Abstract：
:We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
journal_name
Behav Brain Resjournal_title
Behavioural brain researchauthors
Tabansky I,Quinkert AW,Rahman N,Muller SZ,Lofgren J,Rudling J,Goodman A,Wang Y,Pfaff DWdoi
10.1016/j.bbr.2014.07.026subject
Has Abstractpub_date
2014-10-15 00:00:00pages
123-32eissn
0166-4328issn
1872-7549pii
S0166-4328(14)00475-6journal_volume
273pub_type
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