Abstract：
:The spontaneously hypertensive rat (SHR) has been studied extensively as a purported rodent model of attention-deficit/hyperactivity disorder (ADHD). Because ADHD in humans is partially defined by marked impulsivity, SHRs, if a valid model of ADHD, ought to behave more impulsively than their normotensive parent strain, Wistar Kyoto (WKY). This prediction was evaluated in two experiments that employed an intertemporal choice procedure in which SHRs and WKYs made repeated choices between a single food pellet delivered immediately and three food pellets delivered after a delay. Four or five delays were investigated (1, 3, 6, 12 and 24s); the experiments differed in the manner in which the delays were experienced. In Experiment 1, the delay values changed after each session and were presented in ascending then descending order. SHRs chose more small/immediate reinforcers than WKYs at the longest delays during the ascending series and at nearly all delays during the descending series. In Experiment 2, the delay values remained in effect for several sessions and were presented in random order. Again, the SHRs chose more small/immediate reinforcers than the WKYs at the longest delays. Thus, in the present study, the SHRs were shown to be more impulsive than the WKYs as defined by preference for smaller, immediate reinforcers over larger, delayed ones in an intertemporal choice procedure.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Fox AT,Hand DJ,Reilly MPdoi
10.1016/j.bbr.2007.09.008subject
Has Abstractpub_date
2008-02-11 00:00:00pages
146-52issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(07)00482-2journal_volume
187pub_type
杂志文章abstract：:Synthetic cathinones share potent sympathomimetic properties with amphetamines due to their shared phenethylamine backbone. Despite recent work focused on understanding the behavioral effects of synthetic cathinones, a systematic comparison of neuropharmacology, behavior, and physiological effects with other stimulant...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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abstract：:Inadequate sleep is a major health concern of modern societies in view of the increased morbidity and mortality rates from physiological disturbances, including compromised adaptive immune responses. Many studies investigated the effect sleep restriction (SR) on the normal immune response in terms of leukocyte number ...
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abstract：:Both humans and non-humans discount the value of rewards that are delayed or uncertain, and individuals that discount delayed rewards at a relatively high rate are considered impulsive. To investigate the neural mechanisms that mediate delay discounting, the present study examined the effects of excitotoxic lesions of...
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journal_title：Behavioural brain research
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abstract：RATIONALE:Glucose enhancing effects in older adults have mostly been observed for episodic memory, but have recently been found for attentional control performance. Yet, brain activation patterns underlying these effects are still unknown. OBJECTIVE:The present study examined the acute effects of glucose ingestion on ...
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journal_title：Behavioural brain research
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更新日期：2002-09-20 00:00:00
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doi：10.1016/j.bbr.2017.05.055
更新日期：2017-08-14 00:00:00
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更新日期：2013-04-15 00:00:00
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journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2004.06.018
更新日期：2005-02-10 00:00:00
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更新日期：2016-01-01 00:00:00
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abstract：:Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...
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abstract：:The ameliorating effects of the ethyl acetate fraction from Dendropanax morbifera (EFDM) on cognitive impairment in high-fat diet (HFD)-induced diabetic mice were examined by measuring its possible pharmacological activities. Administration of EFDM (20 and 50mg/kg body weight) in HFD-induced diabetic mice significantl...
journal_title：Behavioural brain research
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abstract：:The effect of ritanserin (5-HT2 antagonist) on scopolamine (muscarinic cholinergic antagonist)-induced amnesia in Morris water maze (MWM) was investigated. Rats were divided into eight groups and bilaterally cannulated into CA1 region of the hippocampus. One week later, they received repeatedly vehicles (saline, DMSO,...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2005.11.016
更新日期：2006-04-03 00:00:00
abstract：:This is a review of our current knowledge about the role of the periaqueductal grey (PAG) in vocal control. It shows that electrical stimulation of the PAG can evoke species-specific calls with short latency and low habituation in many mammals. The vocalization-eliciting region contains neurones the activity of which ...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1994-06-30 00:00:00
abstract：:Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastri...
journal_title：Behavioural brain research
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doi：10.1016/j.bbr.2017.05.027
更新日期：2017-07-28 00:00:00
