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Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.

Abstract：

:The reticulon-4 receptor, encoded by RTN4R, limits axonal sprouting and neural plasticity by inhibiting the outgrowth of neurites. Human association studies have implicated mutations in RTN4R in the development of schizophrenia, including the identification of several rare nonconservative missense mutations of RTN4R in schizophrenia patients. To investigate the effects of missense mutation of the reticulon-4 receptor on phenotypes relevant to schizophrenia, we behaviourally characterized a novel Rtn4r mutant mouse line with an amino acid substitution (R189H) in the Nogo-66 binding site. Behavioural assays included prepulse inhibition of acoustic startle, locomotor activity, social interaction and spatial cognition. When compared with wildtype littermates, Rtn4r mutant mice exhibited greater social preference, which may reflect a social-anxyolitic effect, and a mild impairment in spatial cognition. Given the mild effect of the R189H mutation of Rtn4r on behavioural phenotypes relevant to schizophrenia, our results do not support missense mutation of RTN4R as a strong risk factor in the pathogenesis of schizophrenia.

journal_name

Behav Brain Res

journal_title

Behavioural brain research

authors

Lazar NL,Singh S,Paton T,Clapcote SJ,Gondo Y,Fukumura R,Roder JC,Cain DP

doi

10.1016/j.bbr.2011.05.020

subject

Has Abstract

pub_date

2011-10-10 00:00:00

pages

73-9

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166-4328(11)00409-8

journal_volume

224

pub_type

杂志文章

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