Abstract:
INTRODUCTION:Several human studies have reported that coffee consumption improves cognitive performance. In the present study, we investigated whether instant decaffeinated coffee also ameliorates cognitive performance and attenuates the detrimental effects of scopolamine on memory. METHODS:Memory performance was evaluated in Morris water maze test and passive avoidance test. Instant decaffeinated coffee (p.o.) at 120 or 240 mg/kg in Sprague-Dawley rats, which is equivalent to approximately three or six cups of coffee, respectively, in a 60 kg human, was administered for two weeks. RESULTS:Oral gavage administration of instant decaffeinated coffee inhibited scopolamine-induced memory impairment, which was measured by Morris water maze test and passive avoidance test. Instant decaffeinated coffee suppressed scopolamine-mediated elevation of tumor necrosis factor-α (TNF-α) and stimulation of nuclear factor-κB (NF-κB) pathway (i.e., phosphorylation of IκBα and p65) in the rat hippocampus. DISCUSSION:These findings suggest that caffeine-free decaffeinated coffee may prevent memory impairment in human through the inhibition of NF-κB activation and subsequent TNF-α production.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Jang YJ,Kim J,Shim J,Kim CY,Jang JH,Lee KW,Lee HJdoi
10.1016/j.bbr.2013.02.003subject
Has Abstractpub_date
2013-05-15 00:00:00pages
113-9eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00077-6journal_volume
245pub_type
杂志文章abstract::Microglia have a pivotal role to initiate immune responses in AD brains through toll-like receptors and induce neuroinflammation. Adipose tissue mesenchymal stem cells (ATSCs) secret many neurotrophic and anti-inflammatory factors called conditioned medium (CM). Many studies have demonstrated that CM of mesenchymal st...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112362
更新日期:2020-02-03 00:00:00
abstract::3,4-Dihydroxy-l-phenylalanine (l-Dopa) remains the most effective drug for treating the motor symptoms of Parkinson's disease (PD). However, its long-term use is limited due to motor complications such as wearing-off and dyskinesia. A clinical study in PD patients with motor complications has demonstrated that selegil...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.03.002
更新日期:2018-07-16 00:00:00
abstract::The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. These disorders feature high levels of comorbidity and share an overlap of symptoms; in particular, deficits in social functioning...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.03.032
更新日期:2019-07-23 00:00:00
abstract::Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.111947
更新日期:2019-09-16 00:00:00
abstract::Individual differences in coping response lie at the core of vulnerability to conditions like post-traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.08.014
更新日期:2009-12-28 00:00:00
abstract::Proper understanding of motor control requires insight into the extent and manner in which task performance and control strategy are influenced by various aspects of visual information. We therefore systematically manipulated the visual presentation (i.e., scaling factor and optical flow density) of a visuomotor track...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.04.056
更新日期:2017-06-30 00:00:00
abstract::Recognizing and categorizing visual stimuli are cognitive functions vital for survival, and an important feature of visual systems in primates as well as in birds. Visual stimuli are processed along the ventral visual pathway. At every stage in the hierarchy, neurons respond selectively to more complex features, trans...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.05.014
更新日期:2019-01-01 00:00:00
abstract::Two cortical areas in rats have been found to be important in directed attention and spatial processing: the medial agranular cortex (AGm), the rodent analog of the frontal eye fields; and the posterior parietal cortex (PPC), the rodent analog of area 7 in primates. As in primates, unilateral destruction of either of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)02241-3
更新日期:1997-06-01 00:00:00
abstract::Cocaine-induced hyperactivity was inhibited by a single administration of naloxone (2 and 5 mg/kg, i.p.), an opioid receptor antagonist, and naloxone administered prior to and during the chronic injection of cocaine attenuated the development of both cocaine-induced reverse tolerance and conditioned place preference (...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)00162-3
更新日期:1997-04-01 00:00:00
abstract::Attention to addiction of women alone for fetus and infant's health has caused the possible role of father's status was less considered, while some developmental impairments including decrease of liter size, weight loss, congenital deficiencies, behavioral disorders, and learning and memory impairments in offspring wi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.041
更新日期:2008-01-10 00:00:00
abstract::Social impairments in autism remain poorly understood and without approved pharmacotherapies. Novel animals models are needed to elucidate mechanisms and evaluate novel treatments for the social deficits in autism. Recently, serotonin 1B receptor (5-HT1B) agonist challenge in mice was shown to induce autism-like behav...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.07.027
更新日期:2016-11-01 00:00:00
abstract::In a recent study with the Poffenberger paradigm, Brizzolara et al. reported longer estimates of interhemispheric transfer time (IHTT) for children aged 7 years than for adults. They interpreted this finding as evidence for incomplete functional maturity of the corpus callosum in young children. The present study was ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)02261-9
更新日期:1997-07-01 00:00:00
abstract::Regulation of CNS arousal is important for a wide variety of functions, including the initiation of all motivated behaviors. Usually studied with pharmacological or hormonal tools, CNS arousal can also be elevated by deep brain stimulation (DBS), in the human brain and in animals. The effectiveness of DBS is conventio...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.06.009
更新日期:2010-12-25 00:00:00
abstract::The present work was aimed to evaluate the contribution of interoception to the autonomic and behavioral responses to hypoxia. To address this issue, we studied whether the inactivation of the primary interoceptive posterior insular cortex (pIC) may disrupt the autonomic and behavioral effects of hypoxia in conscious ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.07.015
更新日期:2013-09-15 00:00:00
abstract::Bizarre behaviors (stereotyped stretching, stereotyped rearing, backward movements and jumps) were conspicuously elicited in classical unconditioned tests with different levels of anxiogenic conditions. They were characterized for the first time as early-BPSD-like symptoms in 6 month-old male and female 3xTg-AD mice. ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.10.017
更新日期:2014-01-01 00:00:00
abstract::The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompa...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90168-7
更新日期:1983-04-01 00:00:00
abstract::The present research studied the influence of an early chronic variable stress (CVS) paradigm - an animal model of depression - on behavioral responses to subsequent environmental challenges suggested to model anhedonia and emotional reactions such as anxiety and fear. In order to explore a potential involvement of an...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00302-8
更新日期:2000-12-20 00:00:00
abstract::Progression through neuronal loss of substantia nigra pars compacta (SNpc) with Parkinson's disease depends on various protein post-translational modifications mainly comprising ubiquitination. Although many ubiquitination sites have been identified through site-specific methods, systematic quantitative proteomic anal...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112436
更新日期:2020-02-17 00:00:00
abstract::Experimental and clinical studies have generally shown that the neural mechanisms for face processing in man are (1) designed to deal with the configuration of upright faces and (2) located predominantly in the right cerebral hemisphere. Monkeys would seem to process faces in a different manner to humans since they ap...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90029-0
更新日期:1988-08-01 00:00:00
abstract::Air and light pollution contribute to fetal abnormalities, increase prevalence of cancer, metabolic and cardiorespiratory diseases, and central nervous system (CNS) disorders. A component of air pollution, particulate matter, and the phenomenon of dim light at night (dLAN) both result in neuroinflammation, which has b...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.07.033
更新日期:2015-11-01 00:00:00
abstract::Adolescents are more likely than adults to develop chronic symptoms, such as impulsivity and difficulty concentrating, following a mild traumatic brain injury (mTBI) which may relate to disruption of pre-frontal cortex (PFC development). During adolescence the PFC is undergoing extensive remodelling, driving maturatio...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.113067
更新日期:2020-12-14 00:00:00
abstract::Spatial memory enables us to locate places and objects in space, to determine our position and manage spatial relationships in our environment. Our operations are displayed in a space that sometimes is inaccessible. In this case, the impossibility of movement within the context forces individuals to rely on the inform...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.03.022
更新日期:2018-07-16 00:00:00
abstract::The validity of the hypothesis put forward earlier, that testicular secretions during puberty have an organizing effect on open field ambulation was examined. Male rats were castrated or sham-operated at days 21, 43 or 70. At the age of 17 weeks the males were tested in an automated, octagonal open field (3 consecutiv...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90141-6
更新日期:1988-09-15 00:00:00
abstract::Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA(A) receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.12.010
更新日期:2008-05-16 00:00:00
abstract::This study was designed to separate the neural response associated with awareness of a visual object from the neural responses to the visual input without awareness. Two classes of stimuli were presented to subjects: (1) a field of randomly positioned and oriented Gabor patches (no contour) or (2) the same field of Ga...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2008.07.026
更新日期:2009-01-03 00:00:00
abstract::Binge eating is a dysregulated form of feeding behavior that occurs in multiple eating disorders including binge-eating disorder, the most common eating disorder. Feeding is a complex behavioral program supported through the function of multiple brain regions and influenced by a diverse array of receptor signaling pat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.03.046
更新日期:2016-07-01 00:00:00
abstract::Visuo-spatial learning and memory were assessed in male and female mice of 13 inbred strains on a small diameter mouse version of the Barnes maze surrounded by a wall and intra-maze visual cues. Mice completed acquisition and reversal training to assess learning, followed by a probe test to assess memory for the spati...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.08.030
更新日期:2011-01-20 00:00:00
abstract::Though accumulating literature implicates that cytokines are involved in the pathophysiology of mental disorders, the role of interleukin-6 (IL-6) in learning and memory functions remains unresolved. The present study was undertaken to investigate the effect of IL-6 on amygdala-dependent fear learning. Adult Wistar ra...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.052
更新日期:2014-12-15 00:00:00
abstract::We postulated that gradual muscle relaxation during motor learning would dynamically change activity in the primary motor cortex (M1) and modify short-interval intracortical inhibition (SICI). Thus, we compared changes in M1 excitability both pre and post motor learning during gradual muscle relaxation. Thirteen healt...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.09.001
更新日期:2016-01-01 00:00:00
abstract::The endocannabinoid system is capable of modulating multiple physiological brain functions including learning and memory. Moreover, there is evidence that the processes of acquisition and consolidation have distinct biological basis. We used the cannabinoid agonist WIN 55,212-2 (WIN-2) to investigate whether chronic C...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112231
更新日期:2020-01-13 00:00:00