Effect of prior experience on bar-pressing in rats without neocortex.

Abstract:

:Rats in which all neocortex had been surgically removed produced similar patterns of performance to those previously established for rabbits with total neocortical ablations in a bar-pressing task for food reward. The animals deprived of neocortex developed inefficient patterns of food-tray related behaviours and a limit to their bar-pressing performance for intermittent rewards in the region of 4-10 presses per reward. The lesioned animals were also unable to form a sequential brightness discrimination on a GO-NOGO schedule using a bar-press response. Neither prior experience of other instrumental learning situations nor experience of working in the same apparatus and using the same instrumental response were sufficient to improve subsequent bar-press performance for intermittent reward in the neocortically lesioned animals. Previous success in improving such performance by pretraining procedures designed to facilitate identification of the part of the apparatus to be manipulated by the animal cannot easily be explained, therefore, on the basis of such incidental factors as increased behavioural sophistication or of increased familiarity with the apparatus and the instrumental response itself. The data are consistent with the view that the neodecorticate's difficulty in the bar-pressing situations for intermittent rewards is due to inadequate identification of cues associated with the object to be manipulated rather than to an associative learning deficit.

journal_name

Behav Brain Res

authors

Oakley DA,Russell IS

doi

10.1016/0166-4328(80)90034-0

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

267-83

issue

3

eissn

0166-4328

issn

1872-7549

pii

0166-4328(80)90034-0

journal_volume

1

pub_type

杂志文章
  • Functional aspects of the involvement of the hippocampus in behavior and memory functions.

    abstract::In order to outline the involvement of the hippocampus in behavior and memory functions the results of grafting experiments in the hippocampal formation are presented in addition to former lesion and stimulation studies. Grafts of fetal hippocampal tissue were found to induce short-term beneficial effects on learning ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/0166-4328(94)00125-y

    authors: Sprick U

    更新日期:1995-01-23 00:00:00

  • Cocaine deprivation effect: cue abstinence over weekends boosts anticipatory 50-kHz ultrasonic vocalizations in rats.

    abstract::In drug dependence studies, rats are often tested daily with short breaks (such as weekends) spent untested in their home cages. Research on alcohol models has suggested that breaks from continuous testing can transiently enhance self-administration (termed the "alcohol deprivation effect"). The present study explored...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.04.057

    authors: Maier EY,Ahrens AM,Ma ST,Schallert T,Duvauchelle CL

    更新日期:2010-12-06 00:00:00

  • Cocaine- and amphetamine-regulated transcript peptide (CART) in the central nucleus of amygdala potentiates behavioral and hormonal responses of the rat exposed to its predator.

    abstract::Since cocaine- and amphetamine-regulated transcript peptide (CART) regulates anxiety and stress in amygdala, we hypothesized that the peptide may also process negative psychological experience like fear. During acute exposure to a cat, the rat showed freezing behavior and subsequently, profound signs of anxiety in soc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2012.12.058

    authors: Upadhya MA,Kokare DM,Subhedar NK

    更新日期:2013-04-15 00:00:00

  • To the self and beyond: Arousal and functional connectivity of the temporo-parietal junction contributes to spontaneous sensations perception.

    abstract::The temporoparietal junction (TPJ), along with the anterior insula (AI) and the extrastriate body area (EBA), play a major part in embodiment and self-awareness. However, these connections also appear to be frequently engaged in arousal and attentional processing of external events. Considering that these networks may...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2020.112880

    authors: Salgues S,Plancher G,Jacquot L,Naveteur J,Fanuel L,Gálvez-García G,Michael GA

    更新日期:2021-01-01 00:00:00

  • Speeding up visual discrimination learning in cats by differential exposure of positive and negative stimuli.

    abstract::We have developed an adaptive training method which considerably reduces the total time required to train cats to threshold in an orientation discrimination task. During training, the animals are given greater exposure in time to the positive stimulus compared to the negative one. Therefore, this method has been coine...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(90)90153-6

    authors: de Weerd P,Vandenbussche E,Orban GA

    更新日期:1990-01-01 00:00:00

  • Pharmacokinetic and pharmacodynamic properties of stimulants: implications for the design of new treatments for ADHD.

    abstract::In the USA, the stimulant drug methylphenidate (MPH) is used to treat a large number (2 million or more per year) of children with Attention Deficit Hyperactivity Disorder (ADHD). Although the US FDA approved MPH in the 1960s, the pharmacokinetic (PK) properties of serum concentrations of MPH in children with ADHD wer...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/s0166-4328(01)00433-8

    authors: Swanson JM,Volkow ND

    更新日期:2002-03-10 00:00:00

  • Simultaneous assessment of autonomic function and anxiety-related behavior in BALB/c and C57BL/6 mice.

    abstract::In humans, anxiety is accompanied by changes in autonomic nervous system function, including increased heart rate, body temperature, and blood pressure, and decreased heart rate variability. In rodents, anxiety is inferred by examining anxiety-related behavioral responses such as avoidance and freezing, and more infre...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2006.11.025

    authors: Depino AM,Gross C

    更新日期:2007-02-27 00:00:00

  • 5-HT2A/C receptors do not mediate the attenuation of compulsive checking by mCPP in the quinpirole sensitization rat model of obsessive-compulsive disorder (OCD).

    abstract::There is emerging evidence for a dopamine (DA)-serotonin (5-HT) interaction underlying obsessive-compulsive disorder (OCD). In the quinpirole sensitization rat model of OCD, compulsive checking is induced by chronic treatment with the DA agonist quinpirole, and is attenuated by the 5-HT agonist drug mCPP. However, mCP...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.11.017

    authors: Tucci MC,Dvorkin-Gheva A,Johnson E,Wong M,Szechtman H

    更新日期:2015-02-15 00:00:00

  • Behavioural and cellular effects of exogenous amyloid-β peptides in rodents.

    abstract::A better understanding of Alzheimer's disease (AD) and the development of disease modifying therapies are some of the biggest challenges of the 21st century. One of the core features of AD are amyloid plaques composed of amyloid-beta (Aβ) peptides. The first hypothesis proposed that cognitive deficits are linked to pl...

    journal_title:Behavioural brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.bbr.2011.08.024

    authors: Chambon C,Wegener N,Gravius A,Danysz W

    更新日期:2011-12-01 00:00:00

  • Behavioral performance altering effects of MK-801 in zebrafish (Danio rerio).

    abstract::MK-801, a non-competitive NMDA-R antagonist, has been utilized in the analysis of mammalian learning and memory. The zebrafish is a novel vertebrate study species that has been proposed for the analysis of the mechanisms of learning and memory. Although learning paradigms have been developed for this species, psychoph...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2011.02.019

    authors: Sison M,Gerlai R

    更新日期:2011-07-07 00:00:00

  • Acute deep brain stimulation in the thalamic reticular nucleus protects against acute stress and modulates initial events of adult hippocampal neurogenesis.

    abstract::Deep brain stimulation (DBS) is used as an alternative therapeutic procedure for pharmacoresistant psychiatric disorders. Recently the thalamic reticular nucleus (TRN) gained attention due to the description of a novel pathway from the amygdala to this nucleus suggesting that may be differentially disrupted in mood di...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2016.07.022

    authors: Magdaleno-Madrigal VM,Pantoja-Jiménez CR,Bazaldúa A,Fernández-Mas R,Almazán-Alvarado S,Bolaños-Alejos F,Ortíz-López L,Ramírez-Rodriguez GB

    更新日期:2016-11-01 00:00:00

  • Dissociating effects of acute photic stress on spatial, episodic-like and working memory in the rat.

    abstract::Adaptively responding to acute stress has been of great importance for human and animal survival. However, for our species, stress-related disorders are putting an ever-increasing burden on healthcare systems. It is thus crucial to understand the basic processes and cognitive changes associated with acute stress. Here...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.07.007

    authors: Passecker J,Barlow S,O'Mara SM

    更新日期:2014-10-01 00:00:00

  • Sex determines effect of physical activity on diet preference: Association of striatal opioids and gut microbiota composition.

    abstract::Previous studies suggest an interaction between the level of physical activity and diet preference. However, this relationship has not been well characterized for sex differences that may exist. The present study examined the influence of sex on diet preference in male and female Wistar rats that were housed under eit...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.07.018

    authors: Lee JR,Muckerman JE,Wright AM,Davis DJ,Childs TE,Gillespie CE,Vieira-Potter VJ,Booth FW,Ericsson AC,Will MJ

    更新日期:2017-09-15 00:00:00

  • Effects of neonatal testicular hormones on preference behaviour in the rat.

    abstract::The effects of neonatal testicular hormones on preference behaviour for an oestrous female rat were investigated. A residential maze was used in which the position of the animals was registered continuously without disturbing them. Two experiments are described. In the first experiment adult male rats which had been c...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(84)90197-9

    authors: Merkx J

    更新日期:1984-04-01 00:00:00

  • Acute and chronic alcohol administration: effects on performance of zebrafish in a latent learning task.

    abstract::Alcohol abuse is a major medical problem. Zebrafish have been proposed to model alcohol related human disorders. Alcohol impairs learning and memory. Here, we analyze the effects of alcohol on performance of zebrafish in a recently developed latent learning paradigm. We employ a 2×3×2 experimental design (chronic×acut...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2014.12.013

    authors: Luchiari AC,Salajan DC,Gerlai R

    更新日期:2015-04-01 00:00:00

  • Anterior forebrain pathway is needed for stable song expression in adult male white-crowned sparrows (Zonotrichia leucophrys).

    abstract::The anterior forebrain pathway of the avian song system is involved in juvenile song learning, but its function in adult song behavior is not known. This report uses lesions to study the role of a particular forebrain nucleus, IMAN, in the seasonal regeneration of song in adult white-crowned sparrows (Zonotrichia leuc...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(98)00011-4

    authors: Benton S,Nelson DA,Marler P,DeVoogd TJ

    更新日期:1998-11-01 00:00:00

  • A neurotoxic regimen of methamphetamine impairs novelty recognition as measured by a social odor-based task.

    abstract::Repeated administration of methamphetamine (mAMPH) to rodents in a single-day "binge" regimen damages forebrain monoaminergic nerve terminals and produces subsequent cognitive deficits. Here we investigate performance on a social odor-based task, demonstrating enduring mAMPH-induced deficits in recognition memory. Thr...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.08.022

    authors: O'Dell SJ,Feinberg LM,Marshall JF

    更新日期:2011-01-01 00:00:00

  • Paw preference in dogs: relations between lateralised behaviour and immunity.

    abstract::Paw use in a task consisting of the removal of a piece of adhesive paper from the snout was investigated in 80 mongrel and pure-bred domestic dogs (Canis familiaris). Population lateralisation was observed, but in opposite directions in the two sexes (animals were not desexed): males preferentially used their left paw...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.01.009

    authors: Quaranta A,Siniscalchi M,Frate A,Vallortigara G

    更新日期:2004-08-31 00:00:00

  • Involvement of serotoninergic 5-HT1A/2A, alpha-adrenergic and dopaminergic D1 receptors in St. John's wort-induced prepulse inhibition deficit: a possible role of hyperforin.

    abstract::Prepulse inhibition (PPI) of acoustic startle response is a valuable paradigm for sensorimotor gating processes. Previous research showed that acute administration of St. John's wort extract (500 mg/kg, p.o.) to rats caused significant disruption of PPI while elevating monoamines levels in some brain areas. The cause-...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2008.12.015

    authors: Tadros MG,Mohamed MR,Youssef AM,Sabry GM,Sabry NA,Khalifa AE

    更新日期:2009-05-16 00:00:00

  • The effect of Delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats.

    abstract::Rearing rats in isolation produces behavioural and neurochemical alterations similar to those observed in schizophrenia. Cannabinoids have also been implicated in inducing psychotic symptoms. In this study, we investigate the effect of the major psychoactive constituent of cannabis and partial cannabinoid CB(1) recept...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2005.07.009

    authors: Malone DT,Taylor DA

    更新日期:2006-01-06 00:00:00

  • Spatial learning impairment in aged rats: comparing between aged basal forebrain lesioned and normal aged rats.

    abstract::Normal aged rats (26 months) displayed significant impairments in learning the Morris water maze task as compared with young adult rats (3 months). The learning deficits of aged basal forebrain (BF)-lesioned rats (26 months; ethylcholine aziridinium ion was injected into the bilateral basal forebrain at 3 months age) ...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(94)00182-f

    authors: Nakamura S,Ohno T

    更新日期:1995-09-01 00:00:00

  • Unit activity in the medial septum during differential appetitive conditioning.

    abstract::Unit activity in the medial septal area of the rat was studied during pavlovian appetitive differential conditioning. The firing pattern of cells in the medial septum is that of suppression to presentation of the conditioned excitor and no significant increase to the presentation of the conditioned inhibitor. This pat...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(89)80017-8

    authors: Yadin E

    更新日期:1989-05-01 00:00:00

  • Systemic administration of MK-801, a non-competitive NMDA-receptor antagonist, elicits a behavioural deficit of rats in the Active Allothetic Place Avoidance (AAPA) task irrespectively of their intact spatial pretraining.

    abstract::Spatial orientation is considered to be an animal model of human cognitive functions. Efficient navigation is believed to require a brain representation of the environment. The role of NMDA-receptor-dependent neurotransmission in encoding spatial representations has been intensively studied; however, its involvement i...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.10.013

    authors: Stuchlík A,Vales K

    更新日期:2005-04-15 00:00:00

  • Blockade of opioid receptors in anterior cingulate cortex disrupts ethanol-seeking behavior in mice.

    abstract::The anterior cingulate cortex (ACC) and opioid receptors have been suggested to play a role in attributing incentive motivational properties to drug-related cues. We examined whether blockade of ACC opioid receptors would reduce cue-induced ethanol-seeking behavior in mice. We show that intra-ACC opioid receptor block...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2010.12.033

    authors: Gremel CM,Young EA,Cunningham CL

    更新日期:2011-06-01 00:00:00

  • Interocular transfer of habituation in pigeons: mediation by tectal and/or posterior commissures.

    abstract::Interocular transfer of the habituation to diffuse photic stimuli was demonstrated to be almost complete in pigeons. Birds submitted to visual Wulst ablation or supraoptic commissure lesion performed in much the same way. In contrast, when the tectal and posterior commissures were lesioned, pigeons failed to show inte...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/0166-4328(87)90054-4

    authors: Hamassaki DE,Britto LR

    更新日期:1987-02-01 00:00:00

  • Treatment with reduced nicotinamide adenine dinucleotide (NADH) improves water maze performance in old Wistar rats.

    abstract::Age-associated cognitive impairment and related neurodegenerative disorders are an increasing major public health problem. Nicotinamide adenine dinucleotide (NADH), a co-substrate for energy transfer in the mitochondrial respiratory chain, is speculated to induce positive effects in some of these diseases. Studies sho...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2004.02.001

    authors: Rex A,Spychalla M,Fink H

    更新日期:2004-09-23 00:00:00

  • Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task.

    abstract::For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navi...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/s0166-4328(01)00399-0

    authors: Astur RS,Taylor LB,Mamelak AN,Philpott L,Sutherland RJ

    更新日期:2002-04-15 00:00:00

  • Generalized seizures evoked by nucleus accumbens stimulation induced an opiate-mediated suppression of psychosis relevant behaviors.

    abstract::We have previously demonstrated that kindling of the nucleus accumbens (NAc) induced psychosis relevant behaviors only after one, but not after five, stage-5 seizures, suggesting that five stage-5 NAc-evoked seizures antagonized psychosis relevant behaviors in rats. We hypothesized that brain opioid receptors are resp...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2018.09.007

    authors: Leung LS,Ma J

    更新日期:2019-01-01 00:00:00

  • Manipulation of visual information affects control strategy during a visuomotor tracking task.

    abstract::Proper understanding of motor control requires insight into the extent and manner in which task performance and control strategy are influenced by various aspects of visual information. We therefore systematically manipulated the visual presentation (i.e., scaling factor and optical flow density) of a visuomotor track...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2017.04.056

    authors: Bank PJM,Dobbe LRM,Meskers CGM,de Groot JH,de Vlugt E

    更新日期:2017-06-30 00:00:00

  • Testing the role of reward and punishment sensitivity in avoidance behavior: a computational modeling approach.

    abstract::Exaggerated avoidance behavior is a predominant symptom in all anxiety disorders and its degree often parallels the development and persistence of these conditions. Both human and non-human animal studies suggest that individual differences as well as various contextual cues may impact avoidance behavior. Specifically...

    journal_title:Behavioural brain research

    pub_type: 杂志文章

    doi:10.1016/j.bbr.2015.01.033

    authors: Sheynin J,Moustafa AA,Beck KD,Servatius RJ,Myers CE

    更新日期:2015-04-15 00:00:00