Abstract:
:Deep brain stimulation (DBS) has gained interest as a potential therapy for advanced treatment-resistant dementia. However, possible targets for DBS and the optimal stimulation parameters are not yet clear. Here, we compared the effects of DBS of the CA1 sub-region of the hippocampus, mammillothalamic tract, anterior thalamic nucleus, and entorhinal cortex in an experimental rat model of dementia. Rats with scopolamine-induced amnesia were assessed in the object location task with different DBS parameters. Moreover, anxiety-related side effects were evaluated in the elevated zero maze and open field. After sacrifice, we applied c-Fos immunohistochemistry to assess which memory-related regions were affected by DBS. When comparing all structures, DBS of the entorhinal cortex and CA1 sub-region was able to restore memory loss when a specific set of stimulation parameters was used. No anxiety-related side effects were found following DBS. The beneficial behavioral performance of CA1 DBS rats was accompanied with an activation of cells in the anterior cingulate gyrus. Therefore, we conclude that acute CA1 DBS restores memory loss possibly through improved attentional and cognitive processes in the limbic cortex.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Hescham S,Jahanshahi A,Meriaux C,Lim LW,Blokland A,Temel Ydoi
10.1016/j.bbr.2015.06.032subject
Has Abstractpub_date
2015-10-01 00:00:00pages
353-60eissn
0166-4328issn
1872-7549pii
S0166-4328(15)30058-9journal_volume
292pub_type
杂志文章abstract::Mice self-administer morphine into the lateral septum (LS), but the neuronal connections underlying this behaviour remain unknown. The present study tested whether the acquisition of intra-LS morphine self-administration depends on dopaminergic mechanisms. Mice were allowed to self-inject morphine (5 or 20ng/50nl) or ...
journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Behavioural brain research
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doi:10.1016/j.bbr.2004.11.014
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pub_type: 杂志文章
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journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2008.08.012
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
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journal_title:Behavioural brain research
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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pub_type: 临床试验,杂志文章
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