Abstract：
:The radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods of food or water deprivation to achieve sufficient learning motivation resulting in stress-induced confounding effects and unwanted intra- and inter-subject variation. In a proof-of-concept approach to improve reliability and repeatability of results by refining the conventional maze methodology, we developed a voluntary, fully automated 8-arm RAM and tested its feasibility and usability using both spatial working and combined working/reference memory paradigms in ten female C57BL/6J mice. We demonstrate that experimental procedures of up to 7 days duration could be conducted without any manual animal handling and that mice up to 18 months of age showed robust spatial learning performance without any food or water restrictions being applied. Therefore, a voluntary, automated 8-arm RAM can serve to minimize variation in experimental results by reducing an animal's distress, suffering, and pain, which, in turn, contributes to the comprehensive application of 3R principles.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Mei J,Kohler J,Winter Y,Spies C,Endres M,Banneke S,Emmrich JVdoi
10.1016/j.bbr.2019.112352subject
Has Abstractpub_date
2020-03-02 00:00:00pages
112352eissn
0166-4328issn
1872-7549pii
S0166-4328(19)31345-2journal_volume
381pub_type
杂志文章abstract：:The spatial learning ability of aged male and female Sprague-Dawley rats was assessed using the Morris water maze. To determine the influence of age-related visual deficits on performance levels, retinal morphologic measures were correlated with water maze performance for each rat. Rats were first trained on the water...
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