Abstract：
BACKGROUND:Addiction is a chronic disease characterized by persistent vulnerability to relapse during abstinence. In animal models of addiction, accumulating evidence suggests that exposure to environmental enrichment (EE) during periods of abstinence can have curative effects on addiction and reduce the risks of relapse. However, until present most studies have mainly focused on cocaine. In this study, we investigated whether EE could have beneficial effects on cue-induced seeking for several psychoactive drugs belonging to different pharmacological classes such as methamphetamine (METH), heroin (HER) and nicotine (NIC). METHODS:After self-administration training of METH, HER and NIC, rats were housed in enriched (EE) or standard environments (SE) for 21-28 days of forced abstinence and then drug-seeking behavior was assessed in the absence of the drug. RESULTS:We found that, compared to SE housing, exposure to EE reduced drug seeking behavior for all drugs tested. CONCLUSIONS:These findings suggest that the anti-craving effects of EE are general for a wide variety of drugs and support the hypothesis that environmental stimulation may be a general intervention for attenuating relapse in humans.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Sikora M,Nicolas C,Istin M,Jaafari N,Thiriet N,Solinas Mdoi
10.1016/j.bbr.2017.12.027subject
Has Abstractpub_date
2018-04-02 00:00:00pages
109-113eissn
0166-4328issn
1872-7549pii
S0166-4328(17)31838-7journal_volume
341pub_type
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