Abstract：
:Previous work examining animal models of cognitive flexibility have focused on tasks where animals are required to shift between cues in order to reach a food reward from among a limited set of choices. Performance by nonhuman animals on these tasks, including reversal learning, intradimensional set-shifting, and extradimensional set-shifting, are affected by pharmacological action on serotonergic, dopaminergic, and alpha-adrenergic, but not beta-adrenergic receptors. However, beta-adrenergic antagonists, such as propranolol, are widely utilized for conditions such as test anxiety. Propranolol improves performance in humans during cognitive flexibility tasks where there is a broad set of potential solutions. The current investigation utilized a digging task where the rodent must develop a novel solution in order to obtain a reward. Similar to the effects observed in humans, propranolol improved performance on this task, while not affecting performance on set-shifting tasks, as with previous animal studies. This may allow future investigation of the neurobiological mechanism by which propranolol affects context-specific anxiety, and could provide insight into the neurobiology of creativity.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Hecht PM,Will MJ,Schachtman TR,Welby LM,Beversdorf DQdoi
10.1016/j.bbr.2013.11.041subject
Has Abstractpub_date
2014-03-01 00:00:00pages
148-54eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00728-6journal_volume
260pub_type
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