Abstract：
:Latent inhibition (LI) is a behavioural procedure in which preexposure to a stimulus not followed by reinforcement retards subsequent conditioning to this stimulus when it is paired with reinforcement. Changes in LI thus reflect greater or lesser retardation of learning which essentially implies a potentiation or an attenuation of the LI effect. LI has proved sensitive to psychotomimetic and antipsychotic treatment, which has encouraged its use to model learning and attention deficits in schizophrenia. In the present study, experiments were conducted to evaluate the effects of the psychotomimetic drug, phencyclidine (PCP, 2 mg/kg), and compare it with D-amphetamine (D-AMP, 0.33 and 1 mg/kg), on LI using a conditioned taste aversion procedure. PCP was found to potentiate LI when administered acutely prior to the conditioning trails, while no such effect was observed when administered prior to the preexposure trials. D-AMP, on the other hand, disrupted LI possibly due to a failure to induce a persistent taste aversion conditioning.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Pålsson E,Klamer D,Wass C,Archer T,Engel JA,Svensson Ldoi
10.1016/j.bbr.2004.06.018subject
Has Abstractpub_date
2005-02-10 00:00:00pages
139-46issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(04)00252-9journal_volume
157pub_type
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