Abstract：
:We have investigated the interaction between opioid peptides and dopaminergic A10 (DA-A10) neurones in the ventral tegmental area (VTA). The behavioural consequences of VTA infusion of d-Ala-Met-enkephalinamide (DALA) were analyzed. DALA elicited a dose-dependent increase in locomotor activity measured in photocell cages and the circular corridor. Observations in the open field and in a hole box revealed that DALA-induced behavioural stimulation was characterized by enhancement of locomotion, rearing, and number of hole visits, while grooming time and duration of hole visits were decreased. DALA-induced stimulation was reserved by naloxone, and was completely blocked by 6-OHDA destruction of DA-A10 terminals. d-Amphetamine-induced behavioural activation was potentiated by simultaneous VTA infusion of DALA which indicates that the behavioural response to DALA is dependent on DA-A10 neuronal activity. It is postulated that stimulation of opiate receptors exerts a presynaptic inhibition of an inhibitory input to DA-A10 neurones (eg. GABA or dendritic DA), thus releasing dopaminergic activity. In contrast to the acute effect, the d-amphetamine response was strongly attenuated 4 h, 1 and 6 days after VTA infusion of DALA, and returned to normal only at 14 days. This long-lasting modification may reflect decreased activity of opioid neurones, releasing the inhibition of DA-A10 neurones. Our findings suggest that endogenous opioid peptides may exert a modulatory influence on the dopaminergic mesocorticolimbic system.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kelley AE,Stinus L,Iversen SDdoi
10.1016/0166-4328(80)90043-1subject
Has Abstractpub_date
1980-02-01 00:00:00pages
3-24issue
1eissn
0166-4328issn
1872-7549pii
0166-4328(80)90043-1journal_volume
1pub_type
杂志文章abstract：:We have previously demonstrated that kindling of the nucleus accumbens (NAc) induced psychosis relevant behaviors only after one, but not after five, stage-5 seizures, suggesting that five stage-5 NAc-evoked seizures antagonized psychosis relevant behaviors in rats. We hypothesized that brain opioid receptors are resp...
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journal_title：Behavioural brain research
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doi：10.1016/0166-4328(90)90030-i
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(00)00354-5
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/0166-4328(94)00182-f
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.01.016
更新日期：2005-06-03 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2009.10.013
更新日期：2010-03-05 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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doi：10.1016/j.bbr.2016.07.043
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2021-02-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2019-10-17 00:00:00
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