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A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice.

Abstract：

:A crucial issue in treating opiate addiction, a chronic relapsing disorder, is to maintain a drug-free abstinent state. Prolonged abstinence associates with mood disorders, strongly contributing to relapse. In particular, substance use disorders occurring during adolescence predispose to depression later in adulthood. Using our established mouse model of opiate abstinence, we characterized emotional consequences into adulthood of morphine exposure during adolescence. Our results indicate that morphine treatment in adolescent mice has no effect on anxiety-like behaviours in adult mice, after abstinence. In contrast, morphine treatment during adolescence increases behavioural despair in adult mice. We also show that morphine exposure strain-dependently enhances sociability in adult mice. Additional research will be required to understand where and how morphine acts during brain maturation to affect emotional and social behaviours into adulthood.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Lutz PE,Reiss D,Ouagazzal AM,Kieffer BL

doi

10.1016/j.bbr.2012.12.049

subject

Has Abstract

pub_date

2013-04-15 00:00:00

pages

44-52

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(12)00839-X

journal_volume

243

pub_type

杂志文章

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