Abstract：
:Individual differences in coping response lie at the core of vulnerability to conditions like post-traumatic stress disorder (PTSD). Like humans, not all animals exposed to severe stress show lasting change in affect. Predator stress is a traumatic experience inducing long-lasting fear, but not in all rodents. Thus, individual variation may be a cross species factor driving responsiveness to stressful events. The present study investigated neurobiological bases of variation in coping with severe stress. The amygdala was studied because it modulates fear and its function is affected by stress. Moreover, stress-induced plasticity of the amygdala has been related to induction of anxiety, a comorbid symptom of psychiatric conditions like PTSD. We exposed rodents to predator stress and grouped them according to their adaptability based on a standard anxiety test (the elevated plus maze). Subsequently we investigated if well-adapted (less anxious) and mal-adapted (extremely anxious) stressed animals differed in the structure of dendritic trees of their output neurons of the right basolateral amygdala (BLA). Two weeks after exposure to stress, well-adapted animals showed low anxiety levels comparable to unstressed controls, whereas mal-adapted animals were highly anxious. In these same animals, Golgi analysis revealed that BLA neurons of well-adapted rats exhibited more densely packed and shorter dendrites than neurons of mal-adapted or unstressed control animals, which did not differ. These data suggest that dendritic hypotrophy in the BLA may be a resilience marker against lasting anxiogenic effects of predator stress.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Mitra R,Adamec R,Sapolsky Rdoi
10.1016/j.bbr.2009.08.014subject
Has Abstractpub_date
2009-12-28 00:00:00pages
535-43issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(09)00483-5journal_volume
205pub_type
杂志文章abstract：:The concept of a rat-robot was initially introduced in 2002, bringing to the field, a novel area of research using modern research into neuroscience and robotics. This paper brings to the table, a study into the method best used for navigation systems in a rat-robot. Current research is epitomized by the use of reward...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(86)90020-3
更新日期：1986-03-01 00:00:00
abstract：:In the hippocampus of freely moving rats, neurons have been recorded that fire predominantly when the animal travels through a particular area while exploring the environment (so-called 'place cells'). This study investigates if the neuronal firing characteristics of such cells are modulated by attention, expectation ...
journal_title：Behavioural brain research
pub_type： 杂志文章
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abstract：:This review gives an overview of those in vivo imaging studies on synaptic neurotransmission, which so far have been performed on patients with movement disorders and/or dementia. Thereby, the focus is on disease-related deficiencies within the functional entity of the dopaminergic, serotonergic, cholinergic, glutamat...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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abstract：:Recent investigations report a higher risk of motor symptoms in females with the FMR1 premutation (PM-carriers) than has hitherto been appreciated. Here we examined basic sensorimotor and postural control under different sensory and attentional dual-task demands. Physiological performance and postural sway measures fr...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2020.112994
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2005.03.010
更新日期：2005-07-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-12-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1991-02-28 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
abstract：:The incidence of stress and stress-related disorders with the transition to motherhood, such as postpartum depression, is estimated to be 20%. Selective serotonin reuptake inhibitor (SSRI) medications are currently the antidepressant of choice to treat maternal mood disorders. However, little is known about the effect...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.11.043
更新日期：2012-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.052
更新日期：2010-12-06 00:00:00
abstract：:A rat model of novelty-seeking phenotype predicts vulnerability to nicotine relapse where locomotor reactivity to novelty is used to rank high (HR) versus low (LR) responders. Present study investigates implication of cannabinoid receptor 1 (CB1R) in the basolateral (BLA) and the central (CeA) nuclei of amygdala in be...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.11.015
更新日期：2012-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(02)00345-5
更新日期：2003-05-15 00:00:00
abstract：:This study was designed to separate the neural response associated with awareness of a visual object from the neural responses to the visual input without awareness. Two classes of stimuli were presented to subjects: (1) a field of randomly positioned and oriented Gabor patches (no contour) or (2) the same field of Ga...
journal_title：Behavioural brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.bbr.2008.07.026
更新日期：2009-01-03 00:00:00
abstract：:Exposure to repeated stress can lead to diverse and widespread behavioral consequences, including reduction in food and water intake and subsequent diminution in weight gain. Many reports have suggested that repeated stress substantially alters the neurochemistry, morphology and physiology of neurons within the bed nu...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.11.010
更新日期：2012-02-01 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2016.01.007
更新日期：2016-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2020-03-02 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(85)90165-2
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2017-09-29 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.10.023
更新日期：2011-03-01 00:00:00
abstract：:Forty-six stumptail monkeys were tested for hand preference on a simple reaching task. Initial repeated reaches with the hand chosen for the first reach went unrewarded. All reaches following and including the earliest reach with the opposite hand were rewarded and were used to calculate overall hand preference for th...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(80)90009-1
更新日期：1980-12-01 00:00:00
abstract：:Receptors for glucocorticoid (GR) and corticotropin-releasing hormone (CRH) are largely found in brain sensorimotor structures, particularly in cerebellum, underlining a potential role of stress hormones in the regulation of motor function. Since CRH is involved in neuroplasticity, known for its trophic effect on syna...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.02.035
更新日期：2017-05-30 00:00:00
abstract：:In the USA, the stimulant drug methylphenidate (MPH) is used to treat a large number (2 million or more per year) of children with Attention Deficit Hyperactivity Disorder (ADHD). Although the US FDA approved MPH in the 1960s, the pharmacokinetic (PK) properties of serum concentrations of MPH in children with ADHD wer...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2002-03-10 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(87)90071-4
更新日期：1987-09-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.12.014
更新日期：2012-03-17 00:00:00
abstract：:Neuregulin 1 (NRG1) is an important growth factor involved in the development and plasticity of the central nervous system. Since its identification as a susceptibility gene for schizophrenia, several transgenic mouse models have been employed to elucidate the role NRG1 may play in the pathogenesis of psychiatric dise...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.05.008
更新日期：2011-10-31 00:00:00
abstract：:The effects of two cognition enhancers on avoidance impairment induced by the tricyclic antidepressant amitriptyline were assessed during shuttle-box avoidance acquisition and in previously trained mice of the DBA/2 strain. The nootropic agent piracetam (50, 100 or 200 mg/kg, i.p.) had slight or no effect in mice rece...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)00066-1
更新日期：1997-12-01 00:00:00
