Abstract:
:This review gives an overview of those in vivo imaging studies on synaptic neurotransmission, which so far have been performed on patients with movement disorders and/or dementia. Thereby, the focus is on disease-related deficiencies within the functional entity of the dopaminergic, serotonergic, cholinergic, glutamatergic, GABAergic or opioid synapse. In vivo investigations have yielded highly consistent results on the dysfunction of synaptic constituents in the majority of diseases covered by this overview. Findings show presynaptic dysfunctions in idiopathic as well as early-onset Parkinson's disease with decreases in striatal dopamine synthesis (57 out of a total of 59 reports on both types of Parkinson's disease), storage (nine out of nine reports), release (two out of three reports) and transporter binding (95 out of 95 reports). In contrast, the "Parkinson plus" syndromes multiple system atrophy and progressive supranuclear palsy are characterized by both pre- and postsynaptic deficiencies with reductions in striatal dopamine synthesis (11 out of a total of 11 reports on both types of "Parkinson plus" syndromes), storage (four of four reports), and transporter binding (27 out of 27 reports) as well as D1 (two out of two reports) and D2 receptor binding (34 out of 36 reports). This does not hold for the "Parkinson plus" syndromes dementia with Lewy bodies and corticobasal degeneration. For these diseases, for the time being, firm evidence of alterations in D1 and/or D2 receptor binding is lacking. In patients with Huntington's disease, mainly postsynaptic dysfunctions with reductions of striatal D1 (six out of six reports) and D2 receptor binding (15 out of 15 reports) were observed. Alzheimer's disease is characterized by both pre-and postsynaptic deficiencies of the cholinergic system with decreases of cortical acetylcholine storage (one out of two reports) and both musarinic (seven out of 10 reports) and nicotinic cholinergic receptor binding (three out of six reports). Moreover, reductions in cortical (one out of three reports) and limbic 5-HT1A (three out of three reports) and cortical (four out of four reports) and limbic 5-HT2A receptor binding (one out of two reports) were observed. Moreover, there is evidence for a cortical (four out of six reports) and cingulate (three out of three reports) increase of peripheral benzodiazepine receptor binding indicative of microglial activation. In the majority of investigations on patients with Alzheimer's disease, no alterations of presynaptic dopamine function were found, whereas all other forms of dementia including corticobasal degeneration, dementia with Lewy bodies, Parkinson's disease dementia and frontotemporal dementia were characterized by presynaptic dopaminergic deficiencies with reductions in striatal dopamine synthesis (10 out of a total of 10 reports on these types of dementia), storage (four out of four reports) and transporter binding (29 out of 29 reports). Taken together, in vivo imaging methods can be employed for the diagnosis of idiopathic and early-onset Parkinson's disease as well as "Parkinson plus" syndromes and Huntington's disease. Moreover, differentiation is feasible between, firstly, Parkinson's disease and the "Parkinson plus" syndromes multiple system atrophy and progressive supranuclear palsy, secondly, multiple system atrophy/progressive supranuclear palsy and the other "Parkinson plus" syndromes dementia with Lewy bodies and corticobasal degeneration, and, thirdly, Alzheimer's disease and other forms of dementia.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Nikolaus S,Antke C,Müller HWdoi
10.1016/j.bbr.2009.06.008subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1-31issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(09)00354-4journal_volume
204pub_type
杂志文章,评审abstract::Behavioral experience, in the form of skilled limb use, has been found to impact the structure and function of the central nervous system, affecting post-stroke behavioral outcome in both adaptive and maladaptive ways. Learning to rely on the less-affected, or non-paretic, body side is common following stroke in both ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.05.062
更新日期:2013-09-01 00:00:00
abstract::Three experiments examined appetitive trace and delay conditioning of the licking response (LR). In Experiment 1, normal rats were trained in trace conditioning using different trace intervals (2, 4, or 8s) and in delay conditioning (i.e., with a 0-s trace) in order to determine an appropriate trace interval for the f...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.07.004
更新日期:2007-12-11 00:00:00
abstract::Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00207-8
更新日期:2001-09-14 00:00:00
abstract::We developed a method to quantify the probability of a target neuron discharge following synchronous or asynchronous discharges among a pair of reference neurons. To illustrate this method, we simultaneously recorded three neurons having overlapping receptive fields in the somatosensory system: two reference neurons i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00165-1
更新日期:2002-09-20 00:00:00
abstract::Previous studies with mice lacking 5-HT(1A) (1AKO) and 5-HT(1B) (1BKO) receptors in hippocampus-dependent learning and memory paradigms, suggest that these receptors play an important role in learning and memory, although their precise role is unclear. In the present study, 1AKO and 1BKO mice were studied in operant b...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00345-5
更新日期:2003-05-15 00:00:00
abstract::Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long histor...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2014.09.001
更新日期:2015-05-15 00:00:00
abstract::Drug addiction is a chronic mental disorder characterized by frequent relapses. Contextual cues associated with drug use to play a critical causal role in drug-seeking behavior. The hippocampus has been implicated in encoding drug associative memories. Here we examine whether the dorsal hippocampus mediates context-in...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112978
更新日期:2021-02-01 00:00:00
abstract::In order to outline the involvement of the hippocampus in behavior and memory functions the results of grafting experiments in the hippocampal formation are presented in addition to former lesion and stimulation studies. Grafts of fetal hippocampal tissue were found to induce short-term beneficial effects on learning ...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(94)00125-y
更新日期:1995-01-23 00:00:00
abstract::We have investigated the interaction between opioid peptides and dopaminergic A10 (DA-A10) neurones in the ventral tegmental area (VTA). The behavioural consequences of VTA infusion of d-Ala-Met-enkephalinamide (DALA) were analyzed. DALA elicited a dose-dependent increase in locomotor activity measured in photocell ca...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(80)90043-1
更新日期:1980-02-01 00:00:00
abstract::Cognitive deficits are a particularly debilitating symptom group in schizophrenia. We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice. Male and female heterozygous reelin mice (HRM) and wild-type (W...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.03.063
更新日期:2015-01-01 00:00:00
abstract::We investigated the neurobiological bases of variation in response to predator stress (PS). Sixteen days after treatment (PS or handling), rats were grouped according to anxiety in the elevated plus maze (EPM). Acoustic startle was also measured. We examined the structure of dendritic trees of basolateral amygdala (BL...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.09.009
更新日期:2012-01-01 00:00:00
abstract::Maternal alcohol consumption during pregnancy may cause neurocognitive and behavioral disorders that can persist until adulthood. Epidemiological data has revealed an alarming increase in the frequency of alcohol intake in pregnant women. Nutritional variables may also have an impact on the behavioral alterations occa...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112022
更新日期:2019-10-17 00:00:00
abstract::Two cortical areas in rats have been found to be important in directed attention and spatial processing: the medial agranular cortex (AGm), the rodent analog of the frontal eye fields; and the posterior parietal cortex (PPC), the rodent analog of area 7 in primates. As in primates, unilateral destruction of either of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)02241-3
更新日期:1997-06-01 00:00:00
abstract::One of the most widely used animal models for assessing recovery of locomotor functioning is the spinal rat. Although true differences in locomotor abilities of these animals are exhibited during treadmill testing, current measurement techniques often fail to detect them. The HiJK (Hillyer-Joynes Kinematics) scale was...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.04.009
更新日期:2009-09-14 00:00:00
abstract::Relapse to drug use following prolonged periods of abstinence results, in part, from the ability of contextual cues paired previously with self-administered drug to elicit drug craving and -seeking behavior. Given the popularity of the mouse for the genetic analysis of drug-induced behaviors, a place conditioning mode...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00102-x
更新日期:2002-10-17 00:00:00
abstract::The aim of present research was to analyze the temporal structure of rodent's anxiety-related behavior in hole-board apparatus (HB). Fifteen male Wistar rats were tested for 10 min. Video files, collected for each subject, were coded by means of a software coder and event log files generated for each subject. To asses...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.11.013
更新日期:2010-03-17 00:00:00
abstract::In this study we examined behavioral sleep in the walrus, the only living species of the family Odobenidae. The behavior of four 1.5-2-year-old captive walruses was videotaped continuously for 7-17 days and scored in 1-min epochs. When walruses had access to water and land, behavioral sleep, the combined amount of qui...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.01.033
更新日期:2009-07-19 00:00:00
abstract::The zebrafish (Danio rerio) has become an excellent tool to study mental health disorders, due to its physiological and genetic similarity to humans, ease of genetic manipulation, and feasibility of small molecule screening. Zebrafish have been shown to exhibit characteristics of addiction to drugs of abuse in non-con...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.08.001
更新日期:2017-09-29 00:00:00
abstract::This work examines the autoradiographic distribution of serotonin (5-HT) receptor subtypes in rat, guinea pig and human brain, using [3H]5-HT and [3H]5-CT as ligands. Different displacers were used to mask radioligand binding to 5-HT1A, 5-HT1B/1D and 5-HT2C receptors, in an attempt to visualize other receptor populati...
journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章
doi:10.1016/0166-4328(96)00104-0
更新日期:1996-01-01 00:00:00
abstract::Like human prehensile behavior, the pigeon's ingestive pecking response is elicited by visual stimuli conveying information about the location and size of the target. This information is used to generate localized ingestive pecks whose gapes are amplitude-scaled to seed size, prior to contact. We employed high-resolut...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)00121-6
更新日期:1998-03-01 00:00:00
abstract::Autism is a heterogeneous, behaviorally defined developmental disorder with unknown etiology but thought to be the result of environmental insult acting upon the developing brain of a genetically susceptible individual. Approximately 30% of individuals with autism have normal development up to the age of about 30 mont...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.02.032
更新日期:2010-07-11 00:00:00
abstract::Blending aromatic mixtures components naturally fuse to form a unique odor - a configuration- qualitatively different from each component's odor. Repeated exposure to the components either in the mixture or separately, favors respectively, configural and elemental processings. The neural bases of such processes are st...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.113088
更新日期:2021-01-06 00:00:00
abstract::The thalamofugal visual projections of the chick are known to develop in response to stimulation by light prior to hatching, and asymmetry in the number of projections develops as a consequence of the embryo being oriented in the egg so that it occuludes its left eye. The right eye only is stimulated by light and this...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(96)00021-6
更新日期:1996-10-01 00:00:00
abstract::Studies of extinction in preweanling rats have failed to find ABA-renewal in a fear conditioning paradigm. This result supports the hypothesis postulating ontogenetic qualitative differences in experimental extinction. A similar result in adult rats led to the conclusion that ABA-renewal requires contexts A and B to d...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.07.027
更新日期:2013-09-15 00:00:00
abstract::Between April 2007 and December 2015, the Veterans Health Administration (VHA) screened one million combat veterans for traumatic brain injury (TBI), among 2.6 million deployed during operations Enduring Freedom, Iraqi Freedom and New Dawn (OEF/OIF/OND). Since 2007, among those reporting, screened and referred for def...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2016.08.036
更新日期:2018-03-15 00:00:00
abstract::Iron is the most common micronutrient deficiency in the world and it is most prevalent in young children, exposing their developing brain to inadequate iron levels. The damage related to neuroanatomical parameters is not reversed after iron treatment. However, evidence suggest that tactile stimulation (TS) may offer g...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112357
更新日期:2020-02-03 00:00:00
abstract::GABAB receptors are crucial modulators of the behavioural effects of drug abuse, and agonists and positive allosteric modulators show promise as pharmacological strategies for anti-addiction therapeutics. GABAB receptors are functional heterodimers of GABAB1 and GABAB2 subunits. The predominant neuronal GABAB1 subunit...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.10.039
更新日期:2016-02-01 00:00:00
abstract::Although drug rewards and natural rewards share neural substrates, the neuronal activation patterns and mechanisms behind the interaction between cocaine and social reward are poorly understood. Here, we investigated the conditioned place preference (CPP) in social (conspecific) vs cocaine conditioning, and the expres...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.05.010
更新日期:2016-09-01 00:00:00
abstract::The lighting environment where the baby born prematurely is placed is different from that experienced in utero. As early exposure to light may affect the immature visual system we have attempted to quantify the neonatal ocular light dose. Lighting surveys performed in 7 neonatal units (NNUs) suggested that mean unit i...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/s0166-4328(05)80193-7
更新日期:1992-07-31 00:00:00
abstract::Serotonin (5-hydroxytryptamine, 5HT) plays important roles in both embryonic development as a mediator of neurogenesis and in the mature brain as a neurotransmitter. Disturbances in serotonergic transmission have been indicated in several psychiatric disorders. In the search for the biological substrates of psychiatri...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.07.008
更新日期:2005-12-07 00:00:00