Abstract：
:The brain might be exposed to irradiation under a variety of situations, including clinical treatments, nuclear accidents, dirty bomb scenarios, and military and space missions. Correctly recalling tasks learned prior to irradiation is important but little is known about post-learning effects of irradiation. It is not clear whether exposure to X-ray irradiation during memory consolidation, a few hours following training, is associated with altered contextual fear conditioning 24h after irradiation and which brain region(s) might be involved in these effects. Brain immunoreactivity patterns of the immediately early gene c-Fos, a marker of cellular activity was used to determine which brain areas might be altered in post-training irradiation memory retention tasks. In this study, we show that post-training gamma irradiation exposure (1 Gy) enhanced contextual fear memory 24h later and is associated with reduced cellular activation in the infralimbic cortex. Reduced GABA-ergic neurotransmission in parvalbumin-positive cells in the infralimbic cortex might play a role in this post-training radiation-enhanced contextual fear memory.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Kugelman T,Zuloaga DG,Weber S,Raber Jdoi
10.1016/j.bbr.2015.10.050subject
Has Abstractpub_date
2016-02-01 00:00:00pages
1-11issue
Pt Beissn
0166-4328issn
1872-7549pii
S0166-4328(15)30262-Xjournal_volume
298pub_type
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