当前位置： SCI文献检索 > BEHAVIOURAL BRAIN RESEARCH期刊下所有文献 > Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with spatial working memory and novelty detection.

Disruption of the direct perforant path input to the CA1 subregion of the dorsal hippocampus interferes with spatial working memory and novelty detection.

Abstract：

:Subregional analyses of the hippocampus suggest CA1-dependent memory processes rely heavily upon interactions between the CA1 subregion and entorhinal cortex. There is evidence that the direct perforant path (pp) projection to CA1 is selectively modulated by dopamine while having little to no effect on the Schaffer collateral (SC) projection to CA1. The current study takes advantage of this pharmacological dissociation to demonstrate that local infusion of the non-selective dopamine agonist, apomorphine (10, 15 microg), into the CA1 subregion of awake animals produces impairments in working memory at intermediate (5 min), but not short-term (10 s) delays within a delayed non-match-to-place task on a radial arm maze. Sustained impairments were also found in a novel context with similar object-space relationships. Infusion of apomorphine into CA1 is also shown here to produce deficits in spatial, but not non-spatial novelty detection within an object exploration paradigm. In contrast, apomorphine produces no behavioral deficits when infused into the CA3 subregion or overlying cortex. These behavioral studies are supported by previous electrophysiological data that demonstrate local infusion of the same doses of apomorphine significantly modifies evoked responses in the distal dendrites of CA1 following angular bundle stimulation, but produces no significant effects in the proximal dendritic layer following stimulation of the SC. These results support a modulatory role for dopamine in EC-CA1, but not CA3-CA1 circuitry, and suggest the possibility of a fundamental role for EC-CA1 synaptic transmission in terms of detection of spatial novelty, and intermediate-term, but not short-term spatial working memory or object-novelty detection.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Vago DR,Kesner RP

doi

10.1016/j.bbr.2008.01.002

subject

Has Abstract

pub_date

2008-06-03 00:00:00

pages

273-83

issue

2

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(08)00026-0

journal_volume

189

pub_type

杂志文章

相关文献

BEHAVIOURAL BRAIN RESEARCH文献大全
  • Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness.

    abstract：:Light can elicit both circadian and acute physiological responses in humans. In a dose response protocol men and women were exposed to illuminances ranging from 3 to 9100 lux for 6.5 h during the early biological night after they had been exposed to <3 lux for several hours. Light exerted an acute alerting response as...

    journal_title：Behavioural brain research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0166-4328(00)00236-9

    authors： Cajochen C,Zeitzer JM,Czeisler CA,Dijk DJ

    更新日期：2000-10-01 00:00:00

  • Sex differences in spatial memory using serial and search tasks.

    abstract：:The present study assessed the spatial abilities of male and female human participants using different versions of the non-navigational Corsi block-tapping test (CBT) and a search task. Males performed significantly better than females on the standard manual version of the CBT; however, the standard CBT does not allow...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2013.09.027

    authors： Shah DS,Prados J,Gamble J,De Lillo C,Gibson CL

    更新日期：2013-11-15 00:00:00

  • Neurobehavioural defects in adult mice neonatally exposed to nicotine: changes in nicotine-induced behaviour and maze learning performance.

    abstract：:Neonatal exposure to low doses of nicotine has been shown to disturb the development of low-affinity nicotinic binding sites in the cerebral cortex and to elicit a deviant behavioural response to nicotine in adult mice. In this study, 10-day-old male NMRI mice were exposed to one of three different doses of nicotine (...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(01)00207-8

    authors： Ankarberg E,Fredriksson A,Eriksson P

    更新日期：2001-09-14 00:00:00

  • Electrolytic lesions of a discrete area within the nucleus accumbens shell attenuate the long-term expression, but not early phase, of sensitization to cocaine.

    abstract：:Repeated exposure to cocaine leads to behavioral sensitization, which is the augmentation of the locomotor response to a subsequent exposure to the drug. The nucleus accumbens (NAc), a major termination site of dopaminergic neurons, is believed to be involved in behavioral sensitization and studies have demonstrated t...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2006.02.029

    authors： Brenhouse HC,Montalto S,Stellar JR

    更新日期：2006-06-30 00:00:00

  • Aging and time-of-day effects on anxiety in female Octodon degus.

    abstract：:Animal models of anxiety have usually employed nocturnal species (e.g. rats and mice), and the tests used have been almost exclusively performed during the diurnal phase (lights on). Here, for the first time, we tested anxiety in a diurnal rodent, Octodon degus, according to its age (23 versus 40 months of age) and th...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.01.001

    authors： Popović N,Baño-Otálora B,Rol MA,Caballero-Bleda M,Madrid JA,Popović M

    更新日期：2009-06-08 00:00:00

  • Valence of physical stimuli, not housing conditions, affects behaviour and frontal cortical brain activity in sheep.

    abstract：:Modulation of short-term emotions by long-term mood is little understood but relevant to understand the affective system and of importance in respect to animal welfare: a negative mood might taint experiences, whilst a positive mood might alleviate single negative events. To induce different mood states in sheep housi...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.03.036

    authors： Vögeli S,Lutz J,Wolf M,Wechsler B,Gygax L

    更新日期：2014-07-01 00:00:00

  • Phenotyping complex behaviours: assessment of circadian control and 5-choice serial reaction learning in the mouse.

    abstract：:Currently, the behavioural phenotyping of mutant strains is restricted by the paucity of tests for the cognitive capabilities of mice. Most of the paradigms at present available such as the water maze or passive avoidance are dependent upon an aversive component for conditioning and as a consequence the data can often...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(01)00300-x

    authors： Marston HM,Spratt C,Kelly JS

    更新日期：2001-11-01 00:00:00

  • H₂S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke.

    abstract：:Neuronal damage in the hippocampal formation which is more sensitive to ischemic stimulation and easily injured will cause severe learning and memory impairment. Therefore, inhibiting hippocampal neuron injuries is the main contributor for learning and memory impairment during cerebral ischemia. Hydrogen sulfide (H2S)...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.04.027

    authors： Wen X,Qi D,Sun Y,Huang X,Zhang F,Wu J,Fu Y,Ma K,Du Y,Dong H,Liu Y,Liu H,Song Y

    更新日期：2014-08-01 00:00:00

  • Coordinated movement is influenced by prenatal light experience in bobwhite quail chicks (Colinus virginianus).

    abstract：:Sensory-motor development begins early during embryogenesis and is influenced by sensory experience. Little is known about the prenatal factors that influence the development of motor coordination. Here we investigated whether and to what extent prenatal light experience can influence the development of motor coordina...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.03.039

    authors： Belnap SC,Lickliter R

    更新日期：2017-06-01 00:00:00

  • A mouse's spontaneous eating repertoire aids performance on laboratory skilled reaching tasks: A motoric example of instinctual drift with an ethological description of the withdraw movements in freely-moving and head-fixed mice.

    abstract：:Rodents display a spontaneous "order-common" pattern of food eating: they pick up food using the mouth, sit on their haunches, and transfer the food to the hands for handling/chewing. The present study examines how this pattern of behaviour influences performance on "skilled-reaching" tasks, in which mice purchase foo...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.09.044

    authors： Whishaw IQ,Faraji J,Mirza Agha B,Kuntz JR,Metz GAS,Mohajerani MH

    更新日期：2018-01-30 00:00:00

  • NMDA receptor activation and PKC but not PKA lead to the modification of the long-term potentiation in the insular cortex induced by conditioned taste aversion: differential role of kinases in metaplasticity.

    abstract：:It has been reported that training in behavioral tasks modifies the ability to induce long-term potentiation (LTP) in an N-methyl-D-aspartate receptor (NMDAR)-dependent manner. This receptor leads to calcium entry into neuronal cells, promoting the activation of protein kinases as protein kinase A (PKA) and protein ki...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2014.02.049

    authors： Rodríguez-Durán LF,Escobar ML

    更新日期：2014-06-01 00:00:00

  • The effects of zimeldine and alaproclate combined with a small dose of 5-HTP on waking and sleep stages in cats.

    abstract：:Sleep and waking stages in cats were studied 8 h following administration of zimeldine and alaproclate, in combination with saline or 5-hydroxy-1-tryptophan (5-HTP). Both drugs in combination with saline reduced rapid eye movement sleep and ponto-geniculo-occipital wave activity, and the effects were potentiated with ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(87)90031-3

    authors： Sommerfelt L,Ursin R

    更新日期：1987-04-01 00:00:00

  • Inability to acquire spatial information and deploy spatial search strategies in mice with lesions in dorsomedial striatum.

    abstract：:Dorsal striatum has been shown to contribute to spatial learning and memory, but the role of striatal subregions in this important aspect of cognitive functioning remains unclear. Moreover, the spatial-cognitive mechanisms that underlie the involvement of these regions in spatial navigation have scarcely been studied....

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.11.001

    authors： Pooters T,Gantois I,Vermaercke B,D'Hooge R

    更新日期：2016-02-01 00:00:00

  • Attenuation of auditory startle and prepulse inhibition by unexpected changes in ambient illumination through dopaminergic mechanisms.

    abstract：:We investigated the role of dopaminergic mechanisms in the attenuation of the acoustic startle response and prepulse inhibition (PPI) in rats by the introduction of unexpected changes in environment illumination. Experiment 1 showed that Dark-to-Light transitions robustly reduce startle responses and PPI. Experiment 2...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2008.08.030

    authors： Schmajuk NA,Larrauri JA,De la Casa LG,Levin ED

    更新日期：2009-02-11 00:00:00

  • Static versus dynamic effects in motor cortex and area 5: comparison during movement time.

    abstract：:We examined the directionality of static and dynamic motor effects on cell discharge recorded during arm movements in motor cortex and area 5. Movements of 8 directions were performed by rhesus monkeys in a two-dimensional space ('movement task'). Static effects were determined using a static hold task in the same wor...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(85)90071-3

    authors： Georgopoulos AP,Massey JT

    更新日期：1985-11-01 00:00:00

  • Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia.

    abstract：:Following exposure to aversive stimuli, organisms budget their behaviors by augmenting defensive responses and reducing/suppressing non-defensive behaviors. This budgeting process must be flexible to accommodate modifications in the animal's internal and/or external state that require the normal balance between defens...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2018.04.040

    authors： Leod KAM,Seas A,Wainwright ML,Mozzachiodi R

    更新日期：2018-09-03 00:00:00

  • Facultative control of avian unihemispheric sleep under the risk of predation.

    abstract：:Birds and aquatic mammals are the only taxonomic groups known to exhibit unihemispheric slow-wave sleep (USWS). In aquatic mammals, USWS permits sleep and breathing to occur concurrently in water. However, the function of avian USWS has been unclear. Our study is based on the premise that avian USWS serves a predator ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(99)00070-4

    authors： Rattenborg NC,Lima SL,Amlaner CJ

    更新日期：1999-11-15 00:00:00

  • Long-lasting effects of repeated ketamine administration in adult and adolescent rats.

    abstract：:Initiation of ketamine use often occurs in adolescence, yet little is known about long-term consequences when use begins in this developmental period. The current experiments were designed to examine the effects of repeated exposure to ketamine in adolescence on behavior in adulthood. We examined locomotor activity, a...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2019.111928

    authors： Bates MLS,Trujillo KA

    更新日期：2019-09-02 00:00:00

  • Interaction of COMT and KIBRA modulates the association between hippocampal structure and episodic memory performance in healthy young adults.

    abstract：:Genetic variations of COMT and KIBRA, which were reported to be expressed in the hippocampus, have been linked to memory function. However, their interaction on the hippocampal structure remains unknown. This study aimed to explore the interaction effects of COMT rs4680 and KIBRA rs17070145 on the hippocampal subfield...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2020.112550

    authors： Wang J,Wu S,Sun Y,Fang Y,Wu R,Lu J,Qing Z,Liang X,Wang Z,Zhang W,Chen Q,Cao P,Zhang B

    更新日期：2020-04-20 00:00:00

  • Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichment.

    abstract：:Aberrant repetitive behaviors are commonly observed in a variety of neurodevelopmental, neurological, and neuropsychiatric disorders. Little is known about the specific neurobiological mechanisms that underlie such behaviors, however, and effective treatments are lacking. Valid animal models can aid substantially in i...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2012.07.041

    authors： Muehlmann AM,Edington G,Mihalik AC,Buchwald Z,Koppuzha D,Korah M,Lewis MH

    更新日期：2012-12-01 00:00:00

  • Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

    abstract：:Much research has indicated that the mitogen-activated protein kinase (MAPK)-cAMP response element-binding protein (CREB) signal transduction pathway is involved in the pathophysiological mechanism of depression. But as to the question of which MAPKs are more relevant to stress effects, there is no definite answer. In...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2009.06.036

    authors： Li H,Zhang L,Huang Q

    更新日期：2009-12-14 00:00:00

  • Unilateral lesion in the tuberomammillary nucleus region: behavioral asymmetries and effects of histamine precursor.

    abstract：:The subnuclei of tuberomammillary nucleus are located in the posterior part of the hypothalamus adjacent to the basolateral surface of the mammillary bodies. The neurons of this nucleus innervate extensive parts of the brain with several transmitters, particularly with histamine. In fact, they represent the only sourc...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(05)80161-5

    authors： Weiler HT,Wagner U,Huston JP

    更新日期：1992-08-10 00:00:00

  • Ultrasonic vocalizations in rats anticipating circadian feeding schedules.

    abstract：:Rats readily learn to anticipate a reward signaled by an external stimulus. Anticipatory behaviors evoked by conditioned stimuli include 50 kHz ultrasonic vocalizations (USVs), a proposed behavioral correlate of positive affect and activation of midbrain dopamine pathways. Rats can also anticipate a reward, such as fo...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2015.02.003

    authors： Opiol H,Pavlovski I,Michalik M,Mistlberger RE

    更新日期：2015-05-01 00:00:00

  • Opponent-process theory and drug conditioning: an assessment for conditioned stimulant-induced movement.

    abstract：:Opponent-process theory occupies an important place in drug conditioning because it accounts for conditioned drug effects which are opposite to those induced by the drug itself. It has not been established, however, whether there is an opponent-process component to stimulant drug induced conditioned effects. In the pr...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/s0166-4328(05)80207-4

    authors： Carey RJ,Damianopoulos EN

    更新日期：1992-11-15 00:00:00

  • Functional implications of the anatomical organization of the callosal projections of visual areas V1 and V2 in the macaque monkey.

    abstract：:The efferent and afferent connections of the V1/V2 border with the contralateral hemisphere have been examined using anatomical tracers. The V1/V2 border was found to exchange connections with the contralateral V2 area as well as a restricted strip of V1 lying adjacent to the V1/V2 border. Besides these homotopic proj...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/0166-4328(88)90027-7

    authors： Kennedy H,Dehay C

    更新日期：1988-08-01 00:00:00

  • Effects of acute restraint and unpredictable chronic mild stress on brain corticotrophin releasing factor mRNA in the elevated T-maze.

    abstract：:Corticotrophin releasing factor (CRF) modulates stress/anxiety-related responses. Previous studies showed that exposure to acute restraint and unpredictable chronic mild stress (UCMS) facilitates elevated T-maze (ETM) avoidance responses, an anxiogenic-like effect. This study verified the role of CRF in the modulation...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2017.09.029

    authors： de Andrade JS,Céspedes IC,Abrão RO,da Silva JM,Ceneviva R,Ribeiro DA,Bittencourt JC,Viana MB

    更新日期：2018-01-30 00:00:00

  • Does comprehension of symbolic gestures and corresponding-in-meaning words make use of motor simulation?

    abstract：:The present study aimed at determining whether or not the comprehension of symbolic gestures, and corresponding-in-meaning words, makes use of cortical circuits involved in movement execution control. Participants were presented with videos of an actress producing meaningful or meaningless gestures, pronouncing corres...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2013.11.025

    authors： Campione GC,De Stefani E,Innocenti A,De Marco D,Gough PM,Buccino G,Gentilucci M

    更新日期：2014-02-01 00:00:00

  • Genetic dissection of nicotine-related behaviour: a review of animal studies.

    abstract：:Nicotine has a broad spectrum of behavioural effects. A considerable body of data has emerged indicating genetic factors regulate the behavioural effects of nicotine. Experimental genetic techniques have been invaluable in generating knowledge on the interrelationship of genetic factors and behavioural responsiveness ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,评审

    doi：10.1016/s0166-4328(00)00198-4

    authors： Mohammed AH

    更新日期：2000-08-01 00:00:00

  • Deficit in emotional learning in neurotrimin knockout mice.

    abstract：:Neurotrimin (Ntm) belongs to the IgLON family of cell adhesion molecules with Lsamp, Obcam and kilon that regulate the outgrowth of neurites mostly by forming heterodimers. IgLONs have been associated with psychiatric disorders, intelligence, body weight, heart disease and tumours. This study provides an initial behav...

    journal_title：Behavioural brain research

    pub_type： 杂志文章

    doi：10.1016/j.bbr.2016.09.064

    authors： Mazitov T,Bregin A,Philips MA,Innos J,Vasar E

    更新日期：2017-01-15 00:00:00

  • Functional aspects of the involvement of the hippocampus in behavior and memory functions.

    abstract：:In order to outline the involvement of the hippocampus in behavior and memory functions the results of grafting experiments in the hippocampal formation are presented in addition to former lesion and stimulation studies. Grafts of fetal hippocampal tissue were found to induce short-term beneficial effects on learning ...

    journal_title：Behavioural brain research

    pub_type： 杂志文章,评审

    doi：10.1016/0166-4328(94)00125-y

    authors： Sprick U

    更新日期：1995-01-23 00:00:00