD can be explained by a disruption to the functional connection of resting-state networks. The results of increased connectivity may support the compensatory-recruitment hypothesis. Our findings suggest that the characteristics of resting-state functional connectivity could plausibly provide an early imaging biomarker for AD.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Zhang HY,Wang SJ,Xing J,Liu B,Ma ZL,Yang M,Zhang ZJ,Teng GJdoi
10.1016/j.bbr.2008.08.012subject
Has Abstractpub_date
2009-01-30 00:00:00pages
103-8issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00435-Xjournal_volume
197pub_type
杂志文章abstract：:Spatial memory enables us to locate places and objects in space, to determine our position and manage spatial relationships in our environment. Our operations are displayed in a space that sometimes is inaccessible. In this case, the impossibility of movement within the context forces individuals to rely on the inform...
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更新日期：2009-12-07 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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