Abstract:
:Neglect in human and non-human primates has been demonstrated following unilateral lesions of both posterior parietal and prefrontal areas. While it has now been well established that a unilateral lesion of the rodent analog of dorsolateral prefrontal cortex, medial agranular cortex (AGm), results in neglect, the effects of unilateral damage restricted to rodent posterior parietal cortex (PPC) have not been examined in detail. The current study assessed rats with unilateral lesions of PPC or AGm on their ability to orient to unilateral and bilateral stimulation. Since it has been proposed in both the primate and rodent literatures that frontal areas may be responsible for the perception of near space while parietal areas may be responsible for far space, stimuli were presented at two different distances. Lesions of PPC and AGm resulted in severe neglect relative to control operates, with both PPC and AGm operates manifesting severe hemi-inattention and allesthesia relative to control operates. After behavioral recovery from neglect there was no evidence of extinction to bilateral simultaneous stimulation. While neglect to visual stimuli predominated in unilateral PPC operates, unilateral AGm operates had severe neglect in all modalities. In addition, while both left and right PPC operates showed contralesional neglect, AGm operates demonstrated the lateralized differences in neglect reported in previous studies. All groups demonstrated an approximately equivalent level of neglect to stimuli presented at the two different distances, and thus failed to support the suggestion of a peripersonal-extrapersonal dichotomy between frontal and parietal areas in rodents.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
King VR,Corwin JVdoi
10.1016/0166-4328(93)90070-7subject
Has Abstractpub_date
1993-04-30 00:00:00pages
117-31issue
2eissn
0166-4328issn
1872-7549pii
0166-4328(93)90070-7journal_volume
54pub_type
杂志文章abstract::A rat model of novelty-seeking phenotype predicts vulnerability to nicotine relapse where locomotor reactivity to novelty is used to rank high (HR) versus low (LR) responders. Present study investigates implication of cannabinoid receptor 1 (CB1R) in the basolateral (BLA) and the central (CeA) nuclei of amygdala in be...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.11.015
更新日期:2012-03-01 00:00:00
abstract::Unilateral microinjections of bethanechol chloride into the CA3 subfield of the dorsal hippocampus in unrestrained rats produced a seizure-related type behavioural and disseminated brain damage syndrome. Injection of bethanechol in the dose of 50 micrograms resulted in locomotor activation, mouth movements, teeth chat...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90026-8
更新日期:1983-03-01 00:00:00
abstract::Cognitive-behavioral therapy (CBT), a first-line treatment for pediatric anxiety disorders, is based on principles of threat learning and extinction. However, CBT does not work sufficiently for up to 40% of clinically anxious youth. The neural and behavioral correlates of conditioned inhibition might provide promising...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112994
更新日期:2021-02-05 00:00:00
abstract::Functional recovery after an experimental stroke can be assessed by multiple behavioral tests, however, there is no consensus about which test to use in long-term stroke recovery studies or whether the tests are affected by stroke surgery, post-operative care or behavioral compensation due to repeated testing. This re...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.07.039
更新日期:2018-10-15 00:00:00
abstract::We postulated that gradual muscle relaxation during motor learning would dynamically change activity in the primary motor cortex (M1) and modify short-interval intracortical inhibition (SICI). Thus, we compared changes in M1 excitability both pre and post motor learning during gradual muscle relaxation. Thirteen healt...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2015.09.001
更新日期:2016-01-01 00:00:00
abstract::Deep brain stimulation (DBS) has been shown to be effective for relief of Parkinson's disease, depression and obsessive-compulsive disorder in humans, but the effect of DBS on psychosis is largely unknown. In previous studies, we showed that inactivation of the medial septum or nucleus accumbens normalized the hyperac...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.03.010
更新日期:2014-06-01 00:00:00
abstract::Nerve growth factor (NGF) has potent biological activities such as preventing neuronal death, promoting neurite outgrowth, supporting synapse formation, and enhancing memory function. NGF and NGF-like molecules can potentially be used to treat neurodegenerative disorders, such as dementia. This study investigated the ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.09.008
更新日期:2011-01-20 00:00:00
abstract::In late-stage embryos of domestic fowl, exposure of the right eye to light entering through the shell induces asymmetry of the thalamofugal visual pathway, together with differences in performance according to whether the right or left eye (RE, LE) is in use (Behav. Brain Res. 38 (1990) 211). Nevertheless, at least so...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.04.016
更新日期:2004-11-05 00:00:00
abstract::Accumulating evidence points to a genetic contribution to explain inter-individual vulnerability to sleep deprivation. A functional polymorphism in the BDNF gene, which causes a valine (Val) to methionine (Met) amino acid substitution at Codon 66, has been associated with cognitive impairment, particularly in populati...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2017.09.025
更新日期:2018-02-15 00:00:00
abstract::To determine whether local neurons mediated the locomotor effects of electrical stimulation of the lateral hypothalamus, kainic acid injections (0.5-1.25 micrograms), intended to destroy neural somata as opposed to fibers of passage, were made unilaterally in the tuberal-posterior hypothalamus of 22 rats. The area of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(05)80096-8
更新日期:1991-12-13 00:00:00
abstract::This study was aimed at determining whether granule cell degeneration induced by intragyral injections of a neutral fluid (0.9% NaCl with 0.6% glucose, pH 7.0, 2 sites per hippocampus, 2 microliters/site, 1 microliter/min) produced behavioural deficits in rats which, 2 weeks prior to the injections had received either...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90088-4
更新日期:1994-08-31 00:00:00
abstract::Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates. The current study investigated whether adolescent cocaine exposure activated neurons in areas of hamster forebrain implicated in aggressive behavior by examining the expre...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.11.027
更新日期:2005-04-30 00:00:00
abstract::Diverse cholinergic signaling mechanisms regulate the excitability of striatal principal neurons and modulate striatal-dependent behavior. These effects are mediated, in part, by action at muscarinic receptors (mAChR), subtypes of which exhibit distinct patterns of expression across striatal neuronal populations. Non-...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.03.036
更新日期:2007-07-19 00:00:00
abstract::Expression levels of neuropeptide Y (NPY) are changed in schizophrenia patients. However, the direction of changes to NPY expression and the mechanisms behind NPY's impact on the development of the illness is not understood in detail. Here we investigated whether alterations in Y2 activity may be involved in the devel...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.10.029
更新日期:2010-03-05 00:00:00
abstract::Testing of cognitive functions in rodent disease models constitutes a substantial sector of behavioral neuroscience. It is most often needed in phenotyping genetically modified new rodent (usually mouse) lines or in preclinical testing of cognitive effects of new CNS drugs. This review concerns present pitfalls and fu...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2017.05.040
更新日期:2018-10-15 00:00:00
abstract::Aging has diverse effects on different behaviors and underlying neural systems. This study utilized fear conditioning to determine if aged mice have deficits in the acquisition and/or retention of memories for contextual or cued fear conditioning, and to determine if galantamine, an acetylcholinesterase (AChE) inhibit...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.06.040
更新日期:2005-12-07 00:00:00
abstract::The behavioral consequences of uncontrollable stress that are collectively called learned helplessness (LH) are mediated in part by increased levels of serotonin (5-HT) activity in the dorsal raphe nucleus (DRN) and it's projection regions. Recently, corticotropin-releasing hormone (CRH) within the DRN has been implic...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(03)00133-5
更新日期:2003-12-17 00:00:00
abstract::Despite the apparent age-related decline in perceptual-motor performance, recent studies suggest that the elderly people can improve their reaction time when relevant sensory information are available. However, little is known about which sensory information may improve motor behaviour itself. Using a synchronization ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.08.043
更新日期:2014-12-15 00:00:00
abstract::Individuals are increasingly exposed to light at night. Exposure to constant light (LL) disrupts circadian rhythms of locomotor activity, body temperature, hormones, and the sleep-wake cycle in animals. Other behavioural responses to LL have been reported, but are inconsistent. The present experiment sought to determi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.07.001
更新日期:2009-12-28 00:00:00
abstract::This experiment compared the shortcut choices of able-bodied teenagers with those of physically disabled teenagers who had varying histories of mobility impairment. In a computer-simulated kite-shaped maze, participants were allowed to explore three arms that connected four rooms. Subsequently they were offered a choi...
journal_title:Behavioural brain research
pub_type: 临床试验,杂志文章
doi:10.1016/s0166-4328(02)00097-9
更新日期:2002-10-17 00:00:00
abstract::This study was undertaken to investigate, in guinea pigs, the effects of pre- and early postnatal social stress on the functioning of hormonal-, autonomic-, behavioral-, and limbic-brain systems. Dams had either lived in groups with a constant composition (i.e. stable social environment) or in groups with changing com...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(03)00077-9
更新日期:2003-09-15 00:00:00
abstract::Prepulse inhibition (PPI) of the startle reflex is an operational measure of sensorimotor gating. The dopamine receptor agonist-mediated disruption of PPI in rats is widely used as a model of the sensorimotor gating deficiencies demonstrated in schizophrenia patients. As a possible tool for validation of a pig model o...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.04.014
更新日期:2004-12-06 00:00:00
abstract::Serotonin, acting through a cAMP-signaling pathway, delayed habituation to criterion of the leech's swim response to touch. This delay was reversed by crushing the connective between serotonin-exposed and serotonin-naive ganglia, and correlated with an increase in spontaneous impulse activity in this connective. We su...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.05.008
更新日期:2007-08-22 00:00:00
abstract::The relevance of adult neurogenesis in hippocampal function is well documented, as is the potential impact stress has on the adult neurogenic niche. Adult born neurons are generated from neural precursors in the dentate gyrus (DG), although the point in postnatal development that these cell precursors originate is not...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.11.013
更新日期:2015-02-15 00:00:00
abstract::Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisi...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.111947
更新日期:2019-09-16 00:00:00
abstract::Atypical antipsychotic drugs (AAPDs) induce hyperphagia and body weight gain as a deleterious side effect. However, the mechanism whereby these drugs affect the neuronal pathways regulating energy balance has yet to be fully elucidated. The present study was conducted to investigate the respective and interaction effe...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2009.09.032
更新日期:2010-02-11 00:00:00
abstract::Axonal branching patterns of physiologically identified cerebellar nucleus neurones and rubrospinal neurones were investigated in the cat with intra-axonal injection of horseradish peroxidase and 3-dimensional reconstruction on serial sections. Axons of dentate and interpositus neurones projected to the VL nucleus of ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(88)90076-9
更新日期:1988-04-01 00:00:00
abstract::Previous work found that single-session focused attention meditation (FAM) enhanced motor sequence learning through increased cognitive control as a mechanistic action, although electrophysiological correlates of sequence learning performance following FAM were not investigated. We measured the persistent frontal N2 e...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112536
更新日期:2020-04-20 00:00:00
abstract::Neonatal mice received subcutaneous injections of either antibody against murine NGF raised in goat (3 mg, injection volume 50 microliters) or preimmune serum on postnatal days 2, 4, 6, 8, 10, and 12. They were tested on postnatal days 15-16 or 20-21 for learning and 24-h retention of a passive avoidance step-through ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(95)00234-0
更新日期:1996-08-01 00:00:00
abstract::Repeated administration of methamphetamine (mAMPH) to rodents in a single-day "binge" regimen damages forebrain monoaminergic nerve terminals and produces subsequent cognitive deficits. Here we investigate performance on a social odor-based task, demonstrating enduring mAMPH-induced deficits in recognition memory. Thr...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.08.022
更新日期:2011-01-01 00:00:00