Abstract：
:Much research has indicated that the mitogen-activated protein kinase (MAPK)-cAMP response element-binding protein (CREB) signal transduction pathway is involved in the pathophysiological mechanism of depression. But as to the question of which MAPKs are more relevant to stress effects, there is no definite answer. In the present study, 32 male Sprague-Dawley rats were divided into chronic unpredictable stress (CUS) and control groups, with 16 rats in each group. The CUS rats were exposed to 21-day chronic unpredictable stressors, and the controls were stress-free. After stress, 16 rats (8 in each group) were tested for spatial memory using Morris Water Maze, and 16 rats (8 from each group) were decapitated for detection of the three most extensively studied subgroups of MAPKs, ERK1/2, JNK and P38, and CREB in the hippocampus. The results showed that there was no statistical difference in the body weight between the two groups. The CUS rats showed impaired spatial memory in MWM. Western blot of hippocampus showed that CUS significantly decreased pCREB and pJNK levels, but there was no statistical difference between two groups in CREB, ERK1/2, pERK1/2, P38, pP38 and JNK levels. Immunohistochemistry showed that the reduced pCREB occurred in the dentate gyrus, not in the hippocampus proper. In conclusion, this study highlights that the JNK-CREB pathway, not the P38-CREB or ERK1/2-CREB pathway, in the hippocampus played an important role in the 21-day-CUS, and that the impaired spatial memory acquisition in the CUS rats can be restored to the level comparable to the pre-stressed state.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Li H,Zhang L,Huang Qdoi
10.1016/j.bbr.2009.06.036subject
Has Abstractpub_date
2009-12-14 00:00:00pages
32-7issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(09)00398-2journal_volume
205pub_type
杂志文章abstract：:Neuronal activity was recorded in the hippocampal formation, the parahippocampal gyrus and medial inferotemporal cortex of monkeys performing memory tasks. In a modified delayed matching to sample task in which 2 sequentially presented stimuli were compared on each trial, a match condition required a right panel press...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(90)90038-g
更新日期：1990-10-30 00:00:00
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更新日期：2007-12-11 00:00:00
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pub_type： 杂志文章
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更新日期：2009-12-07 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2019-01-01 00:00:00
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更新日期：2014-02-01 00:00:00
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更新日期：2015-09-15 00:00:00
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journal_title：Behavioural brain research
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pub_type： 临床试验,杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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更新日期：1995-01-23 00:00:00
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更新日期：2013-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1996-01-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2011-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1991-12-20 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2004-07-09 00:00:00
abstract：:A 5-trial inhibitory avoidance test using spontaneously hypertensive rat (SHR) pups has been used as an animal model of attention deficit hyperactivity disorder (ADHD). However, the roles of noradrenergic systems, which are involved in the pathophysiology of ADHD, have not been investigated in this model. In the prese...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2014-08-15 00:00:00
abstract：:Evidence suggests that dopamine (DA) agonists improve cognition after traumatic brain injury (TBI). Methylphenidate (MPH) is a DA agonist that blocks the dopamine transporter (DAT). Moreover, female sex hormones modulate DAT expression. Therefore, the purpose of this study was to evaluate how MPH affects behavioral pe...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.04.006
更新日期：2007-08-06 00:00:00
