Abstract：
:Long-term memory of active avoidance in mice is not disturbed by administration of protein synthesis inhibitors (PSIs) when relatively high levels of training are used, whereas a detrimental effect is produced with lower levels of training. PSIs also disrupt extinction of avoidance behaviors in rodents, but it is not clear whether PSIs also affect this form of learning when the behavior to be extinguished was produced by a high level of training. Experiment 1 demonstrated that rats treated with the PSI cycloheximide (CXM) 30 min before training developed normal acquisition after training with either high or low foot-shock stimulation, but that memory consolidation was hindered only after low foot-shock training. Experiment 2 demonstrated that CXM disrupted extinction when administered before the first of a series of extinction sessions when low foot-shock intensity was used during training; in contrast, after training with a higher foot-shock, the PSI treatment only interfered transiently with extinction. These results indicate that acquisition, consolidation, and extinction of active avoidance learning produced by high aversive stimulation are not dependent on protein synthesis and that these processes are governed by mechanisms different from those underlying moderate forms of learning.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
González-Salinas S,Medina AC,Marín-Vignando V,Ruiz-López CX,Quirarte GL,Prado-Alcalá RAdoi
10.1016/j.bbr.2015.03.031subject
Has Abstractpub_date
2015-01-01 00:00:00pages
8-14eissn
0166-4328issn
1872-7549pii
S0166-4328(15)00196-5journal_volume
287pub_type
杂志文章abstract：:Like human prehensile behavior, the pigeon's ingestive pecking response is elicited by visual stimuli conveying information about the location and size of the target. This information is used to generate localized ingestive pecks whose gapes are amplitude-scaled to seed size, prior to contact. We employed high-resolut...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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