Abstract：
:Since cocaine- and amphetamine-regulated transcript peptide (CART) regulates anxiety and stress in amygdala, we hypothesized that the peptide may also process negative psychological experience like fear. During acute exposure to a cat, the rat showed freezing behavior and subsequently, profound signs of anxiety in social interaction test, and elevated serum cortisol concentration. While these behavioral effects were potentiated by the intracerebroventricular (icv) and intra-central nucleus of amygdala (intra-CeA) administration of CART peptide, they were blocked by CART antibody. On the other hand, chronic exposure for 7 days resulted in a steady reduction in freezing, increase in social interaction index and restored cortisol levels. In these rats, the behavior resembled with that of the time matched control rats suggesting habituation. However, CART peptide treatment, via the icv or intra-CeA route, chronically for 7 days, prevented habituation; significant freezing behavior and anxiety were noticed in these rats. The results suggest that CART peptide, in the framework of CeA, may process predator triggered innate fear in acute time scale, while chronic exposure might down-regulate the system and produce habituation.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Upadhya MA,Kokare DM,Subhedar NKdoi
10.1016/j.bbr.2012.12.058subject
Has Abstractpub_date
2013-04-15 00:00:00pages
129-37eissn
0166-4328issn
1872-7549pii
S0166-4328(13)00002-8journal_volume
243pub_type
杂志文章abstract：:The differential outcome effect is when learning is enhanced through the application of different outcomes to different conditions of a task. Here we explore whether one difference in learning with differential outcomes is an enhanced categorisation of objects. We demonstrate that participants learning conditional dis...
journal_title：Behavioural brain research
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