Abstract：
:Arylsulfatase A (ASA)-deficient mice represent an animal model for the lysosomal storage disorder metachromatic leukodystrophy (MLD). Although the model has been applied in pathophysiological and therapeutic studies, the behavioural phenotype of ASA(-/-) mice is only partially characterized, and the most decisive outcome measures for therapy evaluation only emerge beyond 1 year of age. Presently, ASA(-/-) mice and ASA(+/-) control mice were studied at 6 and 12 months of age on an extensive battery including tests of neuromotor ability, exploratory behaviour, and learning and memory. Overt signs of ataxia were not observed in 6-month-old ASA(-/-) mice, but quantitative gait analysis during open-field exploration revealed that ASA(-/-) mice displayed increased hind base width and increased stride lengths for all paws. Their covert motor incoordination was evident in a correlation analysis which unveiled decreased harmonisation of concurrent gait parameters. For example, while ASA(+/-) controls demonstrated substantial convergence of front and hind base width (r=0.54), these variables actually diverged in ASA(-/-) mice (r=-0.37). Furthermore, various behavioural observations indicated emotional alterations in ASA(-/-) mice. Six-month-old ASA(-/-) mice also showed decreased response rates in scheduled operant responding. The present findings could provide relevant behavioural outcome measures for further use of this murine MLD model in preclinical studies.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Stroobants S,Leroy T,Eckhardt M,Aerts JM,Berckmans D,D'Hooge Rdoi
10.1016/j.bbr.2008.01.008subject
Has Abstractpub_date
2008-06-03 00:00:00pages
306-16issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(08)00029-6journal_volume
189pub_type
杂志文章abstract：:Central administration of angiotensin IV (Ang IV) analogues attenuates scopolamine-induced amnesia. Ang IV mediates its effects by binding to a high affinity, binding site, AT(4) receptor, that has recently been identified as insulin regulated aminopeptidase (IRAP). The purpose of this study was to examine the effect ...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2007-08-22 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2003.10.011
更新日期：2004-07-09 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1996-02-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2006-01-06 00:00:00
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journal_title：Behavioural brain research
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pub_type： 临床试验,杂志文章
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更新日期：2005-02-28 00:00:00
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journal_title：Behavioural brain research
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更新日期：2014-11-01 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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更新日期：2008-10-10 00:00:00
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journal_title：Behavioural brain research
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更新日期：2017-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-09-16 00:00:00
abstract：:Behavioral and neurobiological parallels between rabbits and humans in eyeblink classical conditioning (EBCC) make this paradigm potentially useful for preclinical and clinical trials. The known involvement of hippocampal pyramidal cells in EBCC in rabbits led us to evaluate the nootropic compound, nefiracetam. In Exp...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(97)86065-2
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