Visual evoked potentials in rats selected for high or low self-stimulation.

Abstract:

:Visual evoked potentials (VEPs) were analyzed in order to distinguish between rats from genetically high (HI) and low (LO) self-stimulation lines (LC2-HI and LC2-LO). Secondary VEP components - slow secondary negative wave (SNW) and sensory afterdischarge (SAD) - which are considered to be most sensitive indices of normal and pharmacologically-induced behavioral changes, were used for the comparison. Small, albeit statistically significant enhancement of SNW and SAD was obtained in LO rats. Unlike LO animals, HI rats gained in SNW amplitude and SAD area during repeated photic stimulation. The difference being highly significant. D,L-Amphetamine (1 mg/kg, i.p.) suppressed SAD and reduced the SNW amplitude in both HI and LO animals, although the predrug difference in their values remained practically unaltered. Apomorphine (0.25, 2.75, 5.25 mg/kg i.p.) had no measurable effect on VEP parameters even though it caused a regular picture of dose-related enhancement of locomotion and stereotypy. The effect of amphetamine can, therefore, be attributed to the activation of the norepinephrinergic system. Correspondingly, VEP variance in the two lines of rats is interpreted as related to the peculiarities of norepinephrine modulation of neocortical activity.

journal_name

Behav Brain Res

authors

Myslobodsky MS,Levin D

doi

10.1016/0166-4328(84)90137-2

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

145-53

issue

2

eissn

0166-4328

issn

1872-7549

pii

0166-4328(84)90137-2

journal_volume

11

pub_type

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