Abstract:
:To assess the role of endogenous peptides involved in stress responsivity in the development of diet-induced obesity (DIO), selectively bred DIO and diet-resistant (DR) male were weaned onto a low fat (4.5%) chow diet at 3 weeks of age and then fed either chow or a 31% fat by energy content (high energy (HE)) diet for 9 days beginning at 4 weeks of age. Regardless of diet, DIO rats gained more weight than DR rats but did not show the selective DIO weight gain trait characteristic of older DIO rats fed HE diet. At this early age, both DR and DIO rats on HE diet ate more and had higher leptin levels but gained less body weight and had lower feed efficiency (body weight gain (g)/food intake (kcal)) than their chow-fed controls. HE diet also prevented the decline in 24h urine corticosterone levels from the third to fifth week observed in chow-fed rats. Terminally, DIO rats had lower hippocampal glucocorticoid receptor (GR) and amygdalar central nucleus corticotrophin-releasing hormone (CRH) mRNA than DR rats, regardless of their diets. Taken together with prior studies in these rats, there appears to be a critical period between 3 and 5 weeks of age when DIO and DR rats are not phenotypically different and hypothalamo-pituitary-adrenal (HPA) function is rapidly changing. The reduced expression of brain GR and CRH expression at the end of this period might contribute to the propensity of DIO rats to become obese selectively on HE diet after 5 weeks of age.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Michel C,Dunn-Meynell A,Levin BEdoi
10.1016/j.bbr.2004.03.019subject
Has Abstractpub_date
2004-10-05 00:00:00pages
511-7issue
2eissn
0166-4328issn
1872-7549pii
S0166432804001159journal_volume
154pub_type
杂志文章abstract::The present study was designed to explore the role of GSK-3β and NF-kB signaling in electric foot shock-induced stress and stress adaptation. Mice were subjected to foot shocks of 0.5mA intensity and 1s duration of 1h to produce acute stress. Animals were exposed to the same stressor for 5 days to induce stress adapta...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.014
更新日期:2016-04-01 00:00:00
abstract::Diverse cholinergic signaling mechanisms regulate the excitability of striatal principal neurons and modulate striatal-dependent behavior. These effects are mediated, in part, by action at muscarinic receptors (mAChR), subtypes of which exhibit distinct patterns of expression across striatal neuronal populations. Non-...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.03.036
更新日期:2007-07-19 00:00:00
abstract::The development of motor learning and topical motor skills has been studied during the first month of life in neurodeficient Lurcher mutant mice derived from C3H strain. The examination of motor functions was conducted using four methods when animals were consecutively placed on: a horizontal wire, a rotating cylinder...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/S0166-4328(03)00247-X
更新日期:2004-04-02 00:00:00
abstract::Previous work has established that the development of cocaine sensitization is prevented by co-administration of the non-competitive NMDA receptor antagonist MK-801 or by prior ibotenic acid lesions of the medial prefrontal cortex (PFC). The present study examined the effect of these treatments on the expression of co...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(99)00060-1
更新日期:1999-10-01 00:00:00
abstract::NC-1900, an active fragment analog of arginine vasopressin [arginine vasopressin-(4-9)], has proved to be capable of improving the spatial memory deficits and the impairments in passive avoidance test. In this study, a novel drug carrier for brain delivery, cationic bovine serum albumin conjugated pegylated nanopartic...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2006.06.001
更新日期:2006-10-02 00:00:00
abstract::Forty-six stumptail monkeys were tested for hand preference on a simple reaching task. Initial repeated reaches with the hand chosen for the first reach went unrewarded. All reaches following and including the earliest reach with the opposite hand were rewarded and were used to calculate overall hand preference for th...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(80)90009-1
更新日期:1980-12-01 00:00:00
abstract::After ablation of the motor cortex contralateral to the preferred limb, rats were forced to use this limb in grasping food out of a horizontal tube by restraining the non-preferred foreleg with a bracelet. In a right-handed rat the motor behaviour is less impaired and the recovery is better after a left hemisphere les...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(93)90032-l
更新日期:1993-09-30 00:00:00
abstract::Herein, we investigated the effect Salvia sahendica (S. sahenica) extract, an endemic plant of Iran on the improvement of learning and memory deficits in amyloid beta-(Aβ) injected rats. In order to test this hypothesis, we pretreated rats with S. sahendica 1 week prior to Aβ injection, then performed Morris water maz...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.11.026
更新日期:2013-03-15 00:00:00
abstract::Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.06.032
更新日期:2015-10-01 00:00:00
abstract::The purpose of the present study was to investigate the effects of sex and estrous cycle on exploratory behavior, as well as the degree to which reliance on environmental cues changes with training. Fischer 344 rats were placed three times in an open field box that contained three objects (two identical bottles and a ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00345-4
更新日期:2001-03-15 00:00:00
abstract::Rats with aspiration or excitotoxic (NMDA) lesions of the parahippocampal region were trained on a series of behavioral tasks which consisted of: (1) a test of spatial memory (discrete trial rewarded alternation), (2) a black-white discrimination, and (3) a test of non-spatial memory commonly used in primate models of...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(93)90011-e
更新日期:1993-05-31 00:00:00
abstract::Sensory-motor development begins early during embryogenesis and is influenced by sensory experience. Little is known about the prenatal factors that influence the development of motor coordination. Here we investigated whether and to what extent prenatal light experience can influence the development of motor coordina...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.03.039
更新日期:2017-06-01 00:00:00
abstract::In schizophrenia patients negative symptoms and cognitive impairment often persist despite treatment with second generation antipsychotics leading to reduced quality of life and psychosocial functioning. One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2012.09.034
更新日期:2013-01-15 00:00:00
abstract::In addition to their well-known genomic effects via intracellular receptors, androgens rapidly alter neuronal excitability through a nongenomic pathway. The nongenomic effect of testosterone, as the main androgen, apart from its traditional effects, was assessed in one of the fundamental centers of learning and memory...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2003.10.027
更新日期:2004-08-12 00:00:00
abstract::The rat medial prefrontal cortex has been suggested to be involved in executive functions and, more specifically, in working memory and response selection. Here, we looked for prefrontal neural correlates as rats performed a modified radial arm maze task that taxed such functions. Rats had to learn the position of fou...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.02.004
更新日期:2010-06-19 00:00:00
abstract::Alzheimer's disease (AD) is the most common form of age-related dementia (ARD). Most research directed at understanding the causes of AD is focused on the genetic-based pathology associated with the familial form of this disorder. This is important work and significant progress has been made but 85% of all AD patients...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.05.005
更新日期:2010-12-06 00:00:00
abstract::Efficient parental care is indispensable for survival of the mammalian offspring, and therefore both parents and offspring cooperate to achieve the best performance. For example, when parents transport altricial offspring, the offspring immediately respond by reducing its cry and movement in both human infants and rod...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112081
更新日期:2019-11-18 00:00:00
abstract::Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seve...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00186-3
更新日期:2001-08-01 00:00:00
abstract::Stress has been shown to impair decision making. However the temporal development of this phenomenon remains poorly understood. We speculated that the rapid stress induced increase in norepinephrine and the delayed increase in cortisol might exert opposing effects on decision making under risk. Therefore, three differ...
journal_title:Behavioural brain research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.bbr.2013.04.046
更新日期:2013-08-01 00:00:00
abstract::Substantial evidence suggests that cerebral deposition of the neurotoxic fibrillar form of amyloid precursor protein, β-amyloid (Aβ), plays a critical role in the pathogenesis of Alzheimer's disease (AD). Yet, many aspects of AD pathology including the cognitive symptoms and selective vulnerability of cortically proje...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.07.046
更新日期:2014-11-01 00:00:00
abstract::Acute stress influences learning and memory in humans and rodents, enhancing performance in some tasks while impairing it in others. Typically, subjects preferentially employ striatal-mediated stimulus-response strategies in spatial memory tasks following stress, making use of fewer hippocampal-based strategies which ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.04.027
更新日期:2018-08-01 00:00:00
abstract::In the present study, we investigated how different processing stages involved in the perceptual analysis of biological motion (BM) are reflected by modulations in event-related potentials (ERP) in order to elucidate the time course and location of neural processing of BM. Data analysis was carried out using conventio...
journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章
doi:10.1016/j.bbr.2004.06.025
更新日期:2005-02-28 00:00:00
abstract::The study concerns rats conceived, born and raised in a hypergravity environment (HG: 2 g) for 3 months using a centrifuge. They were then exposed to terrestrial gravity (1 g) and submitted to behavioural tests investigating their spontaneous locomotor activity (open-field), their posture (support surface), and their ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00085-2
更新日期:2003-02-17 00:00:00
abstract::Rodents housed with a running wheel can exhibit attenuated cocaine seeking and cocaine-induced psychomotor activation. However, the longevity of such a protection and the influence of the developmental stage during which exercise is displayed received little attention. Here, females and males C57BL/6J mice, aged 28 (a...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.04.054
更新日期:2018-09-03 00:00:00
abstract::Autism spectrum disorders (ASD) represent a class of neurodevelopmental disorders characterized by impairments in social interaction, verbal and non-verbal communication, as well as restricted interests and repetitive behavior. This latter class of symptoms often includes features such as compulsive behaviors and resi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.10.032
更新日期:2012-02-01 00:00:00
abstract::The reticulon-4 receptor, encoded by RTN4R, limits axonal sprouting and neural plasticity by inhibiting the outgrowth of neurites. Human association studies have implicated mutations in RTN4R in the development of schizophrenia, including the identification of several rare nonconservative missense mutations of RTN4R i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.05.020
更新日期:2011-10-10 00:00:00
abstract::In the primary motor cortex (M1), rhythmic activity in the gamma frequency band has been found during movement planning, onset and execution. Although the role of high-gamma oscillatory activity in M1 is well established, the contribution of low-gamma activity is still unexplored. In this study, transcranial alternati...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112170
更新日期:2019-12-30 00:00:00
abstract::Binge-like ethanol intake (BEI) is a socioeconomical problem among adolescents and increasingly affects women. BEI can leave a long-term imprint in the brain, but it is unknown if its effect on cognition and anxiety is cumulative on repeated binge-ethanol episodes. We now submitted female Wistar rats to repeated cycle...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.05.007
更新日期:2018-09-17 00:00:00
abstract::This work was aimed to study if goldfish telencephalon is involved differentially in spatial and cue learning. With this purpose, animals were assigned to two learning conditions, 'spatial constancy' and 'directly cued', and their performance was recorded before and after ablation of the telencephalon. During the pres...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(96)00014-9
更新日期:1996-09-01 00:00:00
abstract::Intracranial self-stimulation (ICSS), a special form of deep brain stimulation in which subjects self-administered electrical stimulation in brain reward areas as the lateral hypothalamus, facilitates learning and memory in a wide variety of tasks. Assuming that ICSS improves learning and memory increasing the activat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.04.025
更新日期:2013-08-01 00:00:00