Abstract:
:In addition to their well-known genomic effects via intracellular receptors, androgens rapidly alter neuronal excitability through a nongenomic pathway. The nongenomic effect of testosterone, as the main androgen, apart from its traditional effects, was assessed in one of the fundamental centers of learning and memory, the hippocampus, on long-term memory (LTM) in passive avoidance conditioning. Different doses of testosterone enanthate (T) or testosterone-BSA (T-BSA) bilaterally were injected into the CA1 region of the hippocampus 15 min before shock delivery (1 mA during 5 s) in a two-compartment passive avoidance apparatus. After 24 h, animals were tested for passive avoidance retrieval. Bilateral injection of 20 microg T or 55 microg T-BSA into the CA1 significantly decreases step-through latency. Therefore, it seems that testosterone can impair LTM in passive avoidance conditioning both via intracellular receptors and through nongenomic pathway.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Naghdi N,Asadollahi Adoi
10.1016/j.bbr.2003.10.027subject
Has Abstractpub_date
2004-08-12 00:00:00pages
1-6issue
1eissn
0166-4328issn
1872-7549pii
S0166432803003929journal_volume
153pub_type
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