Abstract:
:For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navigate to a hidden escape platform in a pool, patients with HPC resections display severe impairments in spatial navigation relative to age-matched controls and age-matched patients who have had extra-HPC resections. This effect occurred for every patient tested and was evident regardless of side of surgery. Hence, it is apparent across species and irrespective of which hemisphere is damaged that the human HPC is critical for spatial/relational memory.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Astur RS,Taylor LB,Mamelak AN,Philpott L,Sutherland RJdoi
10.1016/s0166-4328(01)00399-0subject
Has Abstractpub_date
2002-04-15 00:00:00pages
77-84issue
1eissn
0166-4328issn
1872-7549pii
S0166432801003990journal_volume
132pub_type
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