Abstract:
:Neural plasticity is a term that encompasses a vast array of changes in the nervous system in response to a wide range of environmental disturbances. The conservative manner in which nervous systems produce behavior is explored in the act of scratching the head. Whether the scratching is done with the hind leg (flamingos and axis deer) or the hand (spider monkey), it is shown that, when scratching their heads, animals follow a simple rule to avoid making multiple movements simultaneously with different parts of their bodies. Closer inspection of such a computational cost-saving scheme reveals that neural plasticity may best enhance motor performance when it occurs at higher levels of brain organization. The example of how complex social behavior, play fighting, is organized in rats shows that cortical systems can modify the contextual use of species-typical, or well-learned, behavior patterns, rather than producing new behavior patterns.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Pellis SMdoi
10.1016/j.bbr.2010.04.048subject
Has Abstractpub_date
2010-12-06 00:00:00pages
25-9issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00329-3journal_volume
214pub_type
杂志文章abstract::Methylphenidate (MPH) is the most commonly prescribed medication used to treat the symptoms associated with attention-deficit hyperactivity disorder (ADHD). The increase in ADHD diagnosis and MPH use has raised concerns regarding the long-term consequences of early exposure to psychostimulants. Animals studies indicat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.03.015
更新日期:2009-08-24 00:00:00
abstract::Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.01.019
更新日期:2019-04-19 00:00:00
abstract::Nicotine withdrawal is associated with numerous symptoms including impaired hippocampus-dependent learning. Theories of nicotine withdrawal suggest that nicotinic acetylcholine receptors (nAChRs) are hypersensitive during withdrawal, which suggests enhanced sensitivity to nicotine challenge. Research indicates that pr...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.04.053
更新日期:2013-08-01 00:00:00
abstract::Patients with psychiatric disorders of significant neurodevelopmental origin, such as schizophrenia and autism frequently experience genuine motor abnormalities, such as neurological soft signs (NSS). Previous MRI studies in patients with schizophrenia have shown that NSS are associated with abnormal cortical, thalami...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.05.048
更新日期:2015-10-01 00:00:00
abstract::Neuromedin U (NmU) is a widely distributed and multifunctional peptide in the central nervous system and the peripheral tissues. Little is know about the mechanisms of NmU on brain functions. The rodent isoform of the NmU, NmU-23, has been shown to have anxiolytic effects involved in the β-adrenergic and cholinergic n...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.11.005
更新日期:2014-02-01 00:00:00
abstract::Structural and functional brain reorganisation can occur beyond the developmental maturation period and this was recently recognised as an intrinsic property of the human central nervous system. Brain injury or altered afferent input due to environmental changes, novel experience and learning new skills are known as m...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2008.02.015
更新日期:2008-09-01 00:00:00
abstract::In a prospective study of environmental factors affecting cognitive recovery from stroke, adult male rats were reared for 3 months in a high-risk (relatively isolated, low activity, high-fat diet, high-stress) or low-risk (social, healthy diet, low-stress, physically active) environment. They then received cognitive t...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2013.05.052
更新日期:2013-09-01 00:00:00
abstract::Hypoxia-ischemia (HI)-induced perinatal encephalopathy frequently causes chronic neurological morbidities and acute mortality. Bone mesenchymal stem cell (BMSC) transplantation could potentially promote functional and anatomical recovery of ischemic tissue. In vitro hypoxic preconditioning is an effective strategy to ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.05.055
更新日期:2017-08-14 00:00:00
abstract::The feeding activity of domesticated and wild rats was studied. The rats obtained all their food by lever pressing in two-lever operant chambers. Concurrent variable interval (VI) and concurrent variable ratio (VR) schedules operated continuously for successive 4-day periods. Feeding occurred as regular, discrete meal...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(86)90050-1
更新日期:1986-01-01 00:00:00
abstract::Stress has been shown to impair decision making. However the temporal development of this phenomenon remains poorly understood. We speculated that the rapid stress induced increase in norepinephrine and the delayed increase in cortisol might exert opposing effects on decision making under risk. Therefore, three differ...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2013.04.046
更新日期:2013-08-01 00:00:00
abstract::alpha2-Adrenoceptor activation with moxonidine (alpha2-adrenergic/imidazoline receptor agonist) into the lateral parabrachial nucleus (LPBN) enhances angiotensin II/hypovolaemia-induced sodium intake and drives cell dehydrated rats to ingest hypertonic sodium solution besides water. Angiotensin II and osmotic signals ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.06.003
更新日期:2007-11-02 00:00:00
abstract::Aerobic training has a neuroprotective effect, reduces the risk of developing neurodegenerative diseases and facilitates functional recovery. The present study assesses the effect of aerobic training on cognitive functions, hippocampal BDNF/TrkB ligand receptor system expression and serum levels of BDNF and corticoste...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.111963
更新日期:2019-09-16 00:00:00
abstract::Childhood and adolescent adversity are associated with a wide range of psychiatric disorders, including an increased risk for substance abuse. Despite this, the mechanisms underlying the ability of chronic stress during adolescence to alter reward signaling remains largely unexplored. Understanding how adolescent stre...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.10.007
更新日期:2019-02-01 00:00:00
abstract::Being cautious of unfamiliar conspecifics is adaptive because sick or aggressive conspecifics may jeopardize survival and well-being. However, prolonged or excessive caution, i.e. fear related to social situations, is maladaptive and may result in social anxiety disorder. Some anxiety disorders in humans are associate...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112782
更新日期:2020-09-01 00:00:00
abstract::Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2014.05.028
更新日期:2015-01-01 00:00:00
abstract::It is well known that Alzheimer's disease (AD) is closely related to diabetes mellitus (DM), and AD is also regarded as Type 3 diabetes (T3D). However, the exact link between AD and DM is still unclear. Recently, more and more evidence has shown that glycogen synthase kinase-3β (GSK-3β) may be the potential link betwe...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.11.015
更新日期:2018-02-26 00:00:00
abstract::The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in laboratory rats. The aim of the present study was to examine the effects of chronic stress on cognitive performance. About 70% of rats exposed to 7 weeks of chronic mild stress showed a gradual reduction in consumption of a su...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.10.039
更新日期:2009-03-02 00:00:00
abstract::Cholinergic systems have been linked to cognitive processes such as attention, learning and mnemonic function. However, other neurotransmitter systems, such as the serotonergic one, which may have only minor effects on cognitive function on their own, interact with cholinergic function and their combined effects may h...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(94)00157-b
更新日期:1995-03-01 00:00:00
abstract::Cocaine-induced hyperactivity was inhibited by a single administration of naloxone (2 and 5 mg/kg, i.p.), an opioid receptor antagonist, and naloxone administered prior to and during the chronic injection of cocaine attenuated the development of both cocaine-induced reverse tolerance and conditioned place preference (...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(96)00162-3
更新日期:1997-04-01 00:00:00
abstract::Elements of the septo-preoptic basal forebrain complex, particularly the lateral and medial septum, the diagonal band of Broca, and the magnocellular preoptic area, have been linked to medial forebrain bundle (MFB) self-stimulation. This study examines the roles of these areas in MFB self-stimulation by temporarily in...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.12.005
更新日期:2007-03-12 00:00:00
abstract::Neuregulin 1 (NRG1) is an important growth factor involved in the development and plasticity of the central nervous system. Since its identification as a susceptibility gene for schizophrenia, several transgenic mouse models have been employed to elucidate the role NRG1 may play in the pathogenesis of psychiatric dise...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.05.008
更新日期:2011-10-31 00:00:00
abstract::Increasingly, research suggests a role for dopamine D1 receptors in the consolidation of extinction of both appetitive and aversive memories. However, a role for D1 receptors in extinction of memories involving drug reward has yet to be established. Here we show that post-retrieval, but not delayed, systemic administr...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.08.019
更新日期:2012-01-01 00:00:00
abstract::The chronic unpredictable mild stress (CMS) is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia in some individuals. However, the effectiveness of CMS is sometimes difficult to establish, for which unique strain sensitivities has been attribute...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00222-x
更新日期:2002-11-15 00:00:00
abstract::The effects of bilateral radiofrequency lesions in the region of the entorhinal and piriform cortex (ENT/PIR cortex) on pup-retrieving and ultrasound-elicited pup-searching behavior were investigated in ovariectomized estrogen-treated female mice, which were sensitized to pups by co-caring for a litter for 5 days toge...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80044-0
更新日期:1991-01-31 00:00:00
abstract::Value-based action selection has been suggested to be realized in the corticostriatal local circuits through competition among neural populations. In this article, we review theoretical and experimental studies that have constructed and verified this notion, and provide new perspectives on how the local-circuit select...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2016.05.017
更新日期:2016-09-15 00:00:00
abstract::Trisomy 21 or Down syndrome (DS) is the most common form of human aneuploid disorder. Increase in the copy number of human chromosome 21 genes leads to several alterations including mental retardation, heart and skeletal dysmorphologies with additional physiological defects. To better understand the genotype and pheno...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.10.023
更新日期:2011-03-01 00:00:00
abstract::Animal navigation to hidden goals (place navigation) ranks among the most intensively studied types of behaviour because it requires brain representations of environments in the form of cognitive maps, demonstrated to depend on hippocampal function. Intact function of muscarinic receptors in the brain was originally a...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.02.012
更新日期:2005-06-20 00:00:00
abstract::Autism is characterized by deficits in social interaction and social recognition. Although animal models of autism have demonstrated that model animals engage less in social interaction or attend less to conspecifics than control animals, no animal model has yet replicated the deficit in recognition of complex social ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.06.006
更新日期:2015-10-01 00:00:00
abstract::In the present study, the velocity of pointing movements towards visual targets was analyzed. In accordance with the literature, tangential velocity was found to exhibit rather smooth, single-peaked profiles. In contrast, however, the profiles of the velocity components in the Cartesian coordinates of space were consp...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(90)90030-i
更新日期:1990-08-20 00:00:00
abstract::Several clinically effective antidepressants increase the neuronal firing rate in the lateral septal nucleus (LSN), a forebrain structure that is anatomically related to medial prefrontal cortex (mPFC) regions. mPFC function is related to depression and the regulation of fear. However, unknown is whether antidepressan...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.06.007
更新日期:2018-10-01 00:00:00