当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats.

Consequences of long-term treatment with agomelatine on depressive-like behavior and neurobiological abnormalities in pinealectomized rats.

Abstract：

:Previous data have shown that the rat model of melatonin deficit can cause a number of neurobiological aberrations. The aim of the present study was to determine whether the antidepressant drug agomelatine, a MT1/MT2 melatoninergic receptor agonist/5-HT2C receptor antagonist is able to prevent some of the behavioral, biochemical and cellular abnormalities induced by pinealectomy. The injection of agomelatine (40 mg/kg, i.p. for 5 weeks)/vehicle started after pinealectomy/sham procedure in Wistar rats. Animals were tested in different behavioral tests for anxiety and depression during the period of agomelatine treatment (chronic effect) and two months later (plastic effect). The effect of agomelatine on KCl-evoked serotonin (5-HT) release from the hippocampus, the activity of the hypothalamic-pituitary-adrenal (HPA) axis and neuronal loss in pinealectomized rats were assessed. Our results showed that agomelatine not only did not prevent the disturbed emotional arousal/anxiety behavior in pinealectomized rats during the treatment but the enhanced motor activity and decreased anxiety state was still observed two months after the discontinuation of treatment. However, the drug corrected a depressive-like behavior (chronic and plastic effect), alleviated the enhanced KCl-evoked 5-HT release in the hippocampus, recovered the suppressed negative feedback inhibition of HPA axis and exerted a neuroprotection in pinealectomized rats. Our findings suggest that pinealectomy can model melancholic depression disorder while the antidepressant action of agomelatine is associated with a correction of 5-HT release in the hippocampus, dysregulated HPA system and neuroprotection in limbic structures.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Tchekalarova J,Nenchovska Z,Atanasova D,Atanasova M,Kortenska L,Stefanova M,Alova L,Lazarov N

doi

10.1016/j.bbr.2015.12.043

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

11-28

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(15)30354-5

journal_volume

302

pub_type

杂志文章

相关文献

BEHAVIOURAL BRAIN RESEARCH文献大全
  • Reversal of haloperidol induced deficits in self-stimulation by anti-Parkinsonian drugs.

    abstract：:The effects of 0.1 mg/kg dose of haloperidol on self-stimulation were assessed in rats having 3 stable self-stimulation response rates of approximately 10, 50 and 100 responses per min generated by 3 levels of current intensity. Haloperidol reduced overall response rates at all current intensities and generated extinc...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(83)90045-1

    authors： Carey RJ

    更新日期：1983-12-01 00:00:00

  • Simvastatin prevents morphine antinociceptive tolerance and withdrawal symptoms through antioxidative effect and nitric oxide pathway in mice.

    abstract：:Oxidative stress and the nitric oxide (NO) pathway are involved in the development of opioid analgesic tolerance and dependence. Simvastatin modulates NO and oxidative stress, so the present study aimed to investigate its effect on the development and expression of morphine analgesic tolerance and withdrawal signs in ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2020.113104

    authors： Houshmand G,Pourasghar M,Shiran M,Arab Firozjae A,Goudarzi M,Manouchehr F,Shirzad S,Assadpour S,Nikbakht J,Ghorbanzadeh B

    更新日期：2021-01-05 00:00:00

  • Restoring emotional stability: Cortisol effects on the neural network of cognitive emotion regulation.

    abstract：:Effective emotion regulation in stressful contexts is a key feature of mental health. Acute stress, however, impairs prefrontal top-down control, probably leading to a decline of emotion regulatory capacities. By contrast, the delayed cortisol increase in response to a stressor or after a pharmacological manipulation ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.03.049

    authors： Jentsch VL,Merz CJ,Wolf OT

    更新日期：2019-11-18 00:00:00

  • Enduring attentional deficits in rats treated with a peripheral nerve injury.

    abstract：:The present study investigated the impact of a spared nerve injury (SNI) on the daily performance of rats tested in two instrumental conditioning procedures: the progressive ratio (PR) schedule of food reinforcement to study motivation for an appetitive stimulus, and the 5-choice serial reaction time task (5-CSRTT), a...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.02.050

    authors： Higgins GA,Silenieks LB,Van Niekerk A,Desnoyer J,Patrick A,Lau W,Thevarkunnel S

    更新日期：2015-06-01 00:00:00

  • Fetal hippocampal transplants restore conditioned blocking in rats with dorsal hippocampal lesions: effect of age.

    abstract：:Previous studies have shown that conditioned blocking of taste aversion learning in 3-month-old Wistar rats depends on the hippocampal system integrity. Thus, the aim was to demonstrate that enough connectivity would develop after a graft to support the attention mechanism required for conditioned blocking. In the fir...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(97)02311-5

    authors： Gallo M,Valouskova V,Cándido A

    更新日期：1997-10-01 00:00:00

  • Dietary arginine depletion reduces depressive-like responses in male, but not female, mice.

    abstract：:Previous behavioral studies have manipulated nitric oxide (NO) production either by pharmacological inhibition of its synthetic enzyme, nitric oxide synthase (NOS), or by deletion of the genes that code for NOS. However manipulation of dietary intake of the NO precursor, L-arginine, has been understudied in regard to ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2011.04.011

    authors： Workman JL,Weber MD,Nelson RJ

    更新日期：2011-09-30 00:00:00

  • MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion.

    abstract：:Nav1.1 and Nav1.2 are the voltage-gated sodium channel alpha subunit1 and 2, encoded by the genes of SCN1A and SCN2A. Previous studies have shown that chronic cerebral hypoperfusion (CCH) could induce neuropathological and cognitive impairment and increased total Nav1.1 and Nav1.2protein levels, yet the detailed mecha...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.03.026

    authors： Hu XL,Wang XX,Zhu YM,Xuan LN,Peng LW,Liu YQ,Yang H,Yang C,Jiao L,Hang PZ,Sun LH

    更新日期：2019-07-02 00:00:00

  • D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT(2A) receptor agonist DOI.

    abstract：:Both the serotonin and glutamate systems have been implicated in the pathophysiology of schizophrenia, as well as in the mechanism of action of antipsychotic drugs. Psychedelic drugs act through the serotonin 2A receptor (5-HT2AR), and elicit a head-twitch response (HTR) in mice, which directly correlates to 5-HT2AR a...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2013.11.022

    authors： Santini MA,Balu DT,Puhl MD,Hill-Smith TE,Berg AR,Lucki I,Mikkelsen JD,Coyle JT

    更新日期：2014-02-01 00:00:00

  • Conditioned saccharin avoidance and sensitization to drugs of abuse.

    abstract：:Saccharin avoidance conditioned by drugs of abuse (CSA) has been interpreted as an expression of the appetitive, dopamine-dependent, properties of the drug. Repeated exposure to these drugs induces an increase (sensitization) of their motor stimulant properties associated with differential changes in DA transmission i...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2010.05.044

    authors： Fenu S,Cadoni C,Di Chiara G

    更新日期：2010-12-25 00:00:00

  • Influence of emotional states on inhibitory gating: animals models to clinical neurophysiology.

    abstract：:Integrating research efforts using a cross-domain approach could redefine traditional constructs used in behavioral and clinical neuroscience by demonstrating that behavior and mental processes arise not from functional isolation but from integration. Our research group has been examining the interface between cogniti...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbr.2014.05.028

    authors： Cromwell HC,Atchley RM

    更新日期：2015-01-01 00:00:00

  • Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.

    abstract：:Chronic morphine exposure induces physical dependence and tolerance. Previous studies have shown that there is a decrease in met-enkephalin levels in states of morphine physical dependence, and that increasing enkephalin during opiate physical withdrawal ameliorates the severity of the morphine withdrawal syndrome. In...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2008.08.005

    authors： Hao S,Hu J,Fink DJ

    更新日期：2009-01-30 00:00:00

  • Female fear: influence of estrus cycle on behavioral response and neuronal activation.

    abstract：:Our observation that male rat's innate fear response differed with hormonal status, as well as the higher prevalence of fear and anxiety disorders in human females led to the current investigation of the impact of phases of the estrus cycle on innate fear responding. Female rats in different phases of the cycle were e...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.01.019

    authors： Chen W,Shields J,Huang W,King JA

    更新日期：2009-07-19 00:00:00

  • Small platform stress attenuates the anxiogenic effect of diazepam withdrawal in the plus-maze test.

    abstract：:The effect of stress on the behavioural changes caused by diazepam withdrawal was studied in mice. Diazepam (2.5 mg/kg) or vehicle was injected intraperitoneally twice a day for 2 weeks. When the last vehicle or diazepam injection had been administered to the mice, 12 h later, the mice were subjected to small platform...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(98)00036-9

    authors： Pokk P,Zharkovsky A

    更新日期：1998-12-01 00:00:00

  • Celecoxib delays cognitive decline in an animal model of neurodegeneration.

    abstract：:Cyclooxygenase-2 (COX-2) is thought to play a role in the pathogenesis of various neurodegenerative disorders. However, clinical trials with COX-2 inhibitors have yielded contradictory results. In the present study we investigated whether COX-2 plays a role in the behavioral and cognitive impairments seen in olfactory...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2012.07.007

    authors： Borre Y,Lemstra S,Westphal KG,Morgan ME,Olivier B,Oosting RS

    更新日期：2012-10-01 00:00:00

  • Anxiolytic and anxiogenic effects of kindling--role of baseline anxiety and anatomical location of the kindling electrode in response to kindling of the right and left basolateral amygdala.

    abstract：:Effects of kindling of right and left basolateral amygdala (BLA) on plus maze anxiety was studied. Using a validated retest paradigm, it was possible to retest rats in the plus maze without increasing anxiety on retest. This permitted determining prekindling baseline levels of plus maze anxiety. Right BLA kindling of ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2004.10.004

    authors： Adamec R,Shallow T,Burton P

    更新日期：2005-04-15 00:00:00

  • Exploration in a dark open field: a shift from directional to positional progression and a proposed model of acquiring spatial information.

    abstract：:Exploration in a dark open field undergoes three progressive changes: (i) an initial phase of spending equal amounts of time in various zones of the arena changes to staying in the corners, and ultimately spending most of the time in one corner; (ii) travel paths are first circular and scattered all over the arena, bu...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.04.006

    authors： Avni R,Zadicario P,Eilam D

    更新日期：2006-08-10 00:00:00

  • The association between NCAM1 levels and behavioral phenotypes in children with autism spectrum disorder.

    abstract：:Autism spectrum disorders (ASDs) are neuropsychiatric disorders associated with synaptic function and plasticity. Neural cell adhesion molecule (NCAM1) dysfunction impairs synapse formation, synaptic activity and plasticity. To explore the relationship between NCAM1 and ASD, a case-control study was conducted. This re...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2018.11.012

    authors： Yang X,Zou M,Pang X,Liang S,Sun C,Wang J,Fan L,Xia W,Wu L

    更新日期：2019-02-01 00:00:00

  • The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine.

    abstract：:The selective CRF₁ (corticotropin releasing factor type 1) receptor antagonist SSR125543 has been previously shown to attenuate the long-term behavioral and electrophysiological effects produced by traumatic stress exposure in mice. Sleep disturbances are one of the most commonly reported symptoms by people with post-...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.11.006

    authors： Philbert J,Beeské S,Belzung C,Griebel G

    更新日期：2015-02-15 00:00:00

  • Studies on wakefulness-promoting effect of memantine in rats.

    abstract：:We hypothesized that memantine, an anti-dementia drug, may be useful for the treatment of excessive daytime sleepiness. The effect of memantine on excessive sleepiness after 6 h sleep deprivation was studied in comparison with that of methylphenidate, and the involvement of the dopaminergic system in the wakefulness-p...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.09.025

    authors： Ishida T,Obara Y,Kamei C

    更新日期：2010-01-20 00:00:00

  • The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome.

    abstract：:Trisomy 21 or Down syndrome (DS) is the most common form of human aneuploid disorder. Increase in the copy number of human chromosome 21 genes leads to several alterations including mental retardation, heart and skeletal dysmorphologies with additional physiological defects. To better understand the genotype and pheno...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2010.10.023

    authors： Duchon A,Pothion S,Brault V,Sharp AJ,Tybulewicz VL,Fisher EM,Herault Y

    更新日期：2011-03-01 00:00:00

  • Effects of excitotoxic thalamic intralaminar nuclei lesions on attention and working memory.

    abstract：:In rats, lesions of the thalamic intralaminar nuclei (ILn) impair measures of working memory, but it is unclear whether alterations of attention contribute to the mnemonic deficits. The present experiment tested the effects of ILn lesions on a two-lever attention task that required discrimination of visual signals and...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2005.03.018

    authors： Newman LA,Burk JA

    更新日期：2005-07-30 00:00:00

  • Sex differences in the dynamics of cue utilization and exploratory behavior.

    abstract：:The purpose of the present study was to investigate the effects of sex and estrous cycle on exploratory behavior, as well as the degree to which reliance on environmental cues changes with training. Fischer 344 rats were placed three times in an open field box that contained three objects (two identical bottles and a ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(00)00345-4

    authors： Tropp J,Markus EJ

    更新日期：2001-03-15 00:00:00

  • Anxiolytic action of urocortin 3 fragments in mice.

    abstract：:In the present experiments, the anxiolytic action of Ucn 3 fragments were studied in an elevated plus maze in mice following icv administration in an attempt to identify the biologically active center of the molecule. Ucn 3, Ucn 3 (18-38), Ucn 3 (19-27), Ucn 3 (28-38), Ucn 3 (34-38), and Ucn 3 (36-38) but not Ucn 3 (3...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2011.03.047

    authors： Telegdy G,Kádár K,Tóth G

    更新日期：2011-09-23 00:00:00

  • Stress and decision making: a few minutes make all the difference.

    abstract：:Stress has been shown to impair decision making. However the temporal development of this phenomenon remains poorly understood. We speculated that the rapid stress induced increase in norepinephrine and the delayed increase in cortisol might exert opposing effects on decision making under risk. Therefore, three differ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.bbr.2013.04.046

    authors： Pabst S,Brand M,Wolf OT

    更新日期：2013-08-01 00:00:00

  • Influence of the fat/carbohydrate component of snack food on energy intake pattern and reinforcing properties in rodents.

    abstract：:Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.02.041

    authors： Hess A,Kress S,Rakete S,Muench G,Kornhuber J,Pischetsrieder M,Müller CP

    更新日期：2019-05-17 00:00:00

  • Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period.

    abstract：:Early treatment with methylphenidate has a persistent effect on the affective (i.e., anxiety- and depressive-like) behaviors of adult rats and mice. Interestingly, age at methylphenidate exposure appears to be a critical determinant influencing the expression of affective behaviors. In the present study, we exposed ra...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2013.02.031

    authors： Crawford CA,Der-Ghazarian T,Britt CE,Varela FA,Kozanian OO

    更新日期：2013-06-01 00:00:00

  • ATP-sensitive potassium channels mediate the effects of a peripheral injection of glucose on memory storage in an inhibitory avoidance task.

    abstract：:A peripheral injection of glucose has been found to improve memory in rats, but the underlying mechanisms are unknown. One possible mechanism by which peripheral glucose might act on memory storage is by regulating ATP-sensitive potassium (K-ATP) channels. The present study investigated the effects of K-ATP channel mo...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(01)00242-x

    authors： Rashidy-Pour A

    更新日期：2001-11-29 00:00:00

  • Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.

    abstract：:Since the discovery that certain flavonoids (namely flavones) specifically recognise the central BDZ receptors, several efforts have been made to identify naturally occurring GABA(A) receptor benzodiazepine binding site ligands. Flavonoid derivatives with a flavone-like structure such as apigenin, chrysin and wogonin ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2007.12.010

    authors： Coleta M,Campos MG,Cotrim MD,Lima TC,Cunha AP

    更新日期：2008-05-16 00:00:00

  • Reward modulates neuronal activity in the hippocampus of the rat.

    abstract：:In the hippocampus of freely moving rats, neurons have been recorded that fire predominantly when the animal travels through a particular area while exploring the environment (so-called 'place cells'). This study investigates if the neuronal firing characteristics of such cells are modulated by attention, expectation ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(02)00422-9

    authors： Hölscher C,Jacob W,Mallot HA

    更新日期：2003-06-16 00:00:00

  • Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training.

    abstract：:Long-term memory of active avoidance in mice is not disturbed by administration of protein synthesis inhibitors (PSIs) when relatively high levels of training are used, whereas a detrimental effect is produced with lower levels of training. PSIs also disrupt extinction of avoidance behaviors in rodents, but it is not ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.03.031

    authors： González-Salinas S,Medina AC,Marín-Vignando V,Ruiz-López CX,Quirarte GL,Prado-Alcalá RA

    更新日期：2015-01-01 00:00:00