Abstract：
:Deep brain stimulation (DBS) has been shown to be effective for relief of Parkinson's disease, depression and obsessive-compulsive disorder in humans, but the effect of DBS on psychosis is largely unknown. In previous studies, we showed that inactivation of the medial septum or nucleus accumbens normalized the hyperactive and psychosis-related behaviors induced by psychoactive drugs. We hypothesized that DBS of the medial septum or nucleus accumbens normalizes the ketamine-induced abnormal behaviors and brain activity in freely moving rats. Male Long-Evans rats were subcutaneously injected with ketamine (3 mg/kg) alone, or given ketamine and DBS, or injected with saline alone. Subcutaneous injection of ketamine resulted in loss of gating of hippocampal auditory evoked potentials (AEPs), deficit in prepulse inhibition (PPI) and hyperlocomotion, accompanied by increased hippocampal gamma oscillations of 70-100 Hz. Continuous 130-Hz stimulation of the nucleus accumbens, or 100-Hz burst stimulation of the medial septum (1s on and 5s off) significantly attenuated ketamine-induced PPI deficit and hyperlocomotion. Medial septal stimulation also prevented the loss of gating of hippocampal AEPs and the increase in hippocampal gamma waves induced by ketamine. Neither septal or accumbens DBS alone without ketamine injection affected spontaneous locomotion or PPI. The results suggest that DBS of the medial septum or nucleus accumbens may be an effective method to alleviate psychiatric symptoms of schizophrenia. The effect of medial septal DBS in suppressing both hippocampal gamma oscillations and abnormal behaviors induced by ketamine suggests that hippocampal gamma oscillations are a correlate of disrupted behaviors.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ma J,Leung LSdoi
10.1016/j.bbr.2014.03.010subject
Has Abstractpub_date
2014-06-01 00:00:00pages
174-82eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00155-7journal_volume
266pub_type
杂志文章abstract：:The α9α10-subtype of nicotinic acetylcholine receptor (nAChR) has recently garnered interest in biomedicine and is being pursued as an analgesic target. However, the receptor exhibits diverse tissue distribution, the function of which is known to varying degrees, and targeting this receptor for clinical treatments wit...
journal_title：Behavioural brain research
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journal_title：Behavioural brain research
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pub_type： 杂志文章
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journal_title：Behavioural brain research
pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2007-06-18 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2019-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bbr.2006.01.023
更新日期：2006-06-03 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2017.09.029
更新日期：2018-01-30 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2007.07.041
更新日期：2008-01-10 00:00:00
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pub_type： 杂志文章
doi：10.1016/0166-4328(83)90019-0
更新日期：1983-03-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2009.05.032
更新日期：2009-12-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2011.04.011
更新日期：2011-09-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bbr.2010.02.001
更新日期：2010-06-26 00:00:00
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pub_type： 杂志文章
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更新日期：2010-12-06 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2004-12-06 00:00:00
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journal_title：Behavioural brain research
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更新日期：2015-04-01 00:00:00
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更新日期：2020-09-15 00:00:00
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pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
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更新日期：2016-04-01 00:00:00
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journal_title：Behavioural brain research
pub_type： 杂志文章
doi：10.1016/j.bbr.2014.07.026
更新日期：2014-10-15 00:00:00
