Abstract:
:Visual evoked potentials (VEPs) were analyzed in order to distinguish between rats from genetically high (HI) and low (LO) self-stimulation lines (LC2-HI and LC2-LO). Secondary VEP components - slow secondary negative wave (SNW) and sensory afterdischarge (SAD) - which are considered to be most sensitive indices of normal and pharmacologically-induced behavioral changes, were used for the comparison. Small, albeit statistically significant enhancement of SNW and SAD was obtained in LO rats. Unlike LO animals, HI rats gained in SNW amplitude and SAD area during repeated photic stimulation. The difference being highly significant. D,L-Amphetamine (1 mg/kg, i.p.) suppressed SAD and reduced the SNW amplitude in both HI and LO animals, although the predrug difference in their values remained practically unaltered. Apomorphine (0.25, 2.75, 5.25 mg/kg i.p.) had no measurable effect on VEP parameters even though it caused a regular picture of dose-related enhancement of locomotion and stereotypy. The effect of amphetamine can, therefore, be attributed to the activation of the norepinephrinergic system. Correspondingly, VEP variance in the two lines of rats is interpreted as related to the peculiarities of norepinephrine modulation of neocortical activity.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Myslobodsky MS,Levin Ddoi
10.1016/0166-4328(84)90137-2subject
Has Abstractpub_date
1984-02-01 00:00:00pages
145-53issue
2eissn
0166-4328issn
1872-7549pii
0166-4328(84)90137-2journal_volume
11pub_type
杂志文章abstract::Nicotine has a broad spectrum of behavioural effects. A considerable body of data has emerged indicating genetic factors regulate the behavioural effects of nicotine. Experimental genetic techniques have been invaluable in generating knowledge on the interrelationship of genetic factors and behavioural responsiveness ...
journal_title:Behavioural brain research
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abstract::Mice altered by transgenesis or gene targeting ("knockouts") have increasingly been employed as alternative effective tools in elucidating the genetic basis of neurophysiology and behavior. Standardization of specific behavioral paradigms and phenotyping strategies will ensure that these behavioral mouse mutants offer...
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