Abstract:
:The effect of intraseptal injections of lidocaine before a first or a second session in the elevated plus-maze, in a test-retest paradigm, was investigated. In addition to gross session analyses, a minute-by-minute analysis of the sessions was used to evaluate both anxiety and memory. Lidocaine injections before the test session produced increases in the frequency of entries, time spent and distance run in the open arms without affecting activity occurring in the closed arms. During the retest session, saline- and lidocaine-treated rats exhibited increased indices of anxiety and lidocaine-treated rats exhibited decreased closed-arm entries. The minute-by-minute analysis showed a faster decrease in anxiety-related behaviors during the test session by saline- than by lidocaine-treated rats and a significant decrease in closed-arm exploration by saline-treated rats, but not by lidocaine-treated ones. Lidocaine injection before the retest session produced increases in the frequency of entries, time spent and distance run in the open arms in the second session when compared with saline-treated rats. Minute-by-minute analysis showed an increase in the time spent in the open arms by lidocaine animals at the beginning of the retest session in comparison to saline animals and a significant decrease in closed-arm exploration by both groups. These results suggest that inactivation of the medial septum by lidocaine affects the expression of unconditioned and conditioned forms of anxiety in the elevated plus-maze and, in a lesser way, the acquisition and retention of spatial information.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Lamprea MR,Garcia AM,Morato Sdoi
10.1016/j.bbr.2010.02.011subject
Has Abstractpub_date
2010-06-26 00:00:00pages
67-73issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(10)00111-7journal_volume
210pub_type
杂志文章abstract::We have learned to detect, predict and behaviorally respond to important changes in our environment on short and longer time scales. Therefore, brains of humans and higher animals build upon a perceptual and semantic salience stored in their memories mainly generated by associative reinforcement learning. Functionally...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/j.bbr.2015.11.016
更新日期:2016-02-15 00:00:00
abstract::We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-isc...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(00)00287-4
更新日期:2001-01-08 00:00:00
abstract::The object recognition task is a commonly used test for the assessment of memory functions in rodents. In this paper different aspects concerning the analysis of object recognition data are discussed. Using a set of experimental studies and fictive data sets, it was shown that the absolute discrimination measure (d1) ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2012.03.024
更新日期:2012-07-01 00:00:00
abstract::The present study assessed the spatial abilities of male and female human participants using different versions of the non-navigational Corsi block-tapping test (CBT) and a search task. Males performed significantly better than females on the standard manual version of the CBT; however, the standard CBT does not allow...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2013.09.027
更新日期:2013-11-15 00:00:00
abstract::β-Amyloid (Aβ) elevation, tau hyperphosphorylation, and neuroinflammation are major hallmarks of Alzheimer's disease (AD). Glycogen synthase kinase-3β (GSK-3β) is a key protein kinase implicated in the pathogenesis of AD. Blockade of GSK-3β is an attractive therapeutic strategy for AD. Isoorientin, a 6-C-glycosylflavo...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112968
更新日期:2021-02-01 00:00:00
abstract::Spatial discrimination learning in aged rats serves as an animal model of cognitive aging. We assessed the replicability of spatial discrimination performance in the standard Morris water escape task. To this end the learning curves and the performance in a probe trial of 24-month-old outbred Wistar (HsdWin:Wu) contro...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(97)02284-5
更新日期:1997-09-01 00:00:00
abstract::Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates. The current study investigated whether adolescent cocaine exposure activated neurons in areas of hamster forebrain implicated in aggressive behavior by examining the expre...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2004.11.027
更新日期:2005-04-30 00:00:00
abstract::The rabbit classical nictitating membrane/eyeblink conditioning preparation has proven highly valuable for delineating neural structures and systems involved in associative learning. Research conducted over the last 20 years has revealed that the essential neural circuitry for acquisition and performance of this simpl...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/s0166-4328(99)00181-3
更新日期:2000-06-01 00:00:00
abstract::The effects on latent inhibition (LI; a delay in conditioning when a CS has been pre-exposed without consequences) of repeated restraint stress and the anxiolytic drug diazepam were examined in C57BL/6 mice to know whether previous aversive events or anxiolysis are factors determining the expression of LI. The LI mode...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2007.06.002
更新日期:2007-11-02 00:00:00
abstract::Acuity was measured in 48 prematurely born infants using the preferential looking technique. These quantitative results show that acuity development in these infants is related to conceptional rather than postnatal age, in agreement with the qualitative findings of previous studies. Severe intraventricular haemorrhage...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90149-3
更新日期:1983-10-01 00:00:00
abstract::In the olfactory epithelium, olfactory sensitive neurons and their axons are surrounded by glia-like cells called sustentacular cells, which maintain both the structural and ionic integrity of the olfactory mucosa. We have previously found that endothelin-1 (ET-1) can uncouple sustentacular cell gap junctions in vitro...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2018.12.048
更新日期:2019-04-19 00:00:00
abstract::Thinking creatively requires the ability to consciously augment creative insight through processes such as analogical reasoning and relational cognition. Prior work has examined augmented states of creativity using a modified verb generation task which requires brief engagement in attempts to think creatively during M...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.112082
更新日期:2019-11-05 00:00:00
abstract::The pyramidal tract of the rat consists of at least two components. A majority of the fibers cross in the lower medulla and descend through the spinal cord in the ventral portion of the dorsal funiculus. The remaining 5% of the corticospinal projection does not cross and descends in the ipsilateral ventral funiculus i...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00051-7
更新日期:2002-08-21 00:00:00
abstract::Tissue plasminogen activator (tPA) is known to play physiologically and pathologically crucial roles in the central nervous system. However, it is still obscure whether it affects social behavior. We investigated social behavior and neuronal activation after social stimulation in tPA knockout (KO) mice. In a resident-...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.11.022
更新日期:2015-03-15 00:00:00
abstract::When exposed to extreme cold or injected with the alpha(2)-adrenoceptor agonist, clonidine, infant rats emit ultrasonic vocalizations (USVs). Based upon the cardiovascular changes that accompany these two manipulations, especially decreased venous return, it was hypothesized that USVs are the acoustic by-product of th...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(01)00369-2
更新日期:2002-04-01 00:00:00
abstract::Microdialysis was used to study the effects of exposure to a male hamster on extracellular concentrations of dopamine, dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindole acetic acid (5-HIAA) in the ventral striatum of ovariectomized female Syrian hamsters pretreated with either estradiol ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(93)90111-3
更新日期:1993-06-30 00:00:00
abstract::Probabilistic learning is a fundamental cognitive ability that extracts and represents regularities of our environment enabling predictive processing during perception and acquisition of perceptual, motor, cognitive, and social skills. Previous studies show competition between neural networks related to executive func...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2020.112733
更新日期:2020-09-01 00:00:00
abstract::Rats in which all neocortex had been surgically removed produced similar patterns of performance to those previously established for rabbits with total neocortical ablations in a bar-pressing task for food reward. The animals deprived of neocortex developed inefficient patterns of food-tray related behaviours and a li...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(80)90034-0
更新日期:1980-06-01 00:00:00
abstract::Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2019.02.041
更新日期:2019-05-17 00:00:00
abstract::It is yet unclear if ethanol-induced motor stimulation in the open field (OF) merely reflects psychomotor stimulating effects of the drug or if this stimulation is driven or modulated by ethanol's antianxiety properties. In the present study, adolescent rats were administered with different ethanol doses or remained u...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2014.02.032
更新日期:2014-05-15 00:00:00
abstract::Rearing rats in isolation produces behavioural and neurochemical alterations similar to those observed in schizophrenia. Cannabinoids have also been implicated in inducing psychotic symptoms. In this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid CB(1) recept...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2005.07.009
更新日期:2006-01-06 00:00:00
abstract::The peripheral hormone epinephrine (EPI) is known to modulate memory for arousing experiences. The mnemonic effects of EPI are attributed almost exclusively to actions on amygdala noradrenergic (NE) systems. EPI also increases neuronal activity in the locus coeruleus (LC), the primary source of NE to other limbic stru...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2003.11.005
更新日期:2004-08-12 00:00:00
abstract::The chronic unpredictable mild stress (CMS) is a paradigm developed in animals to model the relatively minor and unanticipated irritants that lead to a state of anhedonia in some individuals. However, the effectiveness of CMS is sometimes difficult to establish, for which unique strain sensitivities has been attribute...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/s0166-4328(02)00222-x
更新日期:2002-11-15 00:00:00
abstract::Administration of Triazolam (Tz)--a short acting benzodiazepine (BZ)--induces permanent phase-shifts in locomotor activity of golden hamsters (Mesocricetus auratus). However, the target area(s) as well as the mechanism involved in the Tz-induced changes are not known. Previous results indicated that raphe nuclei (RN) ...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(94)90034-5
更新日期:1994-05-30 00:00:00
abstract::Poor vascular health, atherosclerosis, or cardiac procedures in the elderly result in clinically silent microvascular infarcts that increase susceptibility to larger ischemic episodes and can precipitate changes in mood and cognition. Although the mechanisms that underlie ischemia-induced behavioral changes have not b...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2016.01.057
更新日期:2016-04-15 00:00:00
abstract::The effects of neonatal testicular hormones on preference behaviour for an oestrous female rat were investigated. A residential maze was used in which the position of the animals was registered continuously without disturbing them. Two experiments are described. In the first experiment adult male rats which had been c...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(84)90197-9
更新日期:1984-04-01 00:00:00
abstract::Injection of the GABA(A) receptor agonist muscimol into the nucleus accumbens shell (AcbSh) elicits robust feeding in satiated rats, but has no effect on water intake. The current study was designed to examine whether intra-AcbSh muscimol injections influence the intake of ethanol solutions in rats trained to drink us...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2010.08.032
更新日期:2011-01-20 00:00:00
abstract::The function(s) of sleep would probably be better understood if the metabolic processes taking place within the central nervous system (CNS) during sleep were known in greater detail. The general pattern of the energy requirements of the brain during sleep is now outlined. Brain energy metabolism dramatically decrease...
journal_title:Behavioural brain research
pub_type: 杂志文章,评审
doi:10.1016/0166-4328(95)00017-n
更新日期:1995-07-01 00:00:00
abstract::The effects of 6-hydroxydopamine-induced depletion of forebrain noradrenaline (NA) on oral intake of ethanol were studied in male Wistar rats. Prior depletion of NA produced a smaller and significantly less variable intake of a concentrated solution of ethanol than that of control rats, and this effect was not accompa...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/0166-4328(83)90168-7
更新日期:1983-04-01 00:00:00
abstract::We investigated the neurobiological bases of variation in response to predator stress (PS). Sixteen days after treatment (PS or handling), rats were grouped according to anxiety in the elevated plus maze (EPM). Acoustic startle was also measured. We examined the structure of dendritic trees of basolateral amygdala (BL...
journal_title:Behavioural brain research
pub_type: 杂志文章
doi:10.1016/j.bbr.2011.09.009
更新日期:2012-01-01 00:00:00