Abstract：
:The present report provides evidence that repeated immobilization stress (RIS) induced a noradrenergic-dependent depressive-like behaviour and an augmented behavioural response to desipramine (DMI), a noradrenaline reuptake inhibitor (NRI), in the forced swimming test (FST). The present results show that RIS decreased the baseline of climbing behaviour in the FST. Whereas subchronic administration of DMI (10mg/kg, three times in a 24h period) induced a significantly higher increase in climbing behaviour on repeatedly stressed rats compared to controls. The results also show that the concomitant administration of the low dose of DMI (3mg/Kg) during the RIS fully prevented the decrease of climbing behaviour induced by RIS, without exerting behavioural effects in control rats, further supporting an augmented response to the DMI antidepressant effects in the repeatedly stressed rats. In conclusion, our data indicate that RIS not only changes the behavioural responses in the FST but also increases the antidepressant effects of DMI.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Hadweh N,Santibañez M,González MP,Forray MIdoi
10.1016/j.bbr.2010.05.037subject
Has Abstractpub_date
2010-12-25 00:00:00pages
285-9issue
2eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00411-0journal_volume
214pub_type
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