Abstract：
:Metabolic consequences of morphine dependence and withdrawal intervention have not been well explored. In the present study, the metabolic changes in brain hippocampus, nucleus accumbens (NAc), prefrontal cortex (PFC) and striatum of rats with morphine dependence and withdrawal intervention were explored by using ¹H nuclear magnetic resonance coupled with principal component analysis, partial least squares and orthogonal signal correction analysis. We found that the concentrations of neurotransmitters including glutamate, glutamine and gamma-aminobutyric acid changed differentially in hippocampus, NAc, PFC and striatum after repeated morphine treatment. Significant changes were also found in a number of cerebral metabolites including N-acetyl aspartate (NAA), lactic acid, creatine, myo-inositol and taurine. These findings indicate the profound disturbances of energy metabolism, amino acid metabolism and neurotransmitters caused by chronic morphine treatment. Interestingly, morphine-induced changes in lactic acid, creatine and NAA were clearly reversed by intervention of methadone or clonidine. Our study provides a comprehensive understanding of the metabolic alteration associated with morphine addiction and withdrawal therapy, which may help to develop new pharmacotherapies.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Hu Z,Deng Y,Hu C,Deng P,Bu Q,Yan G,Zhou J,Shao X,Zhao J,Li Y,Zhu R,Xu Y,Zhao Y,Cen Xdoi
10.1016/j.bbr.2012.02.026subject
Has Abstractpub_date
2012-05-16 00:00:00pages
11-9issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(12)00136-2journal_volume
231pub_type
杂志文章abstract：:Cholinergic systems have been linked to cognitive processes such as attention, learning and mnemonic function. However, other neurotransmitter systems, such as the serotonergic one, which may have only minor effects on cognitive function on their own, interact with cholinergic function and their combined effects may h...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/0166-4328(94)00157-b
更新日期：1995-03-01 00:00:00
abstract：:Behavioural activation repeatedly induced by a stimulant in rodents can persist in the absence of the drug if the animals are tested in the context where the drug was previously given, a phenomenon often explained in terms of Pavlovian conditioning. The aim of this study was to verify whether the amplitude of the puta...
journal_title：Behavioural brain research
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doi：10.1016/s0166-4328(03)00106-2
更新日期：2003-10-17 00:00:00
abstract：:When making choices under uncertainty, people usually consider both the risks and benefits of each option. Previous studies have found that weighing of risks and benefits during decision-making involves a complex neural network that includes the dorsolateral prefrontal cortex (DLPFC), but the causal effect of this net...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：Behavioural brain research
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更新日期：2003-11-30 00:00:00
abstract：:Motor cortex stimulation oriented by functional cortical mapping is used mainly for treating otherwise intractable neurological disorders, however, its mechanism of action remains elusive. Herein, we present a new method for functional mapping of the rat motor cortex using non-invasive transdural electrical stimulatio...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2009-08-24 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2010-02-11 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1993-04-30 00:00:00
abstract：:Physiological effects of different types, of continuous and interval aerobic training, have been largely described and studied in the adult man. It was previously indicated that interval training plays an important role in maximizing both peripheral muscle and central cardiorespiratory adaptations, permitting signific...
journal_title：Behavioural brain research
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更新日期：2017-08-14 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.07.037
更新日期：2017-09-29 00:00:00
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更新日期：1986-06-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2005-04-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2016.04.037
更新日期：2016-07-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2021-02-26 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2020-01-27 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.01.053
更新日期：2017-05-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.12.033
更新日期：2011-06-01 00:00:00
abstract：:Repeated exposure to cocaine leads to behavioral sensitization, which is the augmentation of the locomotor response to a subsequent exposure to the drug. The nucleus accumbens (NAc), a major termination site of dopaminergic neurons, is believed to be involved in behavioral sensitization and studies have demonstrated t...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.02.029
更新日期：2006-06-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.08.010
更新日期：2017-09-29 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2000-09-01 00:00:00
abstract：:S-100 beta, a gene triplicated in Down Syndrome (DS), is thought to play a role in development of the brain in general, and in the serotonergic neuronal system in particular. We have been studying an animal model of DS, based on overexpression of this gene. In the current study, we report on the social behaviors of th...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2003-05-15 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/0166-4328(88)90022-8
更新日期：1988-12-01 00:00:00
abstract：:The behavioral consequences of uncontrollable stress that are collectively called learned helplessness (LH) are mediated in part by increased levels of serotonin (5-HT) activity in the dorsal raphe nucleus (DRN) and it's projection regions. Recently, corticotropin-releasing hormone (CRH) within the DRN has been implic...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2003-12-17 00:00:00
abstract：:Strategic processing allows for value-based preferential encoding of information. Event-related spectral perturbations can provide insights into neural processes linked to the different aspects of strategic processing. This study examined theta and alpha band power differences linked to processing of high- versus low-...
journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-07-23 00:00:00
abstract：:In the present study, 40 Sprague-Dawley rats were divided into forced swim stress group and controls, with 20 rats in each group (10 for behavioral tests, 10 for protein detection). The forced swim stress group received swim stress for 14 consecutive days, and the controls were stress-free. After stress, 20 rats were ...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2006.08.035
更新日期：2006-12-15 00:00:00
abstract：:Hand shaping is an important part of many skilled hand movements and includes a number of hand shapes prominent amongst which is collection. In collection, the hand is held with the digits lightly closed and flexed. It occurs when the hand is at rest and it occurs as the hand is transported to a target in behaviors su...
journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2010.04.052
更新日期：2010-12-06 00:00:00
abstract：:The rabbit classical nictitating membrane/eyeblink conditioning preparation has proven highly valuable for delineating neural structures and systems involved in associative learning. Research conducted over the last 20 years has revealed that the essential neural circuitry for acquisition and performance of this simpl...
journal_title：Behavioural brain research
pub_type： 杂志文章,评审
doi：10.1016/s0166-4328(99)00181-3
更新日期：2000-06-01 00:00:00
