Abstract：
:Diabetes mellitus is associated with disturbances of cognitive functioning. The aim of this study was to examine cognitive functioning in diabetic rats using the 'Can test', a novel spatial/object learning and memory task, without the use of aversive stimuli. Rats were trained to select a single rewarded can from seven cans. Mild water deprivation provided the motivation to obtain the reward (0.3 ml of water). After 5 days of baseline training, in which the rewarded can was marked by its surface and position in an open field, the animals were divided into two groups. Diabetes was induced in one group, by an intravenous injection of streptozotocin. Retention of baseline training was tested at 2-weekly intervals for 10 weeks. Next, two adapted versions of the task were used, with 4 days of training in each version. The rewarded can was a soft-drink can with coloured print. In a 'simple visual task' the soft-drink can was placed among six white cans, whereas in a 'complex visual task' it was placed among six soft-drink cans from different brands with distinct prints. In diabetic rats the number of correct responses was lower and number of reference and working memory errors higher than in controls in the various versions of the test. Switches between tasks and increases in task complexity accentuated the performance deficits, which may reflect an inability of diabetic rats to adapt behavioural strategies to the demands of the tasks.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Popoviç M,Biessels GJ,Isaacson RL,Gispen WHdoi
10.1016/s0166-4328(01)00186-3subject
Has Abstractpub_date
2001-08-01 00:00:00pages
201-7issue
2eissn
0166-4328issn
1872-7549pii
S0166432801001863journal_volume
122pub_type
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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