Chronic ethanol consumption induces tolerance to the spatial memory impairing effects of acute ethanol administration in rats.

Abstract:

:A large number of studies in rats have investigated the effects of acute and chronic ethanol administration on performance on many spatial learning and memory tasks. However, no study has addressed the problem of whether chronic ethanol consumption induces tolerance to acute ethanol-induced spatial memory deficits. In this study, we analyzed the behavioral effects of acute ethanol administration on spatial memory and locomotor activity in rats chronically intoxicated by ethanol. Male Sprague-Dawley rats were given as their only available liquid source a 10% (v/v) aqueous ethanol solution for 2 weeks before behavioral testing and during the 1-week behavioral testing period. They were treated intraperitoneally with 1.5 g/kg of ethanol 30 min before daily training in the Morris water maze, a spatial memory task sensitive to hippocampal damage. Our results demonstrate that learning and spatial memory of ethanol-consuming animals were not altered compared with control rats. Chronic ethanol consumption had no effect on spatial reference memory in terms of either the distance traveled to find the hidden platform during the acquisition phase of the experiment, or the time spent in the training quadrant during the retention trial. Acute ethanol administration impaired spatial memory in control rats and this impairment was reversed in chronic ethanol-consuming animals, revealing that chronic ethanol consumption did induce tolerance to the spatial memory deficits induced by acute ethanol injection, although plasma ethanol levels did not differ between the two groups. In contrast, chronic ethanol consumption did not induce tolerance to the acute ethanol-induced stimulatory locomotor activity measured in the same animals. Our results, therefore, indicate that chronic ethanol consumption induces tolerance to the cognitive impairing effects, but not to the locomotor stimulatory effects of acute ethanol administration in rats, suggesting that these two behavioral effects of ethanol do not share a common mechanism in the CNS.

journal_name

Behav Brain Res

authors

Boulouard M,Lelong V,Daoust M,Naassila M

doi

10.1016/s0166-4328(02)00134-1

subject

Has Abstract

pub_date

2002-10-17 00:00:00

pages

239-46

issue

1

eissn

0166-4328

issn

1872-7549

pii

S0166432802001341

journal_volume

136

pub_type

杂志文章
  • Mediodorsal thalamic lesions block the stress-induced inversion of serial memory retrieval pattern in mice.

    abstract::This study examines the effects of ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) on serial contextual memory retrieval in non-stress and stress conditions. Independent groups of mice learned two successive contextual serial discriminations (D1 and D2) in a four-hole board. The discriminations d...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.05.014

    authors: Chauveau F,Piérard C,Corio M,Célérier A,Christophe T,Vouimba RM,Guillou JL,Béracochéa D

    更新日期:2009-11-05 00:00:00

  • Reduction of gastrointestinal serotonin in alloxan-diabetic rats: reversal by 5-hydroxytryptophan treatment.

    abstract::A rat model of alloxan-induced diabetes was used to investigate the effect of diabetic state on serotonin (5-HT) levels in peripheral body compartments, gastrointestinal (GI) and platelet, and the metabolic response of these compartments to serotonin precursor (5-hydroxytryptophan, 5-HTP) loading in diabetes. In all s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(96)00124-6

    authors: Cićin-Sain L,Jernej B

    更新日期:1996-01-01 00:00:00

  • Differential expression of mitogen-activated protein kinase signaling pathway in the hippocampus of rats exposed to chronic unpredictable stress.

    abstract::Much research has indicated that the mitogen-activated protein kinase (MAPK)-cAMP response element-binding protein (CREB) signal transduction pathway is involved in the pathophysiological mechanism of depression. But as to the question of which MAPKs are more relevant to stress effects, there is no definite answer. In...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2009.06.036

    authors: Li H,Zhang L,Huang Q

    更新日期:2009-12-14 00:00:00

  • Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment.

    abstract::The present research studied the influence of an early chronic variable stress (CVS) paradigm - an animal model of depression - on behavioral responses to subsequent environmental challenges suggested to model anhedonia and emotional reactions such as anxiety and fear. In order to explore a potential involvement of an...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(00)00302-8

    authors: Zurita A,Martijena I,Cuadra G,Brandão ML,Molina V

    更新日期:2000-12-20 00:00:00

  • Characterization of social behaviors and oxytocinergic neurons in the S-100 beta overexpressing mouse model of Down Syndrome.

    abstract::S-100 beta, a gene triplicated in Down Syndrome (DS), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. We have been studying an animal model of DS, based on overexpression of this gene. In the current study, we report on the social behaviors of th...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(02)00373-x

    authors: Borella A,Sumangali R,Ko J,Whitaker-Azmitia PM

    更新日期:2003-05-15 00:00:00

  • The effects of early exposure to MK-801 during environmental enrichment on spatial memory, methamphetamine self-administration and cue-induced renewal in rats.

    abstract:OBJECTIVE:Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The present study was designed to examine whether early cognitive alterat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.01.032

    authors: Zhang P,Pan J,Mao Z,Xu X,Lin D,Wu B,Zhou W,Liu Y

    更新日期:2019-05-02 00:00:00

  • Helium preconditioning protects the brain against hypoxia/ischemia injury via improving the neurovascular niche in a neonatal rat model.

    abstract::This study aimed to investigate whether helium preconditioning (He-PC) is able to exert neuroprotective effects via improving focal neurovascular niche in a neonatal rat hypoxia/ischemia (HI) brain injury model. Seven day old rat pups were divided into control group, HI group and He-PC group. HI was induced by exposur...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.08.015

    authors: Li Y,Zhang P,Liu Y,Liu W,Yin N

    更新日期:2016-11-01 00:00:00

  • Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which are reduced by prior MK-801.

    abstract::Severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. In Experiment 1, 60 min of continuous electrical stimulation of the perforant path sufficient to produce seizures resembling status epilepticus and loss of hilar and pyramidal cells in the hippocamp...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(99)00107-2

    authors: Kelsey JE,Sanderson KL,Frye CA

    更新日期:2000-01-01 00:00:00

  • Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ25-35-induced neuroinflammation.

    abstract::Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.03.001

    authors: Huang N,Li Y,Zhou Y,Zhou Y,Feng F,Shi S,Ba Z,Luo Y

    更新日期:2019-06-03 00:00:00

  • Dynamic task observation: A gaze-mediated complement to traditional action observation treatment?

    abstract::Action observation elicits changes in primary motor cortex known as motor resonance, a phenomenon thought to underpin several functions, including our ability to understand and imitate others' actions. Motor resonance is modulated not only by the observer's motor expertise, but also their gaze behaviour. The aim of th...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.112351

    authors: D'Innocenzo G,Nowicky AV,Bishop DT

    更新日期:2020-02-03 00:00:00

  • Do you like Arcimboldo's? Esthetic appreciation modulates brain activity in solving perceptual ambiguity.

    abstract::Esthetic experience is a unique, affectively colored, self-transcending subject-object relationship in which cognitive processing is felt to flow differently than during everyday experiences. Notwithstanding previous multidisciplinary investigations, how esthetic experience modulates perception is still obscure. We us...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.09.041

    authors: Boccia M,Nemmi F,Tizzani E,Guariglia C,Ferlazzo F,Galati G,Giannini AM

    更新日期:2015-02-01 00:00:00

  • Differential outcomes aid the formation of categorical relationships between stimuli.

    abstract::The differential outcome effect is when learning is enhanced through the application of different outcomes to different conditions of a task. Here we explore whether one difference in learning with differential outcomes is an enhanced categorisation of objects. We demonstrate that participants learning conditional dis...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.03.036

    authors: Easton A,Child S,Lopez-Crespo G

    更新日期:2011-09-12 00:00:00

  • On the relationship between the execution, perception, and imagination of action.

    abstract::Humans can perform, perceive, and imagine voluntary movement. Numerous investigations of these abilities have employed variants of goal-directed aiming tasks because the Fitts's law equation reliably captures the mathematical relationship between movement time (MT) and accuracy requirements. The emergence of Fitts's s...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2013.09.045

    authors: Wong L,Manson GA,Tremblay L,Welsh TN

    更新日期:2013-11-15 00:00:00

  • Training-stage related neuronal plasticity in limbic thalamus and cingulate cortex during learning: a possible key to mnemonic retrieval.

    abstract::This study is part of an ongoing project concerned with the analysis of the neural substrates of discriminative avoidance learning in rabbits. Multi-unit activity was recorded in 5 anterior and lateral thalamic nuclei and in 4 layers of 2 posterior cingulate cortical areas (29c/d and 29b) during learning. The rabbits ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(05)80111-1

    authors: Gabriel M,Vogt BA,Kubota Y,Poremba A,Kang E

    更新日期:1991-12-20 00:00:00

  • Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.

    abstract::The pro-inflammatory cytokine interleukin-1 (IL-1) has been implicated in both inflammatory processes and nociceptive neurotransmission. To further investigate the role of IL-1 in different pain states, gene-disrupted mice lacking both IL-1alpha and IL-1beta genes (IL-1alphabeta (-/-)) were characterized in inflammato...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.09.024

    authors: Honore P,Wade CL,Zhong C,Harris RR,Wu C,Ghayur T,Iwakura Y,Decker MW,Faltynek C,Sullivan J,Jarvis MF

    更新日期:2006-02-28 00:00:00

  • C57BL/6 substrain differences in formalin-induced pain-like behavioral responses.

    abstract::Substantial evidence from preclinical models of pain suggests that basal and noxious nociceptive sensitivity, as well as antinociceptive responses to drugs, show significant heritability. Individual differences to these responses have been observed across species from rodents to humans. The use of closely related C57B...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112698

    authors: Ulker E,Caillaud M,Patel T,White A,Rashid D,Alqasem M,Lichtman AH,Bryant CD,Damaj MI

    更新日期:2020-07-15 00:00:00

  • EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function.

    abstract::Despite significant progress, many uncertainties remain regarding molecular and cellular mechanisms governing opiate tolerance. We report that loss of EphB2 receptor reverse signaling results in a marked acceleration of morphine tolerance in vivo. EphB2 null mice exhibited no significant difference in brain or blood m...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.09.023

    authors: Huroy S,Kanawaty A,Magomedova L,Cummins CL,George SR,van der Kooy D,Henderson JT

    更新日期:2016-03-01 00:00:00

  • Chronic exposure to mercuric chloride during gestation affects sensorimotor development and later behaviour in rats.

    abstract::The current study was performed to assess the effects of inorganic mercury (mercuric chloride - HgCl(2)) on the development of offsprings from intoxicated-mother during pregnancy. In this respect, pregnant rats were chronically treated with HgCl(2) at 50 ppm (Hg50) and 100 ppm (Hg100) in drinking water. After parturit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.06.005

    authors: Chehimi L,Roy V,Jeljeli M,Sakly M

    更新日期:2012-09-01 00:00:00

  • Prepulse inhibition of the acoustic startle reflex in pigs and its disruption by d-amphetamine.

    abstract::Prepulse inhibition (PPI) of the startle reflex is an operational measure of sensorimotor gating. The dopamine receptor agonist-mediated disruption of PPI in rats is widely used as a model of the sensorimotor gating deficiencies demonstrated in schizophrenia patients. As a possible tool for validation of a pig model o...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.04.014

    authors: Lind NM,Arnfred SM,Hemmingsen RP,Hansen AK

    更新日期:2004-12-06 00:00:00

  • Energy balance and hypothalamic self-stimulation.

    abstract::The effects of negative energy balance on self-stimulation are a matter of considerable disagreement. This disagreement undoubtedly reflects the inadequacies of the continuous reinforcement self-stimulation procedures used in this type of experimentation. The present experiment uses a new fixed-interval reinforcement ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(82)90048-1

    authors: Atrens DM,Williams MP,Brady CJ,Hunt GE

    更新日期:1982-06-01 00:00:00

  • Older adults can learn to learn new motor skills.

    abstract::Many studies have demonstrated that aging is associated with declines in skill acquisition. In the current study, we tested whether older adults could acquire general, transferable knowledge about skill learning processes. Older adult participants learned five different motor tasks. Two older adult control groups perf...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2007.05.024

    authors: Seidler RD

    更新日期:2007-10-01 00:00:00

  • Exenatide alleviates mitochondrial dysfunction and cognitive impairment in the 5×FAD mouse model of Alzheimer's disease.

    abstract::The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 rec...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2019.111932

    authors: An J,Zhou Y,Zhang M,Xie Y,Ke S,Liu L,Pan X,Chen Z

    更新日期:2019-09-16 00:00:00

  • The role of the medial olfactory pathways in olfaction: behavioral and electrophysiological data.

    abstract::The role of the olfactory inputs transmitted by the medial olfactory pathways --i.e. anterior limb of the anterior commissure and medial forebrain bundle-was studied in rats submitted either to a bilateral lesion of the anterior commissure (bAC group) or to a bilateral transection of the lateral olfactory tract follow...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(82)90017-1

    authors: Cattarelli M

    更新日期:1982-12-01 00:00:00

  • Ictal stimulus processing during spike-wave discharges in genetic epileptic rats.

    abstract::In the present experiment it was investigated whether and to what extent auditory information processing is possible during the presence of spike-wave discharges in rats. To that end, WAG/Rij rats which are an animal model for absence epilepsy, were provided with cortical electrodes for the registration of the electro...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(03)00031-7

    authors: Drinkenburg WH,Schuurmans ML,Coenen AM,Vossen JM,van Luijtelaar EL

    更新日期:2003-08-14 00:00:00

  • Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice.

    abstract::Zinc is an important element in all cells of the body, having structural, enzymatic, and regulatory functions. In some neurons, zinc is loaded into synaptic vesicles by zinc transporter 3 (ZnT3) and released into the synaptic cleft, where it can modulate neuronal function. ZnT3 knockout (KO) mice lack ZnT3 and thus la...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.12.028

    authors: Thackray SE,McAllister BB,Dyck RH

    更新日期:2017-03-15 00:00:00

  • Reward loss and the basolateral amygdala: A function in reward comparisons.

    abstract::The neural circuitry underlying behavior in reward loss situations is poorly understood. We considered two such situations: reward devaluation (from large to small rewards) and reward omission (from large rewards to no rewards). There is evidence that the central nucleus of the amygdala (CeA) plays a role in the negat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.05.036

    authors: Kawasaki K,Annicchiarico I,Glueck AC,Morón I,Papini MR

    更新日期:2017-07-28 00:00:00

  • Activation of the noradrenergic system facilitates an attentional shift in the rat.

    abstract::The noradrenergic system was pharmacologically activated with the alpha 2 receptor antagonist, idazoxan (2 mg/kg i.p.), during the acquisition of a complex appetitive task requiring a shift in attention to stimulus dimension and in response strategy. Rats first learned a fixed path of 6 successive choices in a linear ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90118-x

    authors: Devauges V,Sara SJ

    更新日期:1990-06-18 00:00:00

  • Prevention of amitriptyline-induced avoidance impairment by tacrine in mice.

    abstract::The effects of two cognition enhancers on avoidance impairment induced by the tricyclic antidepressant amitriptyline were assessed during shuttle-box avoidance acquisition and in previously trained mice of the DBA/2 strain. The nootropic agent piracetam (50, 100 or 200 mg/kg, i.p.) had slight or no effect in mice rece...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(97)00066-1

    authors: Pavone F,Battaglia M,Sansone M

    更新日期:1997-12-01 00:00:00

  • Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.

    abstract::THY-Tau22 mice constitute an animal model for tau aggregation, a hallmark in Alzheimer's disease (AD) and Tauopathies. Our previous studies have shown learning and memory deficits and changes in synaptic plasticity in the hippocampus in THY-Tau22 mice that are consistent with the learning impairments seen in AD-patien...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.12.008

    authors: Van der Jeugd A,Blum D,Raison S,Eddarkaoui S,Buée L,D'Hooge R

    更新日期:2013-04-01 00:00:00

  • Humans, but not animals, perceive the thermal grill illusion as painful.

    abstract::Simultaneous presentation of alternating innocuous warm and cold stimuli induces in most humans a painful sensation called thermal grill illusion (TGI). Here, pain is elicited although nociceptors are not activated. Upon back-translation of behavioural correlates from humans to animals, we found that neither cats nor ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.07.020

    authors: Boettger MK,Ditze G,Bär KJ,Krüdewagen EM,Schaible HG

    更新日期:2016-10-15 00:00:00