Abstract：
:Isolation rearing is a developmentally specific non-pharmacological manipulation in rats that produces a deficit in sensorimotor gating, as measured by prepulse inhibition (PPI) of the startle reflex. Previous research has demonstrated that the isolation rearing effect on PPI is sensitive to several factors, including the time of testing with respect to length of isolation, prepulse intensities used, strain of rats, and type of housing environment. This study tested whether handling is another factor that interacts with the isolation-rearing paradigm in PPI. Rats were housed either in the social (three rats per cage) or isolate (one rat per cage) conditions and were handled either 1-2 times per week (minimal handling) or on a daily basis (daily handling). All rats were then tested at 8 and 10 weeks post-weaning. There was an interaction between housing and handling. In the minimal handling condition, isolation rearing produced a deficit in PPI. This effect was absent, however, in the daily handling condition. Thus, regular handling of rats may interfere with the observation of the isolation rearing effect on PPI and should be carefully controlled in studies using this animal model of PPI deficits.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Krebs-Thomson K,Giracello D,Solis A,Geyer MAdoi
10.1016/s0166-4328(00)00374-0subject
Has Abstractpub_date
2001-05-01 00:00:00pages
221-4issue
2eissn
0166-4328issn
1872-7549pii
S0166432800003740journal_volume
120pub_type
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