Abstract：
:Injection of the GABA(A) receptor agonist muscimol into the nucleus accumbens shell (AcbSh) elicits robust feeding in satiated rats, but has no effect on water intake. The current study was designed to examine whether intra-AcbSh muscimol injections influence the intake of ethanol solutions in rats trained to drink using a limited access paradigm. We confirmed that bilateral injections of muscimol (100 ng) into the AcbSh produce large increases in the intake of sucrose solutions and of the chow maintenance diet but found in two independent experiments that these injections potently reduce the intake of a 10% ethanol solution. Furthermore, intra-AcbSh muscimol significantly increased intake of an ethanol-sucrose mixture. These results demonstrate that activating GABA(A) receptors in the vicinity of the AcbSh can have opposite effects on the intake of different caloric substances and are consistent with the possibility that GABAergic circuits in the AcbSh may play a role in mediating voluntary ethanol intake.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Stratford TR,Wirtshafter Ddoi
10.1016/j.bbr.2010.08.032subject
Has Abstractpub_date
2011-01-20 00:00:00pages
514-8issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00591-7journal_volume
216pub_type
杂志文章abstract：:Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. We now submitted female Wistar rats to repeated cycle...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2018-09-17 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-10-15 00:00:00
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journal_title：Behavioural brain research
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更新日期：2019-03-15 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
abstract：:Severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. In Experiment 1, 60 min of continuous electrical stimulation of the perforant path sufficient to produce seizures resembling status epilepticus and loss of hilar and pyramidal cells in the hippocamp...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2002-11-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.07.036
更新日期：2009-01-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2005.01.016
更新日期：2005-06-03 00:00:00
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journal_title：Behavioural brain research
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更新日期：2002-02-01 00:00:00
abstract：:Glutamate N-methyl-d-aspartate (NMDA) receptor antagonists, such as dizocilpine (MK-801), elicit schizophrenia-like symptoms in humans and a behavioral syndrome in rodents, characterized by hyperlocomotion and stereotyped actions, which is antagonized by antipsychotic drugs. Animal models of schizophrenia have been es...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.06.014
更新日期：2010-12-25 00:00:00
abstract：:The mesolimbic dopaminergic system that projects from the ventral tegmental area (VTA) to the nucleus accumbens is critical for initiation of opioid reinforcement and reward-related effects of drugs of abuse. In the present study, the effects of reversible inactivation of VTA on acquisition and expression of morphine-...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2008.11.030
更新日期：2009-03-17 00:00:00
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pub_type： 杂志文章
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journal_title：Behavioural brain research
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更新日期：2013-05-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：2011-02-02 00:00:00
abstract：:Rabbits with lesions of the midline thalamic nuclei were compared to rabbits with sham lesions on classical eyeblink (EB) and heart rate (HR) conditioning. Separate groups of sham and lesioned animals received either 25, 50 or 100% reinforcement with a periorbital shock unconditioned stimulus. Animals with lesions sho...
journal_title：Behavioural brain research
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abstract：:The zebrafish (Danio rerio) has become an excellent tool to study mental health disorders, due to its physiological and genetic similarity to humans, ease of genetic manipulation, and feasibility of small molecule screening. Zebrafish have been shown to exhibit characteristics of addiction to drugs of abuse in non-con...
journal_title：Behavioural brain research
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更新日期：2017-09-29 00:00:00
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journal_title：Behavioural brain research
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更新日期：2015-02-01 00:00:00
abstract：:In the 6-hydroxydopamine (6-OHDA) lesioned rodent the location of the lesion produces significantly different behavioural phenotypes, responses to the dopamine precursor l-3,4-dihydroxyphenylalanine (l-DOPA) and neuropathology. Lesion extent is commonly determined by a series of motor tests, but whether any of these t...
journal_title：Behavioural brain research
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更新日期：2012-01-01 00:00:00
abstract：:Dementia is one of the major medical challenges in the industrialized countries. An increasing number of demented patients shows ischemic brain lesions. One strategy to treat dementia could be the reinforcement of the multifarious neuroprotective actions of the endogenous cell modulator adenosine. This involves the mo...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1997-02-01 00:00:00
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更新日期：2017-01-15 00:00:00
abstract：:The antidepressant agomelatine is a MT(1)/MT(2) receptor agonist and 5-HT(2C) antagonist. Its antidepressant activity is proposed to result from the synergy between these sets of receptors. Agomelatine-induced changes in the brain have been reported under basal conditions. Yet, little is known about its effects in the...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.11.045
更新日期：2011-03-17 00:00:00
abstract：:The avian hippocampal formation (HP) is considered to be homologous to the mammalian hippocampus on the basis of topography, developmental origin and its role in processing spatial memory. However, the morphological organization of the avian HP is very different from that of mammals and components similar to the subdi...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/s0166-4328(98)00087-4
更新日期：1999-02-01 00:00:00
