Abstract：
:We examined four different learning and memory tasks in rats which had been subjected to left carotid artery ligation followed by 2 h hypoxia (8% oxygen) when they were 7 days old. The examination began on the 4th week after insult and continued to 18 weeks post-insult. Compared with the control group, the hypoxic-ischemic group showed significant learning impairments in choice reaction time tasks relating to the attention process, and in plus-maze tasks and water maze tasks which examine long-term reference memory. In eight-arm radial maze tasks representing both short-term working memory and long-term reference memory, inferiority of the hypoxic-ischemic group was transient. Results of the sensorimotor test were normal in the hypoxic-ischemic group although slight flexion and twisting in the right forelimb was observed in 30% of the hypoxic-ischemic group when suspended by the tail. These abnormalities did not affect the results of learning tests. Findings of the study indicate that left-side brain damage produced by hypoxia-ischemia at 7 days of age resulted in selective and long-lasting learning and memory impairment.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Ikeda T,Mishima K,Yoshikawa T,Iwasaki K,Fujiwara M,Xia YX,Ikenoue Tdoi
10.1016/s0166-4328(00)00287-4subject
Has Abstractpub_date
2001-01-08 00:00:00pages
17-25issue
1eissn
0166-4328issn
1872-7549pii
S0166-4328(00)00287-4journal_volume
118pub_type
杂志文章abstract：:Rats readily learn to anticipate a reward signaled by an external stimulus. Anticipatory behaviors evoked by conditioned stimuli include 50 kHz ultrasonic vocalizations (USVs), a proposed behavioral correlate of positive affect and activation of midbrain dopamine pathways. Rats can also anticipate a reward, such as fo...
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journal_title：Behavioural brain research
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pub_type： 杂志文章,评审
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Behavioural brain research
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journal_title：Behavioural brain research
pub_type： 杂志文章
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