Abstract：
:Microglia, resident immune cells of the CNS are sensitive to various perturbations of the environment, such as stress exposure, and may be involved in translating these changes to behavior. Among the pathways mediating stress-related neuronal cues to microglia, the fractalkine-fractalkine receptor (CX3CR1) signaling plays a crucial role. Using mice, in which the CX3CR1 gene was deleted, we explored hormonal and behavioral responses to acute and chronic stress along with changes in hypothalamic microglia. CX3CR1-/- animals display active escape in forced swim- and tail suspension tests, exaggerated neuronal activation in the hypothalamic paraventricular nucleus and increased corticosterone release in response to restraint. Analysis of Iba1 immunostaining of hypothalamic sections revealed stress-related reduction of microglia in CX3CR1-/- mice. Because microglia also contribute to energy balance regulation, we characterized metabolic phenotype of CX3CR1-/- mice. Comparison of respiratory exchange ratio did not show genotype effect on fuel preference, however, the energy expenditure was increased in CX3CR1-/- mice, which may be related to their active coping behavior. Microglia and fractalkine signaling has been repeatedly shown to be involved chronic stress-induced depressive state. CX3CR1-/- mice did not become anhedonic in the "two hit" chronic stress paradigm, confirming resistance of these animals to chronic stress-induced mood alterations. However, there was no difference in stress hormone levels, open field performance and hypothalamic microglia distribution between the genotypes. These results highlight differential involvement of microglia fractalkine signaling in controlling/integrating hormonal-, metabolic and behavioral responses to acute and chronic stress challenges.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Winkler Z,Kuti D,Ferenczi S,Gulyás K,Polyák Á,Kovács KJdoi
10.1016/j.bbr.2017.07.023subject
Has Abstractpub_date
2017-09-15 00:00:00pages
119-128eissn
0166-4328issn
1872-7549pii
S0166-4328(17)30565-Xjournal_volume
334pub_type
杂志文章abstract：:In order to automate a simultaneous visual discrimination system, a Sutherland jumping-stand box was modified by adding two lateral alleys which connect the feeder compartment with the starting box. By means of a digital interface, this modified box was connected to an Apple IIe PC. A group of rats (n = 8) was trained...
journal_title：Behavioural brain research
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abstract：:Recent evidence shows that early life stress (ELS) is associated with altered resting-state functional connectivity (RSFC) between amygdala and the prefrontal cortex, as well as with maladaptive emotion regulation strategies and negative mood. However, the relation between ELS and maladaptive emotion regulation is not...
journal_title：Behavioural brain research
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更新日期：2018-01-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-03-01 00:00:00
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更新日期：1996-01-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2008-12-16 00:00:00
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2008-01-10 00:00:00
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更新日期：2006-08-10 00:00:00
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pub_type： 杂志文章
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更新日期：2009-01-03 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
abstract：:The rabbit classical nictitating membrane/eyeblink conditioning preparation has proven highly valuable for delineating neural structures and systems involved in associative learning. Research conducted over the last 20 years has revealed that the essential neural circuitry for acquisition and performance of this simpl...
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更新日期：2000-06-01 00:00:00
