abstract：:COR659 is a recently synthesized positive allosteric modulator (PAM) of the GABAB receptor. Similarly to all GABAB PAMs tested to date, COR659 has been reported to suppress different alcohol-related behaviors in rodents. The present study was designed to assess whether the anti-addictive properties of COR659 extend to...

journal_title：Behavioural brain research

authors： Lobina C,Maccioni P,Lorrai I,Zaru A,Collu M,Carai MAM,Brizzi A,Mugnaini C,Gessa GL,Corelli F,Colombo G

更新日期：2021-02-26 00:00:00

abstract：:Anxiety is one of the most common mental disorders worldwide. Currently, the main anti-anxiety drugs, selective serotonin/noradrenalin reuptake inhibitors (SSRIs/SNRIs), are always associated with delayed onset of action and low therapeutic response rate. Benzodiazepines can produce rapid effects, but their long-term ...

journal_title：Behavioural brain research

authors： Fang G,Wang Y

更新日期：2021-02-26 00:00:00

abstract：:Cognitive-behavioral therapy (CBT), a first-line treatment for pediatric anxiety disorders, is based on principles of threat learning and extinction. However, CBT does not work sufficiently for up to 40% of clinically anxious youth. The neural and behavioral correlates of conditioned inhibition might provide promising...

journal_title：Behavioural brain research

authors： Harrewijn A,Kitt ER,Abend R,Matsumoto C,Odriozola P,Winkler AM,Leibenluft E,Pine DS,Gee DG

更新日期：2021-02-05 00:00:00

abstract：:We have previously shown that activity and connectivity within and between the action observation and mentalizing brain systems reflect the degree of positive dimensions expressed by social interactions such as cooperativity and affectivity, respectively. Here we aim to extend this evidence by investigating the neural...

journal_title：Behavioural brain research

authors： Arioli M,Basso G,Carne I,Poggi P,Canessa N

更新日期：2021-02-05 00:00:00

abstract：:Intracellular calcium (Ca2+) homeostasis is a vital process to nerve cell survival and function with an intricate regulatory network. It is well established that the endoplasmic reticulum (ER) is a major intraneuronal Ca2+ storage and that the sarco/endoplasmic reticulum (SR/ER) calcium (Ca2+)-ATPase (SERCA) pump is a...

journal_title：Behavioural brain research

authors： Britzolaki A,Cronin CC,Flaherty PR,Rufo RL,Pitychoutis PM

更新日期：2021-02-05 00:00:00

abstract：:The present study investigated the plausible modulatory role of central histaminergic transmission on the expression of nicotine withdrawal induced anxiety and somatic behavior in mice. Abrupt cessation of chronic nicotine (2 mg/kg, i.p. × 3/day) treatment for 12 days to mice, expressed increased anxiety in light & da...

journal_title：Behavioural brain research

authors： Patel D,Vishwakarma PK,Patel R,Jain NS

更新日期：2021-02-05 00:00:00

abstract：:β-Amyloid (Aβ) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of Alzheimer's disease (AD). Glycogen synthase kinase-3β (GSK-3β) is a key protein kinase implicated in the pathogenesis of AD. Blockade of GSK-3β is an attractive therapeutic strategy for AD. Isoorientin, a 6-C-glycosylflavo...

journal_title：Behavioural brain research

authors： Tan X,Liang Z,Li Y,Zhi Y,Yi L,Bai S,Forest KH,Nichols RA,Dong Y,Li QX

更新日期：2021-02-01 00:00:00

abstract：:Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-in...

journal_title：Behavioural brain research

authors： Felipe JM,Palombo P,Bianchi PC,Zaniboni CR,Anésio A,Yokoyama TS,Engi SA,Carneiro-de-Oliveira PE,Planeta CDS,Leão RM,Cruz FC

更新日期：2021-02-01 00:00:00

abstract：:The burden of depression is enormous, and numerous studies have found that major depressive disorder (MDD) induces cardiovascular disorders (CVD) and functional dyspepsia (FD). Excitingly, meranzin hydrate (MH), an absorbed bioactive compound of Aurantii Fructus Immaturus, reverses psychosocial stress-induced mood dis...

journal_title：Behavioural brain research

authors： Liu X,Zhou J,Zhang T,Chen K,Xu M,Wu L,Liu J,Huang Y,Nie B,Shen X,Ren P,Huang X

更新日期：2021-02-01 00:00:00

abstract：:The mechanism underlying the relationship between autistic traits and social anxiety still remains unknown. It is therefore necessary to investigate potential psychological and biological mechanisms. A total of 3000 college students were samples for this research during 2017-2018. The assessed variables included demog...

journal_title：Behavioural brain research

authors： Yang T,Liu J,Zhang Y,Zhang Q,Shangguan L,Li Z,Luo X,Gong J

更新日期：2021-01-25 00:00:00

abstract：:Low concentrations of ovarian hormones, among other factors, are associated with greater vulnerability to negative effects of environmental stressors and may trigger anxiety symptoms in females. The flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic-like effects in male and ovariectomized female rats, but it i...

journal_title：Behavioural brain research

authors： Rodríguez-Landa JF,Guillén-Ruiz G,Hernández-López F,Cueto-Escobedo J,Rivadeneyra-Domínguez E,Bernal-Morales B,Herrera-Huerta EV

更新日期：2021-01-15 00:00:00

abstract：:This study sought to emphasize how disciplines such as neuroscience and marketing can be applied in advertising and consumer behavior. The application of neuroscience methods in analyzing and understanding human behavior related to the Elaboration Likelihood Model (ELM) and brain activity has recently garnered attenti...

journal_title：Behavioural brain research

authors： Yen C,Chiang MC

更新日期：2021-01-15 00:00:00

abstract：:This study aimed to show the possible protective effects of high intensity interval training (HIIT) in PTSD-induced rats and probable underlying mechanisms. Female rats (n = 44) were separated as; Sedentary (SED), moderate intensity continuous training (MICT), HIIT groups. Then the groups were divided into subgroups a...

journal_title：Behavioural brain research

authors： Koyuncuoğlu T,Sevim H,Çetrez N,Meral Z,Gönenç B,Kuntsal Dertsiz E,Akakın D,Yüksel M,Kasımay Çakır Ö

更新日期：2021-01-15 00:00:00

abstract：:Blending aromatic mixtures components naturally fuse to form a unique odor - a configuration- qualitatively different from each component's odor. Repeated exposure to the components either in the mixture or separately, favors respectively, configural and elemental processings. The neural bases of such processes are st...

journal_title：Behavioural brain research

authors： Sinding C,Hummel T,Béno N,Prescott J,Bensafi M,Coureaud G,Thomas-Danguin T

更新日期：2021-01-06 00:00:00

abstract：:Oxidative stress and the nitric oxide (NO) pathway are involved in the development of opioid analgesic tolerance and dependence. Simvastatin modulates NO and oxidative stress, so the present study aimed to investigate its effect on the development and expression of morphine analgesic tolerance and withdrawal signs in ...

journal_title：Behavioural brain research

authors： Houshmand G,Pourasghar M,Shiran M,Arab Firozjae A,Goudarzi M,Manouchehr F,Shirzad S,Assadpour S,Nikbakht J,Ghorbanzadeh B

更新日期：2021-01-05 00:00:00

abstract：:Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvement...

journal_title：Behavioural brain research

authors： Dutcher AM,Truong KV,Miller DD,Allred RP,Nudi E,Jones TA

更新日期：2021-01-01 00:00:00

abstract：:Recent animal and human studies highlight the uncertainty about the onset of an aversive event as a crucial factor for the involvement of the centromedial amygdala (CM) and bed nucleus of the stria terminalis (BNST) activity. However, studies investigating temporally predictable or unpredictable threat anticipation an...

journal_title：Behavioural brain research

authors： Siminski N,Böhme S,Zeller JBM,Becker MPI,Bruchmann M,Hofmann D,Breuer F,Mühlberger A,Schiele MA,Weber H,Schartner C,Deckert J,Pauli P,Reif A,Domschke K,Straube T,Herrmann MJ

更新日期：2021-01-01 00:00:00

abstract：:The temporoparietal junction (TPJ), along with the anterior insula (AI) and the extrastriate body area (EBA), play a major part in embodiment and self-awareness. However, these connections also appear to be frequently engaged in arousal and attentional processing of external events. Considering that these networks may...

journal_title：Behavioural brain research

authors： Salgues S,Plancher G,Jacquot L,Naveteur J,Fanuel L,Gálvez-García G,Michael GA

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Increased Insulin-like growth factor I (IGF-1) has been associated with improvement of cognitive function in response to exercise. Evidences indicate a role for IGF-1 in beta-amyloid clearance and reducing hyperphosphorylation tau in Alzheimer's disease (AD). There is a need to investigate the IGF-1 response...

journal_title：Behavioural brain research

authors： Stein AM,da Silva TMV,Coelho FGM,Rueda AV,Camarini R,Galduróz RFS

更新日期：2021-01-01 00:00:00

abstract：:Despite increasing evidence that physical activity (PA) contributes to brain health in older individuals, both at the level of brain structure and function, this relationship is not yet well established. To explore this potential association, a systematic literature search was performed using PubMed, Scopus, and Web o...

journal_title：Behavioural brain research

authors： Domingos C,Pêgo JM,Santos NC

更新日期：2020-12-24 00:00:00

abstract：:Adolescents are more likely than adults to develop chronic symptoms, such as impulsivity and difficulty concentrating, following a mild traumatic brain injury (mTBI) which may relate to disruption of pre-frontal cortex (PFC development). During adolescence the PFC is undergoing extensive remodelling, driving maturatio...

journal_title：Behavioural brain research

authors： Kaukas L,Holmes JL,Rahimi F,Collins-Praino L,Corrigan F

更新日期：2020-12-14 00:00:00

abstract：:Depression is the most common psychiatric comorbidity to be diagnosed following traumatic brain injury (TBI). In clinical populations, TBI-induced depression may be particularly difficult to treat due to both unique underlying causes and the propensity for treatment resistance. Preclinical assays are needed to charact...

journal_title：Behavioural brain research

authors： Frankot M,O'Hearn C,Vonder Haar C

更新日期：2020-10-01 00:00:00

abstract：:Current estimates indicate that millions of people in the United States abuse opioid drugs, which may also affect their offspring. To determine whether parental exposure to morphine alters reward and affective behaviors in subsequent generations we exposed male and female C57BL/6NTac mice to morphine (75 mg) or placeb...

journal_title：Behavioural brain research

authors： Brynildsen JK,Sanchez V,Yohn NL,Carpenter MD,Blendy JA

更新日期：2020-10-01 00:00:00

abstract：:Physical exercise could be a protective factor against the development of substance use disorders; however, a number of preclinical studies report reward-enhancing effects of exercise for various drugs of abuse. We examined the effects of chronic wheel-running on brain reward sensitivity, reaction to novelty, reward-f...

journal_title：Behavioural brain research

authors： Katsidoni V,Tzatzarakis MN,Karzi V,Thermos K,Kastellakis A,Panagis G

更新日期：2020-09-15 00:00:00

abstract：:The long-standing hypothesis that memory consolidation is dependent upon de novo protein synthesis is based primarily on the amnestic effects of systemic administration of protein synthesis inhibitors (PSIs). Early experiments on mice showed that PSIs produced interference with memory consolidation that was dependent ...

journal_title：Behavioural brain research

authors： Prado-Alcalá RA,González-Salinas S,Antaramián A,Quirarte GL,Bello-Medina PC,Medina AC

更新日期：2020-09-01 00:00:00

abstract：:Being cautious of unfamiliar conspecifics is adaptive because sick or aggressive conspecifics may jeopardize survival and well-being. However, prolonged or excessive caution, i.e. fear related to social situations, is maladaptive and may result in social anxiety disorder. Some anxiety disorders in humans are associate...

journal_title：Behavioural brain research

authors： Kolodziejczyk MH,Faesel N,Koch M,Fendt M

更新日期：2020-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a prevalent neurodegenerative disease that is highly comorbid with depression. Gut dysfunction has been proposed as a possible risk factor for both clinical conditions. In the present study, we investigated the ability of treadmill exercise for 4 weeks (5 days/week, 40 min/day) to counterac...

journal_title：Behavioural brain research

authors： Rosa JM,Pazini FL,Camargo A,Wolin IAV,Olescowicz G,Eslabão LB,Romero OB,Winkelmann-Duarte EC,S Rodrigues AL

更新日期：2020-09-01 00:00:00

abstract：:The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use as an anti-epileptic. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory i...

journal_title：Behavioural brain research

authors： Marks WN,Zabder NK,Snutch TP,Howland JG

更新日期：2020-09-01 00:00:00

abstract：:Probabilistic learning is a fundamental cognitive ability that extracts and represents regularities of our environment enabling predictive processing during perception and acquisition of perceptual, motor, cognitive, and social skills. Previous studies show competition between neural networks related to executive func...

journal_title：Behavioural brain research

authors： Zavecz Z,Horváth K,Solymosi P,Janacsek K,Nemeth D

更新日期：2020-09-01 00:00:00

abstract：:Intake despite negative consequences (compulsivity) contributes strongly to the harm of alcohol use disorder, making the underlying psychological and circuit mechanisms of great importance. To gain insight into possible underlying action strategies, we compared rat licking microstructure across compulsion-like and non...

journal_title：Behavioural brain research

authors： Darevsky D,Hopf FW

更新日期：2020-09-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signaling in the hippocampus regulates psychiatric behaviors and hippocampal neurogenesis in non-stress conditions; however, stress-induced changes in hippocampal BMP signaling have not yet been reported. Therefore, we sought to examine whether psychosocial stress, which induces psychi...

journal_title：Behavioural brain research

authors： Mori M,Murata Y,Tsuchihashi M,Hanakita N,Terasaki F,Harada H,Kawanabe S,Terada K,Matsumoto T,Ohe K,Mine K,Enjoji M

更新日期：2020-08-17 00:00:00

abstract：PURPOSE:To explore the effect of vagal nerve stimulation (VNS) on spontaneous brain activity in patients with drug-resistant epilepsy (DRE). METHODS:15 patients and eight healthy controls (HC) were enrolled and scanned by resting-state functional MRI to investigate changes in the fractional amplitude of low-frequency ...

journal_title：Behavioural brain research

authors： Zhu J,Xu C,Zhang X,Qiao L,Wang X,Zhang X,Yan X,Ni D,Yu T,Zhang G,Li Y

更新日期：2020-08-17 00:00:00

abstract：:Taste recognition memory in rodents is evident as taste neophobia disappears upon repeated taste exposures without aversive consequences, thus increasing the consumption of familiar edibles. The attenuation of taste neophobia (AN) induced by taste familiarity is auditory context-dependent in mice since neophobia to a ...

journal_title：Behavioural brain research

authors： Grau-Perales AB,Gallo M

更新日期：2020-08-05 00:00:00

abstract：:Exposure to maternal high-fat (HF) diet during gestation and lactation alters adult offspring's feeding behavior and diet preference. However, the impact of maternal exercise on offspring's diet preference and reward system development is less studied. In this study, we investigate the effect of perinatal maternal exe...

journal_title：Behavioural brain research

authors： Song L,Cui J,Wang N,Wang R,Yan J,Sun B

更新日期：2020-07-15 00:00:00

abstract：:Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant heritability. Individual differences to these responses have been observed across species from rodents to humans. The use of closely related C57B...

journal_title：Behavioural brain research

authors： Ulker E,Caillaud M,Patel T,White A,Rashid D,Alqasem M,Lichtman AH,Bryant CD,Damaj MI

更新日期：2020-07-15 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a clinically and progressive loss of cognitive function, neuropsychiatric and behavioral disorders. Some studies showed that chrysin has antioxidant and anti-inflammatory properties. However, your bioavailability is relatively low. Therefore, th...

journal_title：Behavioural brain research

authors： Giacomeli R,de Gomes MG,Reolon JB,Haas SE,Colomé LM,Jesse CR

更新日期：2020-07-15 00:00:00

abstract：:It is generally assumed that if memory is disrupted by pharmacological inhibitors during its consolidation, it can be later acquired afresh. In our experiments, we trained day-old chicks in a one-trial passive avoidance task and interfered with memory formation using protein synthesis inhibitor anisomycin or NMDA rece...

journal_title：Behavioural brain research

authors： Tiunova AA,Bezryadnov DV,Gaeva DR,Solodovnikov VS,Anokhin KV

更新日期：2020-07-15 00:00:00

abstract：:Ketamine, a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, produces quick and effective antidepressant results in depressed juvenile and adult individuals. The long-term consequences of using ketamine in juvenile populations are not well known, particularly as it affects vulnerability to drugs of abus...

journal_title：Behavioural brain research

authors： Franco D,Zamudio J,Blevins KM,Núñez-Larios EA,Ricoy UM,Iñiguez SD,Zavala AR

更新日期：2020-07-01 00:00:00

abstract：:Is addiction a medical disorder, and if so, what kind of disorder is it? Addiction is considered a brain disease by NIDA, based on observed brain changes in addicts that are interpreted as brain damage. Critics argue that the brain changes result instead from normal neuroplasticity and learning in response to the inte...

journal_title：Behavioural brain research

authors： Wakefield JC

更新日期：2020-07-01 00:00:00

abstract：:Early life adversity in humans is linked to cognitive deficits and increased risk of mental illnesses, including depression, bipolar disorder, and schizophrenia, with evidence for different vulnerabilities in men versus women. Modeling early life adversity in rodents shows similar neuropsychological deficits that may ...

journal_title：Behavioural brain research

authors： Soares AR,Gildawie KR,Honeycutt JA,Brenhouse HC

更新日期：2020-06-18 00:00:00